Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259

Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI… More >

Abhijit Sinha Roy^*, Lloyd H. Back^†, Rupak K. Banerjee^‡

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 229-246, 2008, DOI:10.3970/mcb.2008.005.229

Abstract The in vivo and ex vivo compliance of arteries are expected to be closely related and estimated. Fluid-structure interaction analysis can assess the agreement between the two compliances. To evaluate this hypothesis, a pulsatile fluid-structure interaction analysis of blood flow in femoral artery of a dog was conducted using: (1) measured in vivo mean pressure (72.5 mmHg), mean pressure drop (0.59 mmHg), mean velocity (15.1 cm/sec); and (2) ex vivo measurements of non -- linear elastic properties of femoral artery. Additional analyses were conducted for physiological pressures (104.1 and 140.7 mmHg) and blood flow using a characteristic linear pressure More >

Jyoti Ranjan Majhi, Ranjan Ganguli¹

CMES-Computer Modeling in Engineering & Sciences, Vol.27, No.1&2, pp. 25-36, 2008, DOI:10.3970/cmes.2008.027.025

Abstract The flapping equation for a rotating rigid helicopter blade is typically derived by considering 1) small flap angle, 2) small induced angle of attack and 3) linear aerodynamics. However, the use of nonlinear aerodynamics can make the assumptions of small angles suspect. A general equation describing helicopter blade flap dynamics for large flap angle and large induced inflow angle of attack is derived in this paper with nonlinear aerodynamics . Numerical simulations are performed by solving the nonlinear flapping ordinary differential equation for steady state conditions and the validity of the small angle approximations are More >

Tomonori Yamada¹, Shinobu Yoshimura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.24, No.1, pp. 51-60, 2008, DOI:10.3970/cmes.2008.024.051

Abstract Flight dynamics of flapping insects is still an open area of research, though it is well known that they can provide superior flight abilities such as hovering motion. The numerical analysis of flapping wing requires fluid-structure interaction (FSI) analysis to evaluate the effect of deformable wing on flight ability. Such FSI analysis is quite challenging because not only the tight coupling approach to predict flight ability accurately, but also the robust mesh control to trace the large motion of the wing with elastic deformation are required. A new iterative partitioned coupling algorithm for the FSI More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries More >

Chun Yang¹, Dalin Tang², Chun Yuan³, Thomas S. Hatsukami⁴, Jie Zheng⁵, Pamela K. Woodard⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.19, No.3, pp. 233-246, 2007, DOI:10.3970/cmes.2007.019.233

Abstract It has been recognized that fluid-structure interactions (FSI) play an important role in cardiovascular disease initiation and development. However, in vivo MRI multi-component FSI models for human carotid atherosclerotic plaques with bifurcation and quantitative comparisons of FSI models with fluid-only or structure-only models are currently lacking in the literature. A 3D non-Newtonian multi-component FSI model based on in vivo/ex vivo MRI images for human atherosclerotic plaques was introduced to investigate flow and plaque stress/strain behaviors which may be related to plaque progression and rupture. Both artery wall and plaque components were assumed to be hyperelastic,… More >

D. Soares Jr.¹, W.J. Mansur^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.2, pp. 153-164, 2005, DOI:10.3970/cmes.2005.008.153

Abstract A coupling procedure is described to perform time-domain numerical analyses of dynamic fluid-structure interaction. The fluid sub-domains, where acoustic waves propagate, are modeled by the Boundary Element Method (BEM), which is quite suitable to deal with linear homogeneous unbounded domain problems. The Finite Element Method (FEM), on the other hand, models the structure sub-domains, adopting a time marching scheme based on implicit Green's functions. The BEM/FEM coupling algorithm here developed is very efficient, eliminating the drawbacks of standard and iterative coupling procedures. Stability and accuracy features are improved by the adoption of different time steps More >

S. Rugonyi, K. J. Bathe¹

CMES-Computer Modeling in Engineering & Sciences, Vol.2, No.2, pp. 195-212, 2001, DOI:10.3970/cmes.2001.002.195

Abstract The solution of fluid flows, modeled using the Navier-Stokes or Euler equations, fully coupled with structures/solids is considered. Simultaneous and partitioned solution procedures, used in the solution of the coupled equations, are briefly discussed, and advantages and disadvantages of their use are mentioned. In addition, a simplified stability analysis of the interface equations is presented, and unconditional stability for certain choices of time integration schemes is shown. Furthermore, the long-term dynamic stability of fluid-structure interaction systems is assessed by the use of Lyapunov characteristic exponents, which allow differentiating between a chaotic and a regular system More >