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  • Open Access

    ARTICLE

    Improvement in perioperative care in pediatric cardiac surgery by shifting the primary focus of treatment from cardiac output to perfusion pressure: Are beta stimulants still needed?

    Amir-Reza Hosseinpour1, Mathieu van Steenberghe1, Marc-André Bernath2, Stefano Di Bernardo3, Marie-Hélène Pérez4, David Longchamp4, Mirko Dolci2, Yann Boegli2, Nicole Sekarski3, Javier Orrit1, Michel Hurni1, René Prêtre1, Jacques Cotting4

    Congenital Heart Disease, Vol.12, No.5, pp. 570-577, 2017, DOI:10.1111/chd.12485

    Abstract Objective: An important aspect of perioperative care in pediatric cardiac surgery is maintenance of optimal hemodynamic status using vasoactive/inotropic agents. Conventionally, this has focused on maintenance of cardiac output rather than perfusion pressure. However, this approach has been abandoned in our center in favor of one focusing primarily on perfusion pressure, which is presented here and compared to the conventional approach.
    Design: A retrospective study.
    Setting: Regional center for congenital heart disease. University Hospital of Lausanne, Switzerland.
    Patients: All patients with Aristotle risk score ≥8 that underwent surgery from 1996 to 2012 were included. Patients operated between 1996 and… More >

  • Open Access

    ARTICLE

    Numerical Simulation of Droplet Breakup, Splitting and Sorting in a Microfluidic Device

    Chekifi. T1,2, Dennai. B1, Khelfaoui. R1

    FDMP-Fluid Dynamics & Materials Processing, Vol.11, No.3, pp. 205-220, 2015, DOI:10.3970/fdmp.2015.011.205

    Abstract Droplet generation, splitting and sorting are investigated numerically in the framework of a VOF technique for interface tracking and a finite-volume numerical method using the commercial code FLUENT. Droplets of water-in-oil are produced by a flow focusing technique relying on the use of a microchannell equipped with an obstacle to split the droplets. The influence of several parameters potentially affecting this process is investigated parametrically towards the end of identifying "optimal" conditions for droplet breakup. Such parameters include surface tension, the capillary number and the main channel width. We show that the capillary number plays More >

  • Open Access

    ARTICLE

    Erectile dysfunction in primary care: a focus on cardiometabolic risk evaluation and stratification for future cardiovascular events

    Martin Miner1, Matt T. Rosenberg2, Jack Barkin3

    Canadian Journal of Urology, Vol.21, Suppl.3, pp. 25-38, 2014

    Abstract An association between erectile dysfunction (ED) and cardiovascular disease has long been recognized, and studies suggest that ED is an independent marker of cardiovascular disease risk and even further, a marker for the burden of both obstructive and non-obstructive coronary artery disease. Therefore, the primary care physician (PCP) must assess the presence or absence of ED in every man > 39 years of age, especially if that man is asymptomatic of signs and symptoms of coronary artery disease. Assessment and management of ED may help identify and reduce the risk of future cardiovascular events, particularly… More >

  • Open Access

    HOW I DO IT

    High intensity focused ultrasound (HIFU)

    Jack Barkin

    Canadian Journal of Urology, Vol.18, No.2, pp. 5634-5643, 2011

    Abstract Introduction: Curative treatments for localized prostate cancer, from least invasive to most invasive, include brachytherapy, cryosurgery, three-dimensional conformal radiation therapy, external beam radiation therapy, and radical prostatectomy. A patient with localized, low risk or intermediate risk prostate cancer who is diagnosed at an early age and receives one of these treatments has only an approximately 50% chance of maintaining an undetectable prostate-specific antigen (PSA) level, good spontaneous erections, and total continence by 5 years after treatment.
    Objective: This article discusses transrectal high intensity focused ultrasound (HIFU) treatment of localized prostate cancer using the Sonablate 500 (Focus Surgery,… More >

  • Open Access

    MINIMALLY INVASIVE AND ROBOTIC SURGERY

    Results of high intensity focused ultrasound treatment of prostate cancer: early Canadian experience at a single center

    Dean S. Elterman1,2, Jack Barkin1,3, Sidney B. Radomski1, Neil E. Fleshner1, Brian Liu1, Kira Bensimon1, Samantha Arora1, Michael Robinette1, Antonio Finelli1

    Canadian Journal of Urology, Vol.18, No.6, pp. 6037-6042, 2011

    Abstract Introduction: High-intensity focused ultrasound (HIFU) is a non-invasive technique that uses focused ultrasound waves to ablate tissue. This retrospective study evaluates the early HIFU experience at a single Canadian center.
    Materials and methods: Ninety-five patients were treated between March 2006 and December 2007 using the Sonablate 500 device (Focus Surgery, Indianapolis, IN, USA). Follow-up was conducted at 3-month intervals and included serial prostate-specific antigen (PSA) measurements, assessment of erectile function using the International Index of Erectile Function (IIEF), and evaluation of continence rates using the Expanded Prostate Cancer Index Composite (EPIC) questionnaire. Early and late complications were… More >

  • Open Access

    ABSTRACT

    Superfast 3-D Shape Measurement with Binary Defocusing Techniques

    Song Zhang, Yajun Wang, Laura Ekstrand, Ying Xu, Yuanzheng Gong

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.18, No.2, pp. 39-40, 2011, DOI:10.3970/icces.2011.018.039

    Abstract High-speed, high-resolution 3-D shape measurement has become increasingly important, with broad applications including medicine, homeland security, and entertainment. Techniques such as structured light, stereovision, and LIDAR have led the way in this field. In recent years, we have made some progress, developing an unprecedented 60 Hz system utilizing a digital fringe projection and phase-shifting method and simultaneously achieving 40 Hz 3-D shape acquisition, reconstruction, and display. However, a conventional digital fringe projection system requires the computer to generate sinusoidal fringe patterns to be sent to the projector. Because 8 bits are usually needed to represent… More >

  • Open Access

    ARTICLE

    Karyological and electrophoretic differences between Pomacea flagellata and P. patula catemacensis (Caenogastropoda: Ampullariidae)

    MARÍA ESTHER DIUPOTEX-CHONG*, NÉSTOR J. CAZZANIGA**, MANUEL URIBE-ALCOCER*

    BIOCELL, Vol.31, No.3, pp. 365-373, 2007, DOI:10.32604/biocell.2007.31.365

    Abstract The widespread Mexican apple snail Pomacea flagellata (Say 1827) and the strictly endemic "tegogolo" P. patula catemacensis (Baker 1922) (restricted to Lake Catemaco), are the only known American Ampullariidae that have haploid complements n=13. Pomacea patula catemacensis has suffered a critical reduction in abundance due to immoderate fishing for human consumption. Chromosome slides were obtained from colchicine-injected Pomacea snails collected from nine locations along the coastal zone of the Gulf of Mexico, including Lake Catemaco, for use in principal component analysis (PCA). Total proteins in foot homogenates were analyzed through isoelectric focusing (IEF) and native-PAGE electrophoresis on polyacrylamide gels.… More >

  • Open Access

    ARTICLE

    Technology review: High-Intensity Focused Ultrasound for prostate cancer

    Tom Pickles1, S. Larry Goldenberg2, Gary Steinhoff1

    Canadian Journal of Urology, Vol.12, No.2, pp. 2593-2597, 2005

    Abstract Introduction and objective: High-Intensity Focused Ultrasound (HIFU) is a technology that has moved from being used for benign prostate disease to the treatment of prostate cancer. A technology review was undertaken to guide patients and physicians as to its suitability.
    Method: An evidence-based review of published papers in the English language, with additional material from internet and other sources.
    Results and conclusions: Only case series have been published; there are no randomized studies. The quality of evidence is poor, with no reports having longer follow-up than a mean of 2 years, with median follow-ups substantially shorter. Efficacy outcomes are More >

  • Open Access

    EDITORIAL COMMENT

    Technical review: High-Intensity Focused Ultrasound for prostate cancer

    Tom Pickles, S. Larry Goldenberg, Gary Steinhoff

    Canadian Journal of Urology, Vol.12, No.3, pp. 2684-2686, 2005

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    New technologies for ablation of small renal tumors: current status

    Joseph L. Chin, Stephen E. Pautler

    Canadian Journal of Urology, Vol.9, No.4, pp. 1576-1582, 2002

    Abstract The diagnostic rate of small, "incidental" tumors which are amenable to local excision or ablation has increased significantly due to widespread use of non-invasive body imaging tests. The role of nephron-sparing tumor­ablative surgery has expanded beyond the traditional circumstances of neoplasms in solitary/functionally solitary kidneys or tumors present bilaterally. Due to technologic advances, possible therapeutic options now include open surgery, laparoscopic, percutaneous and extraciorporeal approaches, in addition to surveillance in some cases. This review will concentrate on the new energy sources available for tumor ablation rather than the different surgical approaches, with a detailed review More >

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