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    Molecular Basis of Force Development by Skeletal Muscles During and After Stretch

    Dilson E. Rassier*

    Molecular & Cellular Biomechanics, Vol.6, No.4, pp. 229-242, 2009, DOI:10.3970/mcb.2009.006.229

    Abstract When activated skeletal muscles are stretched at slow velocities, force increases in two phases: (i) a fast increase, and (ii) a slow increase. The transition between these phases is commonly associated with the mechanical detachment of cross-bridges from actin. This phenomenon is referred to asforce enhancement during stretch. After the stretch, force decreases and reaches steady-state at levels that are higher than the force produced at the corresponding length during purely isometric contractions. This phenomenon is referred to asresidual force enhancement.The mechanisms behind the increase in force during and after stretch are still a matter of debate, and have physiological… More >

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