Dalin Tang¹, Chun Yang^1,2, Tal Geva^3,4, Glenn Gaudette⁴, and Pedro J. del Nido⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.56, No.2, pp. 113-130, 2010, DOI:10.3970/cmes.2010.056.113

Abstract Right and left ventricle (RV/LV) combination models with three different patch materials (Dacron scaffold, treated pericardium, and contracting myocardium), two-layer construction, fiber orientation, and active anisotropic material properties were introduced to evaluate the effects of patch materials on RV function. A material-stiffening approach was used to model active heart contraction. Cardiac magnetic resonance (CMR) imaging was performed to acquire patient-specific ventricular geometries and cardiac motion from a patient with severe RV dilatation due to pulmonary regurgitation needing RV remodeling and pulmonary valve replacement operation. Computational models were constructed and solved to obtain RV stroke volume,… More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries More >

Jolanta Myśliwska¹, Joanna Więckiewicz¹, Łukasz Hak¹, Janusz Siebert², Jan Rogowski³, Krzysztof Szyndler³, Andrzej Myśliwski⁴

European Cytokine Network, Vol.17, No.3, pp. 181-188, 2006, DOI:10.1684/ecn.2006.0035

Abstract IL6 gene promoter polymorphisms may influence the outcome of cardiovascular diseases. The aim of our study was to find out whether the –174G>C polymorphism, as well as the IL6 secretory profile, may be linked to the number of severely (≥ 75%) occluded coronary arteries in patients with advanced coronary heart disease (CHD). Three hundred and twenty patients awaiting elective coronary artery bypass grafting were enrolled into the study. Blood was taken the day before surgery. The PCR-RFLP method was used for IL6 gene polymorphism analysis. Spontaneous IL6 release was measured by bioassay in supernatants of… More >