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  • Open Access


    A double-edged sword: The HBV-induced non-coding RNAs alterations in hepatocellular carcinoma


    BIOCELL, Vol.47, No.1, pp. 27-32, 2023, DOI:10.32604/biocell.2022.023568

    Abstract Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression, oncogenesis, and many other pathologies. Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), and some studies have shown that the expression of non-coding RNAs has an assignable effect on the development of HBV-induced HCC. In this context, the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention. This review covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA expression, cataloging the recent reports about… More >

  • Open Access


    Intelligent Medical Diagnostic System for Hepatitis B

    Dalwinder Singh1, Deepak Prashar1, Jimmy Singla1, Arfat Ahmad Khan2, Mohammed Al-Sarem3,4,*, Neesrin Ali Kurdi3

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6047-6068, 2022, DOI:10.32604/cmc.2022.031255

    Abstract The hepatitis B virus is the most deadly virus, which significantly affects the human liver. The termination of the hepatitis B virus is mandatory and can be done by taking precautions as well as a suitable cure in its introductory stage; otherwise, it will become a severe problem and make a human liver suffer from the most dangerous diseases, such as liver cancer. In this paper, two medical diagnostic systems are developed for the diagnosis of this life-threatening virus. The methodologies used to develop these models are fuzzy logic and the neuro-fuzzy technique. The diverse parameters that assist in the… More >

  • Open Access


    The Biological Function of Hepatitis B Virus X Protein in Hepatocellular Carcinoma

    Qiaodong Xu1, Songgang Gu1, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan

    Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963

    Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis and lead to… More >

  • Open Access


    MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Downregulation of ErbB3

    Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang

    Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623

    Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR- 125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells. The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the… More >

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