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  • Open Access


    HBx Downregulates miR-422a Expression via Activation of FOXG1/Q1/E1 in HepG2 Cells

    Xiaofan Deng1,2, Yamei Yang2,3, Xianfeng Gan2,3, Gang Wu2,3,*

    Oncologie, Vol.23, No.2, pp. 251-258, 2021, DOI:10.32604/Oncologie.2021.016900

    Abstract microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid tumors including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) downregulated expression of miR-422a in HCC cell line HepG2 in vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate miR-422a expression, and this prompted us to determine whether HBx suppresses miR-422a expression via activation of FOXG1/Q1/E1. The relationship between FOXG1/Q1/E1 and miR-422a in HepG2 cells stably expressing HBx was assessed with qRT-PCR. The correlation between HBx and FOXG1/Q1/E1 was determined with qRT-PCR and western blot in… More >

  • Open Access


    Fundamentals of Digestive Cancers Immunology, Especially Gastric and Hepatocellular Carcinomas
    Fondamentaux de l’immunologie des Cancers Digestifs (Gastriques et Hépatocellulaires)

    Pierre-Guillaume Poureau1,2,*, Jean-Philippe Metges2

    Oncologie, Vol.23, No.1, pp. 47-59, 2021, DOI:10.32604/Oncologie.2021.15525

    Abstract Immunotherapy for digestive cancers is booming and for the first time an immune checkpoint inhibitor has been granted marketing authorization for the treatment of digestive cancer. In order to better understand the mecanism of action of these treatments, their adverse events and the escape mecansim, it is necessary to know the fundamentals of cancer immunology. The innate and adaptive immune system allows the elimination of cancer cells by direct non-specific cytotoxicity (Natural Killer cells), by the development of an adaptive cell-mediated response (dendritic cells becoming antigen presenting cells, allowing the differentiation of lymphocytes naive in CD4 and CD8 T lymphocytes)… More >

  • Open Access


    Diagnostic Performance of Serum miR-586 and miR-493 in Patients with Osteosarcoma

    Hao Dang*

    Oncologie, Vol.22, No.1, pp. 35-42, 2020, DOI:10.32604/oncologie.2020.012485

    Abstract This study aimed to explore the expression and diagnostic performance of miR-586 and miR-493 in patients with osteosarcoma. We enrolled 63 patients with osteosarcoma treated between May 2016 and May 2019 as the experimental group and 55 healthy volunteers who underwent physical examination during the same period as the control group. We detected miR-586 and miR-493 expression in serum, normal bone tissue, and tumor samples. We also evaluated the relationship between clinical indicators and the miR-586 and miR-493 expression levels. The correlation between the serum and osteosarcoma tissue expression of miR-586 and miR-493 was examined by Pearson analysis. Furthermore, the… More >

  • Open Access


    Sinomenium Inhibits the Viability of Hepatoma Carcinoma Cells through Activating IFNA2

    Jingjing He1,2, Lingyi Zhang2, Dan Guo3, Xingwen Han4, Hui Zhang5, Liang Wang2, Youcheng Zhang1,*

    Oncologie, Vol.22, No.1, pp. 1-12, 2020, DOI:10.32604/oncologie.2020.012436

    Abstract Hepatocellular carcinoma (HCC) ranks the sixth place of most common cancers. Meanwhile, it is the tertiary mortality cause of cancer. There is no effective therapeutic method to prevent and treat the liver cancer. Sinomenine is a kind of Chinese traditional medicine herbal, it is reported that it can inhibit the viability of several cancer cells. The study is to explore whether sinomenine is also able to inhibit the cell viability of HCC and its potential mechanism. The IC50 of sinomenine in BEL-7402 cells was 5.351 mmol/L, and the IC50 of sinomenine in SMMC-7721 cells was 6.204 mmol/L. The gene expression… More >

  • Open Access


    Matrix Stiffness Promotes Hepatoma Cell Glycolysis and Migration Through YAP-Mediated Mechanotransduction

    Qiuping Liu1, Guanbin Song1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

    Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6, 25, 54 kPa were produced… More >

  • Open Access


    Glypican-3 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta-analysis

    Weiyu FU1, Hongyu LU2, Li LI3, Kefeng WU3, Yanping LI3, Yi LIU3,*, Jianli HU4,*

    BIOCELL, Vol.39, No.2-3, pp. 25-32, 2015, DOI:10.32604/biocell.2015.39.025

    Abstract Objective: To assess the diagnostic accuracy of serum GPC3 versus alpha-fetoprotein (AFP) for HCC by using the method of system review.
    Methods: PubMed and EMBASE were searched from its inception to 20, April 2014 for studies that compared diagnostic accuracy of serum GPC3 with AFP for HCC. Sensitivity, specificity and other measures were pooled using random-effects models. Summary receiver operating characteristic curve analysis was used to summarize the overall test performance.
    Results: Fourteen studies were included in this meta-analysis. Summary estimates for serum GPC3 and AFP in diagnosing HCC were as follows: sensitivity, 69% (95% confidence interval (CI), 56-80%) vs.… More >

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