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  • Open Access

    ARTICLE

    Practice trends over time in the care of infants with hypoplastic left heart syndrome: A report from the National Pediatric Cardiology Quality Improvement Collaborative

    Waldemar F. Carlo1, James F. Cnota2, Robert J. Dabal3, Jeffrey B. Anderson2

    Congenital Heart Disease, Vol.12, No.3, pp. 315-321, 2017, DOI:10.1111/chd.12442

    Abstract Objective: The National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) was established in 2008 to improve outcomes of hypoplastic left heart syndrome (HLHS) during the interstage period. They evaluated changes in patient variables and practice variation between early and late eras.
    Design: Data including demographic, operative, discharge, and follow-up variables from the first 100 patients (6/2008–1/2010) representing 18 centers were compared with the most recent 100 patients (1/2014–11/2014) from these same centers.
    Results: Prenatal diagnosis increased from 69% to 82% (P = .05). There were no differences in gestational age or weight at Norwood. A composite of any preoperative… More >

  • Open Access

    ARTICLE

    Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants

    Nilgün Köksal1, Bülent Kayık2, Merih Çetinkaya1, Hilal Özkan1, Ferah Budak3, Şebnem Kılıç4, Yakup Canıtez5, Barbaros Oral3

    European Cytokine Network, Vol.23, No.2, pp. 29-35, 2012, DOI:10.1684/ecn.2012.0304

    Abstract Objective: The aim of this study was to determine the value of pro- and anti-inflammatory cytokine levels in both blood and tracheal aspirate (TA) samples that were obtained within 24 h after birth for predicting bronchopulmonary dysplasia (BPD) development in premature infants. Material and methods: Premature infants, who were born before 32 weeks of gestation, weighing less than 1,500 g, and admitted with respiratory distress between September 2009 and December 2010, were enrolled. Tracheal aspirate samples and serum were obtained from all infants on the first day of admittance for evaluation of pro- and anti-inflammatory… More >

  • Open Access

    ARTICLE

    Effect of maternal smoking on colostrum and breast milk cytokines

    İbrahim Etem Pişkin1, Hande Nur Karavar1, Mehmet Araslı2, Bahri Ermiş3

    European Cytokine Network, Vol.23, No.4, pp. 187-190, 2012, DOI:10.1684/ecn.2013.0324

    Abstract Background: Breast milk contains several immune modulator components. The transfer of numerouscytokines via mother’s milk may add to an active stimulation of the infant’s immune system. There are many factorsin breast milk that could either facilitate or inhibit cytokine activities. Smoking negatively influences the immunesystem and changes the concentrations of important cytokines. Objective: The objective of this study was to assessthe effect of smoking during pregnancy on the cytokines found in colostrum and mature human milk. Methods: Thestudy population included 25 smoker and 27 non-smoker nursing mothers who gave birth to a term healthy infantvia… More >

  • Open Access

    ARTICLE

    Extracorporeal shockwave lithotripsy in infants

    Prem A. Ramakrishnan, Mohammed Medhat, Younis H. Al-Bulushi, Priti Nair, Ahmed Al-Kindy

    Canadian Journal of Urology, Vol.14, No.5, pp. 3684-3691, 2007

    Abstract Introduction: Pediatric urolithiasis is relatively uncommon and limited information is available on the application of minimally invasive management modalities in young children. We present a single centre experience with extracorporeal shockwave lithotripsy (ESWL) for infants with upper urinary tract calculi.
    Material and methods: A total of 74 infants aged 3 months to 24 months with upper urinary tract calculi were treated with ESWL under general anesthesia using the Wolf 2500 and the 2501 Piezolith lithotriptors over a 14 and a half-year period. Patient and stone characteristics, risk factors for urolithiasis, treatment parameters, clinical outcomes and long-term follow-up… More >

  • Open Access

    ARTICLE

    Genetic polymorphisms for vascular endothelial growth factor in perinatal complications

    Ilona Bányász1, Géza Bokodi1, Barna Vásárhelyi2, András Treszl1, László Derzbach1, András Szabó1, Tivadar Tulassay1,2,3, Ádám Vannay3

    European Cytokine Network, Vol.17, No.4, pp. 266-270, 2006, DOI:10.1684/ecn.2006.0041

    Abstract Low birth weight (LBW) infants have increased susceptibility to perinatal complications. An immature and impaired vascular system may possibly participate in these complications. There is evidence that supports the notion that vascular endothelial growth factor (VEGF), which is an essential regulator of embryonic angiogenesis, plays a central role in the pathogenesis of perinatal complications. We aimed to test whether functional genetic polymorphisms of VEGF are associated with the risk of preterm birth or perinatal morbidity. We enrolled 128 LBW infants (≤ 1500 grams). VEGF T-460C, VEGF C-2578A and VEGF G+405C polymorphisms were determined by real-time… More >

  • Open Access

    RESIDENT’S CORNER

    Inguinal herniation of the bladder in an infant

    Scott Manatt1, Jeffrey B. Campbell1, Faridali Ramji2, Ann Kuhn3, Dominic Frimberger1

    Canadian Journal of Urology, Vol.13, No.2, pp. 3057-3058, 2006

    Abstract Inguinal herniation of the bladder is an uncommon finding with fewer than 200 cases reported in the literature. It is found most commonly in older, obese men with lower urinary tract symptoms. We report a case of inguinal herniation of the bladder in a premature infant. More >

  • Open Access

    ARTICLE

    Plasma interferon-γ, interleukin-10 and soluble markers of immune activation in infants with primary adenovirus (ADV) and respiratory syncytial virus (RSV) infection

    J. Alonso Fernández1, Lorena Tapia1, M. Angélica Palomino2, Carmen Larrañaga1, Mónica Peña1, Héctor Jaramillo3

    European Cytokine Network, Vol.16, No.1, pp. 35-40, 2005

    Abstract Adenovirus (ADV) and respiratory syncytial virus (RSV) are etiological agents of acute respiratory tract infection in infants. Long-term prognosis of ADV infection includes severe lung damage, bronchiectasis and hyperlucent lung, while RSV infection is associated with development of recurrent wheezing and subsequent asthma. These differences may be related to differences in the primary immune responses elicited by these viruses. In this paper, we investigated the type of cytokine responses and the magnitude of immune activation in ADV and RSV infections in infants. We examined plasma concentrations of interferon-c (IFN-c), interleukin-10 (IL-10), soluble interleukin-2 receptor (sCD25)… More >

  • Open Access

    ARTICLE

    Safety and efficacy of extracorporeal shock wave lithotripsy in infants

    Gordon A. McLorie3, Jeff Pugach3, Dov Pode2, John Denstedt4, Darius Bagli3, Shimon Meretyk2, R. John D’A Honey4, Paul A. Merguerian3, Amos Shapiro2, Antoine E. Khoury3, Ezekiel H. Landau1

    Canadian Journal of Urology, Vol.10, No.6, pp. 2051-2055, 2003

    Abstract Purpose: Extracorporeal shock wave lithotripsy (ESWL) in older children appears to have comparable results when compared to adults, no study has focused on its use in younger children. We reviewed our ESWL experience in children under age 3.5 years to evaluate its safety, and define optimal treatment parameters.
    Methods: We retrospectively reviewed consecutive medical and diagnostic imaging records from three ESWL centers, pertaining to 34 children under 3.5 years of age (36 renal units-RU). The children were from two distinct populations served exclusively by the three centers. We analyzed patient presentation, etiology, age, weight, stone size, preoperative… More >

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