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  • Open Access


    Glyphosate retention in grassland riparian areas is reduced by the invasion of exotic trees

    Giaccio GCM1, P Laterra2, VC Aparicio3, JL Costa3

    Phyton-International Journal of Experimental Botany, Vol.85, pp. 108-116, 2016, DOI:10.32604/phyton.2016.85.108

    Abstract In this study, we examined some aspects regarding the effect of willow trees (Salix fragilis L.) invasion of grassland riparian environments in the Argentinean Pampas on the runoff reduction, sedimentation and glyphosate retention in the riparian vegetation strip (RVS). To assess the influence of willows on the filtering mechanisms, we performed runoff simulation experiments in plots of 1.5 x 2.5 m, in coastal environments characterized by the presence of willows or the lack of trees. Despite the short length of the experimental plots, the retention of glyphosate in the controls, with no trees, was higher and… More >

  • Open Access


    Effects of Three-Dimensional Stiffness on the Proliferation, Stemness And Invasion of Hepatic Cancer Stem Cells

    Mengyue Wang1, Runze Zhao1, Fan Feng1, Tingting Xia1,*, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 130-130, 2019, DOI:10.32604/mcb.2019.07154

    Abstract Hepatocellular carcinoma (HCC) is the third most common cancer in the world. Previous studies have shown that hard matrix promotes the proliferation of liver tumor cells. However, the role of matrix stiffness on hepatic cancer stem cells (HCSCs) is still unclear. Three-dimensional hydrogels with different stiffness were used to mimic the normal liver tissue (4kPa) and cancerous liver tissue (26kPa) stiffness. The proliferation, stemness and invasion properties of HCSCs under 3D different stiffness were detected. METHOD: HSCSs were screened and cultured by enrichment method, and the effect of matrix stiffness on HCSCs was studied by… More >

  • Open Access


    Decreased invasion ability of hypotaurine synthesis deficient glioma cells was partially due to hypomethylation of Wnt5a promoter

    Hong TIAN1, 2, Peiyu CONG3, Ruiqun QI4, Xinghua GAO5, Xin LIU6, Hongsheng LIU7, Fengping SHAN1,*

    BIOCELL, Vol.41, No.1, pp. 27-32, 2017, DOI:10.32604/biocell.2017.41.027

    Abstract Glioma is one of the lethal central nervous system tumors. The infiltrative and invasive growth nature makes it difficult to identify the boundary between glioma and the normal tissues, resulting in inevitable recurrence after surgery operation. Gliomas do not metastasize, so to prevent the residual tumor from proliferating or invading is a key challenge. Previous report indicated that hypotaurine could facilitate glioma invasion and suppress demethylases’ activities. Using a hypotaurine synthesis deficient U251 cell line, we proved that the cells invasion ability was impaired. Gene expression profile analysis exhibited that knocking down one of… More >

  • Open Access


    Trypanosoma cruzi invasion in non-phagocytic cells: an ultrastructural study

    Juan Agustín CUETO3, Emile SANTOS BARRIAS6, Wanderley de SOUZA4, 5, Patricia Silvia ROMANO1, 2

    BIOCELL, Vol.42, No.3, pp. 105-108, 2018, DOI:10.32604/biocell.2018.07017

    Abstract Trypanosoma cruzi is the causative agent of Chagas disease. This parasite requires the intracellular niche in order to proliferate and disseminate the infection. After invasion, T. cruzi resides temporarily in an acidic vacuole which is lysed by a not well-understood mechanism. Transmission electron microscopy was used to describe the process of T. cruzi escape from the parasitophorous vacuole over the time. Using HeLa (non-professional phagocytic cells) as host cell, we observed that recently internalized parasites reside in a membrane-bounded vacuole. A few hours later, the first sign of vacuole disruption appeared as membrane discontinuities. This observation was followed More >

  • Open Access


    SPAG9 promotes prostate cancer growth and metastasis

    Chunhua YANG1,2,3, Ye TIAN1,2,3

    BIOCELL, Vol.43, No.3, pp. 207-214, 2019, DOI:10.32604/biocell.2019.07258

    Abstract Sperm-associated antigen 9 (SPAG9) expression is increased in prostate tissues of prostate cancer patients. This experimental study aimed to investigate the role of SPAG9 in bone metastasis of prostate cancer. Immunohistochemical analysis showed that SPAG9 staining was positive in 81.67% of 240 cases of prostatic carcinoma but only in 6.67% of 120 cases of benign prostate hyperplasia. Strong PAG9 staining was positively correlated with Gleason score and bone metastasis in 240 prostate cancer patients (p < 0.05), but not with the age or serum prostatespecific antigen level (p > 0.05). PC-3 cells were transfected with shRNA… More >

  • Open Access


    HMGB1 promotes the proliferation and invasion of oral squamous cell carcinoma via activating epithelial-mesenchymal transformation

    Jie REN1, Qian LIANG2

    BIOCELL, Vol.43, No.3, pp. 199-206, 2019, DOI:10.32604/biocell.2019.07128

    Abstract This study aimed to investigate the role of high mobility group box-1 (HMGB1) expression in oral squamous cell carcinoma; HMGB1 promoted the proliferation and invasion of oral squamous cell carcinoma via activating epithelial-mesenchymal transformation (EMT). In this study, RNA transfection was used to silence the expression of HMGB1 in oral squamous cell carcinoma cells. CCK-8, cell clone formation and trans-well assays were used to detect the proliferation and invasion of cells before and after HMGB1 silencing. qRT-PCR and Western blot were used to detect changes in EMT marker protein expression before and after transfection.… More >

  • Open Access


    Amentoflavone Suppresses Cell Growth and Invasion in Renal Carcinoma Cells by Activating PPARγ

    Kun Fan1,2, Xiaofu Qiu2, Yu Fu2, Kangjian Lin, Huanhui Li2, Guosheng Yang *,1,2

    Molecular & Cellular Biomechanics, Vol.14, No.1, pp. 33-45, 2017, DOI:10.3970/mcb.2017.014.035

    Abstract This study intends to investigate the role of amentoflavone(AF) in human clear-cell renal cell carcinoma (ccRCC) and to elucidate underlying molecular mechanisms. Materials and Methods: Human RCC cell lines Caki-1 and 786-O were used in this study. Cell proliferation, apoptosis, cell cycle distribution and invasion assays were conducted to analyze the effect of AF against ccRCC in vitro. Xenograft model and pulmonary metastasis animal model were established to evaluate the vivo therapeutic efficacy and against pulmonary metastasis ability of AF, respectively. Results: Our findings revealed that AF selectively suppressed tumor cell proliferation in a dose- and More >

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