Giaccio GCM¹, P Laterra², VC Aparicio³, JL Costa³

Phyton-International Journal of Experimental Botany, Vol.85, pp. 108-116, 2016, DOI:10.32604/phyton.2016.85.108

Abstract In this study, we examined some aspects regarding the effect of willow trees (Salix fragilis L.) invasion of grassland riparian environments in the Argentinean Pampas on the runoff reduction, sedimentation and glyphosate retention in the riparian vegetation strip (RVS). To assess the influence of willows on the filtering mechanisms, we performed runoff simulation experiments in plots of 1.5 x 2.5 m, in coastal environments characterized by the presence of willows or the lack of trees. Despite the short length of the experimental plots, the retention of glyphosate in the controls, with no trees, was higher and… More >

Yun Qin^*, Xicai Tang^†, Mingxing Liu^‡

Oncology Research, Vol.23, No.1-2, pp. 13-20, 2015, DOI:10.3727/096504015X14410238486766

Abstract The purpose of this study was to assess the effects of NBPF1 expression on cervical cancer cell invasion and apoptosis and to illustrate its potential mechanism. Human cervical cancer HeLa cells were transfected with the constructed siNBPF1 or pcDNA3.1-NBPF1 vectors. Effects of NBPF1 expression on cell invasion ability and cell apoptosis were analyzed using the Matrigel method and an Annexin V-FITC cell apoptosis kit, respectively. In addition, cell apoptosis-related proteins involved with the PI3K/mTOR signaling pathway were analyzed using Western blot. Remediation experiments were conducted to verify the effects of NBPF1 expression on cell invasion… More >

Fei Meng, Wei Liu

Oncology Research, Vol.23, No.1-2, pp. 7-12, 2015, DOI:10.3727/096504015X14410238486649

Abstract Cervical cancer is the second leading type of cancer in women living in less developed countries. The pathological and molecular mechanisms of cervical cancer are not comprehensively known. Though legumain has been found to be highly expressed in various types of solid tumors, its expression and biological function in cervical cancer remain unknown. In this study, we aimed to investigate legumain expression and functions in cervical cancer. We found that legumain was highly expressed in cervical cancer cells. When knocked down, legumain expression in HeLa and SiHa cells significantly reduced its migration and invasion abilities More >

Gao Liu^*, Tian Xiang^†, Quan-Feng Wu^‡, Wei-Xing Wang^*

Oncology Research, Vol.23, No.3, pp. 99-107, 2015, DOI:10.3727/096504015X14496932933575

Abstract The lncRNA H19 and its mature product miR-675 have recently been shown to be upregulated and promote the progression of gastric cancer. However, the detailed function and underlying molecular mechanism of H19/miR- 675 in the carcinogenesis of gastric cancer remains unclear. In this study, we found that H19 depended on miR- 675 to enhance the proliferation and invasion of gastric cancer AGS cells, and the expression of miR-675 was positively correlated with H19 in patients with gastric cancer. Subsequently, the tumor-suppressor runt domain transcription factor 1 (RUNX1) was confirmed to be a downstream molecule of… More >

Si Jun Park^*1, Bo Ram Lee^*1, Hyeng-Soo Kim^*, Young Rae Ji^*, Yong Hun Sung^*, Kwang ShikChoi^*, Hum Dai Park^†, Sung-Hyun Kim^*, Myoung Ok Kim^‡, Zae Young Ryoo^*

Oncology Research, Vol.23, No.3, pp. 89-98, 2015, DOI:10.3727/096504015X14496932933539

Abstract In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of More >

Shuang Wang^*, Daqi Zhao^†, Ruihua Tian^*, Hailong Shi^*, Xiangming Chen^*, Wenzhi Liu^*, Lin Wei^*

Oncology Research, Vol.23, No.4, pp. 197-203, 2015, DOI:10.3727/096504016X14537290676919

Abstract Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that More >

Donghui Zhang^*1, Genling Yang^†1, Xidong Li^‡, Cheng Xu^*, Honglei Ge^§

Oncology Research, Vol.23, No.4, pp. 171-181, 2015, DOI:10.3727/096504016X14519995067562

Abstract Cullin7 is an E3 ubiquitin ligase. The Cullin7 protein family functions as a molecular scaffold to coordinate substrate ubiquitination in Skp, Cullin, and F-box-containing complex (SCF complex). Cullin7s control normal development and primary cellular processes and are characterized by a unique genomic network organization. Less is known about the involvement of Cullin7 with hepatocellular carcinoma (HCC). In this study, we found that Cullin7 showed a high expression in HCC tumor tissues, especially in metastatic HCC tumor tissues. Also, there was a negative correlation between Cullin7 expression and long survival. Silencing of Cullin7 in liver cancer More >

Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xinguang Qiu

Oncology Research, Vol.23, No.4, pp. 165-170, 2015, DOI:10.3727/096504016X14519157902726

Abstract Accumulating evidence has reported the significant role of miRNAs in the underlying biology of tumors, including breast cancer. The purpose for this study was to investigate the potential effects of miR-544a in breast cancer migration and invasion. The human normal breast Hs578Bst cells and the human breast cancer MCF-7 and MDA-MB-231 cells were used to analyze the expression of miR-544a by RT-PCR. The effects of miR-544a on the two kinds of breast cancer cell migration and invasion were analyzed using the Matrigel and Transwell assay, respectively. miR-544a expression on the cell metastasis-related protein expression was More >

Ming Liu, Dan Wang, Ning Li

Oncology Research, Vol.23, No.5, pp. 257-266, 2015, DOI:10.3727/096504016X14562725373752

Abstract Osteosarcoma (OS) is the most common malignant primary bone tumor disease. HIF-1α was predicted to be the target gene of microRNA-20b (miR-20b). The present study was designed to illustrate the effect of miR- 20b in regulating osteosarcoma via targeting HIF-1α. In this study, we found that the expression of HIF-1α was significantly increased, while miR-20b obviously decreased in OS patients and OS cell lines compared with healthy controls. Moreover, the luciferase report confirmed the targeting reaction between miR-20b and HIF-1α. Additionally, the overexpression of miR-20b suppressed the invasion and growth of both MG63 and U2OS More >

Hongtao Ren^*, Zhongwei Wang^*, Shuqun Zhang^*, Hongbing Ma^*, Yali Wang^*, Lijun Jia^*, Yiming Li^†

Oncology Research, Vol.23, No.5, pp. 249-256, 2015, DOI:10.3727/096504016X14562725373716

Abstract Interleukin-17A (IL-17A) plays a significant role in many inflammatory diseases and cancers. The aim of this study is to investigate the effect of IL-17A on the invasiveness of colorectal cancer. In the study, we found that IL-17A could promote the migration and invasion of colorectal cancer cells. Furthermore, after being treated with IL-17A, the expression and activity of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated. Moreover, the nuclear/overall fractions and DNA-binding activity of p65 and p50 were dramatically elevated by IL-17A. Pretreatment with a nuclear factor-kB (NF-kB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was More >