Hongtao Ren^*, Zhongwei Wang^*, Shuqun Zhang^*, Hongbing Ma^*, Yali Wang^*, Lijun Jia^*, Yiming Li^†

Oncology Research, Vol.23, No.5, pp. 249-256, 2015, DOI:10.3727/096504016X14562725373716

Abstract Interleukin-17A (IL-17A) plays a significant role in many inflammatory diseases and cancers. The aim of this study is to investigate the effect of IL-17A on the invasiveness of colorectal cancer. In the study, we found that IL-17A could promote the migration and invasion of colorectal cancer cells. Furthermore, after being treated with IL-17A, the expression and activity of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated. Moreover, the nuclear/overall fractions and DNA-binding activity of p65 and p50 were dramatically elevated by IL-17A. Pretreatment with a nuclear factor-kB (NF-kB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was More >

Jianyu Zhou^*, Xiaorong Li^*, Meirong Wu^†, Changwei Lin^*, Yihang Guo^*, Buning Tian^*

Oncology Research, Vol.23, No.6, pp. 303-309, 2015, DOI:10.3727/096504016X14567549091305

Abstract Emerging evidence has identified the vital role of long noncoding RNAs (lncRNAs) in the development of colorectal cancer. In this study, we aimed to investigate the role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in colorectal cancer. We analyzed the expression of GHET1 in colorectal cancer (CRC) tissues by using ISH. We found that GHET1 expression was significantly increased in the CRC samples compared with adjacent tissues. Furthermore, the cancer tissues had higher GHET1 mRNA levels than their matched adjacent tissues. GHET1 expression was also significantly increased in the CRC cell lines compared More >

Carlos H. Martinez¹, Andrew K. Williams¹, Joseph L. Chin¹, Larry Stitt², Jonathan I. Izawa¹

Canadian Journal of Urology, Vol.20, No.2, pp. 6696-6701, 2013

Abstract Introduction: Clinical variables with more accuracy to predict biologically insignificant prostate cancer are needed. We evaluated the combination of transrectal ultrasound-guided biopsy of the prostate (TRUSBx) pathologic and radiologic findings in their ability to predict the biologic potential of each prostate cancer.
Materials and methods: A total of 1043 consecutive patients who underwent TRUSBx were reviewed. Using pathologic criteria, patients with prostate cancer (n = 529) and those treated with radical prostatectomy (RP) (n = 147) were grouped as: “insignificant” (Gleason score ≤ 6, prostate-specific antigen (PSA) density ≤ 0.15 ng/mL, tumor in ≤ 50% of any… More >

Malik Elharram¹, David Margel², Antonio Finelli², John Trachtenberg², Andrew Evans³, Theodorus H. van der Kwast³, Joan M. Sweet², Neil Fleshner²

Canadian Journal of Urology, Vol.19, No.6, pp. 6567-6572, 2012

Abstract Introduction: The clinical significance of perineural invasion (PNI) on prostate needle biopsy is controversial. The aim of this present study is to determine the role of PNI on prostate biopsy in predicting adverse findings at radical prostatectomy in a recent cohort of screen detected prostate cancer.
Materials and methods: We analyzed 470 patients diagnosed with prostate cancer from a prospectively maintained database at Princess Margaret Hospital. Out of the 470 patients diagnosed with prostate cancer, 139 underwent radical prostatectomy. Pathological specimens were examined, and perineural invasion was identified as carcinoma tracking along or around a nerve in… More >

George R. Schade, Ofer N. Gofrit, Kevin C. Zorn

Canadian Journal of Urology, Vol.15, No.2, pp. 4012-4015, 2008

Abstract A 42-year-old woman with tuberous sclerosis (TS)presented with acute right-sided flank pain. Imaging studies demonstrated numerous bilateral renal angiomyolipomas (AML), the largest located within the right upper pole, extending into the venous system to the level of the infra-hepatic inferior vena cava (IVC).Intravascular extension of AML is quite rare, however,may potentially result in fatal complications if not appropriately treated. We present a case report and a description of the surgical management, and provide a review of the literature concerning this rare finding. More >

Pierre I Karakiewicz, Jean-Baptiste Lattouf, Paul Perrotte, Luc Valiquette, François Bénard, Michael McCormack, Catherine Ménard, Thierry Lebeau, Serge Benayoun, Alvaro Ramirez, Simon Ouaknine, Fred Saad

Canadian Journal of Urology, Vol.12, No.2, pp. 2588-2592, 2005

Abstract Objective: The accuracy of 1997 Partin Tables' lymph node invasion (LNI) predictions exhibits important variability in different testing populations. We explored the LNI predictive accuracy in radical prostatectomy (RP) patients from Montreal, Canada. Moreover, we assessed the extent of change in predictive accuracy related to a modification of PSA coding from categorical to continuous.
Methods: We used pretreatment serum PSA, clinical stage, and biopsy Gleason sum from 537 men treated with RP to compare predicted and observed rates of LNI. Accuracy was quantified with receiver-operating characteristics curves.
Results: Accuracy was 0.760 in 369 evaluable patients, when categorically coded More >