Si Jun Park^*1, Bo Ram Lee^*1, Hyeng-Soo Kim^*, Young Rae Ji^*, Yong Hun Sung^*, Kwang ShikChoi^*, Hum Dai Park^†, Sung-Hyun Kim^*, Myoung Ok Kim^‡, Zae Young Ryoo^*

Oncology Research, Vol.23, No.3, pp. 89-98, 2015, DOI:10.3727/096504015X14496932933539

Abstract In the present study, we found that lung cancer cell line (H460 cells) expressing Tet1 showed higher levels of adhesion, and Tet1 inhibited H460 cell proliferation. In addition, these cells showed a significantly reduced ability of collagen degradation and Smad2/3 phosphorylation compared to controls. Furthermore, vimentin was found to be highly expressed in larger metastatic cancer area. Tet1 overexpression was reduced in the epithelial marker E-cadherin. Moreover, Tet1 repressed cancer cell metastasis in nude mice. Collectively, these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of More >

Shuang Wang^*, Daqi Zhao^†, Ruihua Tian^*, Hailong Shi^*, Xiangming Chen^*, Wenzhi Liu^*, Lin Wei^*

Oncology Research, Vol.23, No.4, pp. 197-203, 2015, DOI:10.3727/096504016X14537290676919

Abstract Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in gastric cancer remains unknown. In the current study, we showed that FGF19 is overexpressed in gastric cancer and is associated with depth of invasion, lymph node metastasis, and TNM stage. In addition, in vitro experiments demonstrated that More >

Donghui Zhang^*1, Genling Yang^†1, Xidong Li^‡, Cheng Xu^*, Honglei Ge^§

Oncology Research, Vol.23, No.4, pp. 171-181, 2015, DOI:10.3727/096504016X14519995067562

Abstract Cullin7 is an E3 ubiquitin ligase. The Cullin7 protein family functions as a molecular scaffold to coordinate substrate ubiquitination in Skp, Cullin, and F-box-containing complex (SCF complex). Cullin7s control normal development and primary cellular processes and are characterized by a unique genomic network organization. Less is known about the involvement of Cullin7 with hepatocellular carcinoma (HCC). In this study, we found that Cullin7 showed a high expression in HCC tumor tissues, especially in metastatic HCC tumor tissues. Also, there was a negative correlation between Cullin7 expression and long survival. Silencing of Cullin7 in liver cancer More >

Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xinguang Qiu

Oncology Research, Vol.23, No.4, pp. 165-170, 2015, DOI:10.3727/096504016X14519157902726

Abstract Accumulating evidence has reported the significant role of miRNAs in the underlying biology of tumors, including breast cancer. The purpose for this study was to investigate the potential effects of miR-544a in breast cancer migration and invasion. The human normal breast Hs578Bst cells and the human breast cancer MCF-7 and MDA-MB-231 cells were used to analyze the expression of miR-544a by RT-PCR. The effects of miR-544a on the two kinds of breast cancer cell migration and invasion were analyzed using the Matrigel and Transwell assay, respectively. miR-544a expression on the cell metastasis-related protein expression was More >

Ming Liu, Dan Wang, Ning Li

Oncology Research, Vol.23, No.5, pp. 257-266, 2015, DOI:10.3727/096504016X14562725373752

Abstract Osteosarcoma (OS) is the most common malignant primary bone tumor disease. HIF-1α was predicted to be the target gene of microRNA-20b (miR-20b). The present study was designed to illustrate the effect of miR- 20b in regulating osteosarcoma via targeting HIF-1α. In this study, we found that the expression of HIF-1α was significantly increased, while miR-20b obviously decreased in OS patients and OS cell lines compared with healthy controls. Moreover, the luciferase report confirmed the targeting reaction between miR-20b and HIF-1α. Additionally, the overexpression of miR-20b suppressed the invasion and growth of both MG63 and U2OS More >

Hongtao Ren^*, Zhongwei Wang^*, Shuqun Zhang^*, Hongbing Ma^*, Yali Wang^*, Lijun Jia^*, Yiming Li^†

Oncology Research, Vol.23, No.5, pp. 249-256, 2015, DOI:10.3727/096504016X14562725373716

Abstract Interleukin-17A (IL-17A) plays a significant role in many inflammatory diseases and cancers. The aim of this study is to investigate the effect of IL-17A on the invasiveness of colorectal cancer. In the study, we found that IL-17A could promote the migration and invasion of colorectal cancer cells. Furthermore, after being treated with IL-17A, the expression and activity of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated. Moreover, the nuclear/overall fractions and DNA-binding activity of p65 and p50 were dramatically elevated by IL-17A. Pretreatment with a nuclear factor-kB (NF-kB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002) was More >

Jianyu Zhou^*, Xiaorong Li^*, Meirong Wu^†, Changwei Lin^*, Yihang Guo^*, Buning Tian^*

Oncology Research, Vol.23, No.6, pp. 303-309, 2015, DOI:10.3727/096504016X14567549091305

Abstract Emerging evidence has identified the vital role of long noncoding RNAs (lncRNAs) in the development of colorectal cancer. In this study, we aimed to investigate the role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in colorectal cancer. We analyzed the expression of GHET1 in colorectal cancer (CRC) tissues by using ISH. We found that GHET1 expression was significantly increased in the CRC samples compared with adjacent tissues. Furthermore, the cancer tissues had higher GHET1 mRNA levels than their matched adjacent tissues. GHET1 expression was also significantly increased in the CRC cell lines compared More >

Carlos H. Martinez¹, Andrew K. Williams¹, Joseph L. Chin¹, Larry Stitt², Jonathan I. Izawa¹

Canadian Journal of Urology, Vol.20, No.2, pp. 6696-6701, 2013

Abstract Introduction: Clinical variables with more accuracy to predict biologically insignificant prostate cancer are needed. We evaluated the combination of transrectal ultrasound-guided biopsy of the prostate (TRUSBx) pathologic and radiologic findings in their ability to predict the biologic potential of each prostate cancer.
Materials and methods: A total of 1043 consecutive patients who underwent TRUSBx were reviewed. Using pathologic criteria, patients with prostate cancer (n = 529) and those treated with radical prostatectomy (RP) (n = 147) were grouped as: “insignificant” (Gleason score ≤ 6, prostate-specific antigen (PSA) density ≤ 0.15 ng/mL, tumor in ≤ 50% of any… More >

Malik Elharram¹, David Margel², Antonio Finelli², John Trachtenberg², Andrew Evans³, Theodorus H. van der Kwast³, Joan M. Sweet², Neil Fleshner²

Canadian Journal of Urology, Vol.19, No.6, pp. 6567-6572, 2012

Abstract Introduction: The clinical significance of perineural invasion (PNI) on prostate needle biopsy is controversial. The aim of this present study is to determine the role of PNI on prostate biopsy in predicting adverse findings at radical prostatectomy in a recent cohort of screen detected prostate cancer.
Materials and methods: We analyzed 470 patients diagnosed with prostate cancer from a prospectively maintained database at Princess Margaret Hospital. Out of the 470 patients diagnosed with prostate cancer, 139 underwent radical prostatectomy. Pathological specimens were examined, and perineural invasion was identified as carcinoma tracking along or around a nerve in… More >

George R. Schade, Ofer N. Gofrit, Kevin C. Zorn

Canadian Journal of Urology, Vol.15, No.2, pp. 4012-4015, 2008

Abstract A 42-year-old woman with tuberous sclerosis (TS)presented with acute right-sided flank pain. Imaging studies demonstrated numerous bilateral renal angiomyolipomas (AML), the largest located within the right upper pole, extending into the venous system to the level of the infra-hepatic inferior vena cava (IVC).Intravascular extension of AML is quite rare, however,may potentially result in fatal complications if not appropriately treated. We present a case report and a description of the surgical management, and provide a review of the literature concerning this rare finding. More >