Daniel A. Wollin¹, Fang-Ming Deng², William C. Huang¹, James S. Babb³, Andrew B. Rosenkrantz³

Canadian Journal of Urology, Vol.21, No.5, pp. 7454-7459, 2014

Abstract Introduction: To compare qualitative and quantitative imaging features from conventional and diffusion-weighted (DW) magnetic resonance imaging (MRI) in detection of metastatic pelvic lymph nodes in bladder cancer patients undergoing cystectomy.
Materials and methods: Thirty-six patients who had undergone cystectomy for bladder cancer with preoperative MRI with DWI sequence prior to surgery were included. Imaging features on conventional and DW-MRI were compared with histopathology at cystectomy.
Results: Nodal features associated with metastatic lymphadenopathy were short axis (AUC = 0.85, p < 0.001; when SA > 5 mm: sensitivity = 88%, specificity = 75%), long axis (AUC =… More >

Moustafa Hamze, Caroline Desmetz, Paul Guglielmi

European Cytokine Network, Vol.24, No.1, pp. 20-26, 2013, DOI:10.1684/ecn.2013.0327

Abstract B cells regulate immune responses during infectious, inflammatory and autoimmune diseases. Beside their unique and characteristic antibody production, B lymphocytes can modulate physiological and pathological processes by presenting antigens or synthesizing signaling molecules. In human and mouse diseases, immunointervention, targeting B cells, has revealed and highlighted their antibody-independent regulatory contribution. In this review, we focus on B cell-cytokine production, which is commonly disturbed in inflammatory disorders, and describe the B cell cytokine profile in different diseases. Finally, we discuss some key issues for future B cell-targeted therapies. More >

Wenli Zhuo, Jinqian Chai, Tingzhao Xu, Weizhen Wu, Shunliang Yang, Jianming Tan

Canadian Journal of Urology, Vol.20, No.2, pp. 6726-6729, 2013

Abstract Introduction: To report our preliminary techniques and experience with retroperitoneoscopic single-site renal pedicle lymphatic disconnection (RPSS-RPLD) in five patients with serious filarial chyluria.
Materials and methods: Between May 2010 and July 2011, five patients with serious filarial chyluria underwent RPSS-RPLD. In each patient, a 3 cm single incision was made between the 12th subcostal margin and posterior axillary line, and a homemade single multichannel port using a surgical glove and three conventional trocars was placed into the retroperitoneal space. The lymphatic disconnection procedure was similar to that of traditional open surgery.
Results: All operations were successfully completed without More >

Michael W. Sourial¹, Nicole van Rossum², Robert Sabbagh¹

Canadian Journal of Urology, Vol.20, No.5, pp. 6968-6970, 2013

Abstract We herein report the case of a left adrenal lymphangioma in a 52-year-old asymptomatic female and review the pertinent literature relatable to this rare, benign lesion. More >

Mahboobeh Razmkhah¹, Mansoureh Jaberipour¹, Akbar Safaei², Abdol-Rasoul Talei³, Nasrollah Erfani¹, Abbass Ghaderi^1,4

European Cytokine Network, Vol.23, No.3, pp. 72-77, 2012, DOI:10.1684/ecn.2012.0310

Abstract Background: Lymph nodes (LNs) are among the first sites of tumor metastasis. The expression of chemokines and chemokine receptors in LNs are involved in cancer prognosis and are considered to be good predictors of tumor progression. The main aim of this study was to assess the expression of important, tumorpromoting chemokines and chemokine receptors in LNs of breast cancer patients. Methods: LNs were isolated from eighteen women diagnosed with breast cancer. Data were compared between positive and negative LNs. Expression of chemokines and chemokine receptors were determined by quantitative real-time PCR (qRT-PCR) and flow cytometry.… More >

Yves Collin¹, Anne Méziat-Burdin², Robert Sabbagh³

Canadian Journal of Urology, Vol.19, No.2, pp. 6204-6206, 2012

Abstract Laparoscopic indications are still growing due to the acquisition and development of new skills and expertise in the laparoscopic field. We report the first case of a successful transperitoneal right radical nephrectomy after intraperitoneal hyperthermic chemotherapy in a 56-year-old female who previously underwent multiple abdominal surgeries for appendicular adenocarcinoma with pseudomyxoma peritonei. In patients with multiples previous abdominal surgeries and intraperitoneal chemotherapy, transperitoneal laparoscopic surgeries are feasible in experienced hands. However, patient safety is paramount and conversion to open surgery should always be considered in case of complications. More >

Yachao Zhang, Timothy Byler, Steve Landas, Margaret Ekroth, Oleg Shapiro

Canadian Journal of Urology, Vol.19, No.2, pp. 6201-6203, 2012

Abstract A 29-year-old man presented with a right testicular mass. Serum tumor markers were within normal limits. When compared to a previous computed tomography (CT) scan, a new 4 cm presacral mass was present. He underwent radical right inguinal orchiectomy that demonstrated a mature teratoma and seminomatous components. The patient received four cycles of chemotherapy. Over the courseofchemotherapy,themassgrewinsizeandtherefore he underwent retroperitoneal lymph node dissection. Pathology confrmed it to be a teratoma with negative retroperitoneal lymph nodes. The unusual presentation of an isolated metastasis to the presacral region raises the question of altered lymphatic drainage. More >

Lindsey A. Herrel¹, Ryan M. Butterworth², Syed M. Jafri¹, Carl Ying¹, Keith A. Delman³, David A. Kooby³, Kenneth E. Ogan¹, Daniel J. Canter¹, Viraj A. Master¹

Canadian Journal of Urology, Vol.19, No.3, pp. 6306-6309, 2012

Abstract Inguinal lymphadenectomy plays a critical role in the diagnosis and treatment of several neoplastic diseases. Frequently, bilateral lymphadenectomy is undertaken for staging and/or treatment of genitourinary cancers. Our objective was to determine if bilateral endoscopic lymphadenectomy could be performed simultaneously, in an effort to decrease overall anesthetic and operative time. This was accomplished by utilizing two carbon dioxide insufflators concurrently. This approach requires careful positioning of the patient, surgical team, and instrumentation, as well as special anesthetic considerations necessary to avoid severe hypercarbia. Simultaneous bilateral endoscopic inguinal lymphadenectomy is a technically feasible and efficient surgical More >

Jeffrey K. Mullins, Phillip M. Pierorazio, Elias S. Hyams, Sally E. Mitchell, Mohamad E. Allaf

Canadian Journal of Urology, Vol.19, No.3, pp. 6250-6254, 2012

Abstract Introduction: We report the outcomes of a small series of patients with refractory chylous ascites following urologic surgery treated with lymphangiography +/- sclerotherapy.
Materials and methods: Retrospective review revealed three patients who underwent lymphangiography for prolonged lymphatic leak following urological surgery. Contrast material is injected slowly into a lymphatic vessel on the dorsum of the foot and serial imaging is used to capture the location and degree of lymphatic leak in order to guide definitive treatment. Demographic and clinical details were collected and are reported.
Results: Three patients were identified from 2005-2008 (one following donor nephrectomy and two… More >

Adam Luchey, Stanley Zaslau, Can Talug

Canadian Journal of Urology, Vol.19, No.4, pp. 6389-6391, 2012

Abstract Paraganglioma of the urinary bladder is a rare tumor that often presents with hypertensive crisis during micturition. We herein present the unusual case of a 45-year-old female with metastatic paraganglioma treated with robotic-assisted partial cystectomy and pelvic lymphadenectomy. We review the literature regarding the evaluation and management of paraganglioma of the bladder. More >