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  • Open Access

    ARTICLE

    Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

    Aknur Turgumbayeva1,2, Gulbaram Ustenova1, Ubaidilla Datkhayev1, Khairolla Rahimov3, Silvijus Abramavicius4,5, Agile Tunaityte4,*, Kairat Zhakipbekov1,6, Kaldanay Kozhanova1, Saken Tulemissov7, OzikhanUstenova8, Gulmira Datkayeva9, Edgaras Stankevicius1,10

    Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665

    Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the More >

  • Open Access

    ARTICLE

    Antimalarial drug artesunate aff ords protection against carrageenan induced acute infl ammation in rat

    Vijay L. KUMAR1 *, B. GURUPRASAD1, Priyanka CHAUDHARY2

    BIOCELL, Vol.38, No.1, pp. 1-6, 2014, DOI:10.32604/biocell.2014.38.001

    Abstract Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of artesunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of 0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE2 and myeloperoxidase More >

  • Open Access

    ABSTRACT

    A numerical model to study hemodynamics arising from malaria infection

    Yohsuke Imai, Hitoshi Kondo, Young Ho KANG, Takuji Ishikawa Chwee Teck Lim, Takami Yamaguchi

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 205-206, 2009, DOI:10.3970/icces.2009.009.205

    Abstract Malaria is one of the most serious infectious diseases on earth. We have about five hundred million patients with two million deaths. When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent. We propose a numerical model of hemodynamics arising from malaria infection. Our model is based on a Lagrangian and free mesh method (particle) method. A spring network model is employed to compute elastic force generated by the deformation of IRBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by More >

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