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  • Open Access

    ARTICLE

    Nanomechanical Properties of Electrospun PLGA Nanofibers

    X. Xin1, M. Hussain1, J. Mao1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 187-188, 2006, DOI:10.32604/mcb.2006.003.187

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    The Effect of Processing Temperature on Mechanical Properties of Novel Silk Fibroin and Chitosan Blend Scaffolds for Musculoskeletal Regeneration

    C. N. Rios1, J. N. Augustine1, A. B. Mathur1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 173-174, 2006, DOI:10.32604/mcb.2006.003.173

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Optimizing the Mechanical Stimulus in Culture to Improve Construct Biomechanics for Tendon Repair

    V. S. Nirmalanandhan1, J. T. Shearn1, N. Juncosa-Melvin1, M. Rao1, A. Jain1, C. Gooch1, D. L. Butler1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 131-134, 2006, DOI:10.32604/mcb.2006.003.131

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Regulation of Vascular Smooth Muscle Cells and Mesenchymal Stem Cells by Mechanical Strain

    Kyle Kurpinski1,2,3, Jennifer Park1,2,3, Rahul G. Thakar1,2,3, Song Li1,2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 21-34, 2006, DOI:10.3970/mcb.2006.003.021

    Abstract Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to More >

  • Open Access

    ARTICLE

    Substrate Modulation of Osteoblast Adhesion Strength, Focal Adhesion Kinase Activation, and Responsiveness to Mechanical Stimuli

    E. Takai1, R. Landesberg2, R.W. Katz2, C.T. Hung3, X.E Guo1,4

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 1-12, 2006, DOI:10.3970/mcb.2006.003.001

    Abstract Osteoblast interactions with extracellular matrix (ECM) proteins are known to influence many cell functions, which may ultimately affect osseointegration of implants with the host bone tissue. Some adhesion-mediated events include activation of focal adhesion kinase, and subsequent changes in the cytoskeleton and cell morphology, which may lead to changes in adhesion strength and cell responsiveness to mechanical stimuli. In this study we examined focal adhesion kinase activation (FAK), F-actin cytoskeleton reorganization, adhesion strength, and osteoblast responsiveness to fluid shear when adhered to type I collagen (ColI), glass, poly-L-lysine (PLL), fibronectin (FN), vitronectin (VN), and serum… More >

  • Open Access

    ARTICLE

    Thermomechanical Analysis of Functionally Graded Composites under Laser Heating by the MLPG Method

    H. K. Ching1,2, J. K. Chen2

    CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.3, pp. 199-218, 2006, DOI:10.3970/cmes.2006.013.199

    Abstract The Meshless Local Petrov-Galerkin (MLPG) method is a novel numerical approach similar to finite element methods, but it allows the construction of the shape function and domain discretization without defining elements. In this study, the MLPG analysis for transient thermomechanical response of a functionally graded composite heated by Gaussian laser beams is presented. The composite is modeled as a 2-D strip which consists of metal and ceramic phases with the volume fraction varying over the thickness. Two sets of the micromechanical models are employed for evaluating the effective material properties, respectively. Numerical results are presented More >

  • Open Access

    ARTICLE

    Micro-macro Approaches Coupled to An Iterative Process for Nonlinear Porous Media

    S. Smaoui1, A. Ben Hamida1, I. Djeran-Maigre2, H. Dumontet1

    CMC-Computers, Materials & Continua, Vol.4, No.3, pp. 153-162, 2006, DOI:10.3970/cmc.2006.004.153

    Abstract An iterative homogenization approach is proposed in order to predict the nonlinear hydro-mechanical behaviour of porous media. This process is coupled to classical and modified secant extended methods and linear homogenization predictive schemes. At convergence of the iterative process, same equivalent behaviour is obtained for any secant method, any simplified homogenization used for the linear comparison material and for any initial porosity of the media. An application to the study of the nonlinear behaviour of clayey sediments is presented. The model parameters quantification is based on oedometric experimental results for different clays. More >

  • Open Access

    ARTICLE

    Asymptotic Solutions for Multilayered Piezoelectric Cylinders under Electromechanical Loads

    Chih-Ping Wu1, Yun-Siang Syu

    CMC-Computers, Materials & Continua, Vol.4, No.2, pp. 87-108, 2006, DOI:10.3970/cmc.2006.004.087

    Abstract Based on the three-dimensional (3D) piezoelectricity, we presented asymptotic solutions for multilayered piezoelectric hollow cylinders using the method of perturbation. The material properties in the general formulation are firstly regarded to be heterogeneous through the thickness, and then specified as the layerwise step functions in the cases of multilayered cylinders. The transverse normal load and normal electric displacement are respectively applied on the lateral surfaces of the cylinders. The boundary conditions of cylinders are considered to be simply supported at the two edges. In the formulation the twenty-two basic equations of piezoelectricity are reduced to More >

  • Open Access

    ARTICLE

    Finite Element modeling of Nomex® honeycomb cores : Failure and effective elastic properties

    L. Gornet1, S. Marguet2, G. Marckmann3

    CMC-Computers, Materials & Continua, Vol.4, No.2, pp. 63-74, 2006, DOI:10.3970/cmc.2006.004.063

    Abstract The purpose of the present study is to determine the components of the effective elasticity tensor and the failure properties of Nomex® honeycomb cores. In order to carry out this study, the NidaCore software, a program dedicated to Nomex®Cores predictions, has been developed using the Finite Element tool Cast3M-CEA. This software is based on periodic homogenization techniques and on the modelling of structural instability phenomena. The homogenization of the periodic microstructure is realized thanks to a strain energy approach. It assumes the mechanical equivalence between the microstructures of a RVE and a similar homogeneous macroscopic volume.… More >

  • Open Access

    ARTICLE

    A Frequency Method for Fatigue Life Estimation of Mechanical Components under Bimodal Random Stress Process

    C. Braccesi1, F. Cianetti1, G. Lori1, D. Pioli1

    Structural Durability & Health Monitoring, Vol.1, No.4, pp. 277-290, 2005, DOI:10.3970/sdhm.2005.001.277

    Abstract This paper describes an original frequency method for fatigue life estimation of mechanical components subjected to random inputs. Currently mechanical components life design under random loads is an important task of the research, due to the increasing importance of virtual simulation in opposition to the experimental tests. The frequency domain approach, in this context, seems to be able to supply reliable estimations with small computational effort. The proposed method belongs to the class of corrective coefficient to narrow-band formula methods and it has been thought for bimodal PSDs. The definition of the generalized bimodal processes and More >

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