Hamayun Khan^1,*, Muhammad Atif Imtiaz², Hira Siddique³, Muhammad Tausif Afzal Rana⁴, Arshad Ali⁵, Muhammad Zeeshan Baig⁶, Saif ur Rehman⁷, Yazed Alsaawy⁵

Computer Systems Science and Engineering, Vol.49, pp. 317-331, 2025, DOI:10.32604/csse.2025.061118 - 19 March 2025

Abstract The migration of tasks aided by machine learning (ML) predictions IN (DPM) is a system-level design technique that is used to reduce energy by enhancing the overall performance of the processor. In this paper, we address the issue of system-level higher task dissipation during the execution of parallel workloads with common deadlines by introducing a machine learning-based framework that includes task migration using energy-efficient earliest deadline first scheduling (EA-EDF). ML-based EA-EDF enhances the overall throughput and optimizes the energy to avoid delay and performance degradation in a multiprocessor system. The proposed system model allocates processors… More >

Lingling Zhang^1,2, Hualing Wang³, Yawen Liu², Ling Li^2,*, Jianping Xiong^1,4,*

BIOCELL, Vol.49, No.2, pp. 253-267, 2025, DOI:10.32604/biocell.2025.061585 - 28 February 2025

Abstract Objective: Anillin (ANLN) is considered an oncogene in various cancers, but its effect on cervical cancer remains poorly understood. Hence, this study aimed to describe the action of ANLN on cervical cancer development and investigate the potential mechanism. Methods: Analysis of ANLN expression and its association with survival in carcinoma and endocervical adenocarcinoma (CESC) patients based on GEO and UALCAN databases. The tumor and adjacent normal tissues of 100 cervical cancer cases were harvested to detect the ANLN expression and explore its relationship with patient survival. Cell proliferation, apoptosis, migration, and invasion were measured by… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

Abstract This article has no abstract. More >

NAIXIONG PENG, YUEFENG CAI, DONG CHEN, LING DENG, ZEJIAN ZHANG, WEI LI^*

Oncology Research, Vol.33, No.2, pp. 347-356, 2025, DOI:10.32604/or.2024.056039 - 16 January 2025

Abstract Background: Clear cell renal carcinoma (ccRCC), the leading histological subtype of RCC, lacks any targeted therapy options. Although some studies have shown that early growth response factor 1 (EGR1) has a significant role in cancer development and progression, its role and underlying mechanisms in ccRCC remain poorly understood. Methods: The Cancer Genome Atlas (TCGA) database was utilized to examine the expression of EGR1 in ccRCC. The expression of EGR1 in 55 ccRCC tissues was evaluated using immunohistochemistry. The link between EGR1 expression and clinicopathological variables was examined through an analysis. Gain-of-function assays were employed to… More >

HUNG-WEI LIN¹, PEI YU LEE¹, YU-SHIUAN CHANG¹, MAU-SUN CHANG^1,2,*

Oncology Research, Vol.33, No.2, pp. 493-503, 2025, DOI:10.32604/or.2024.053791 - 16 January 2025

Abstract Background: Rho GTPases are essential regulators for cellular movement and intracellular membrane trafficking. Their enzymatic activities fluctuate between active GTP-bound and inactive GDP-bound states regulated by GTPase activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Arhgap39/Vilse/Porf-2 is a newly identified GAP. The role of Arhgap39 in migration and invasion has not been addressed thoroughly. Methods: The Arhgap39 gene was knocked out by Crispr-Cas9 gene editing in mouse Hepa1-6 and Hepa-1c1c7 cells to analyze the impact of Arhgap39 depletion on migration and invasion. Results: Loss of Arhgap39 noticeably increased the migration and invasive potential. Purified Arhgap39… More >

WEN YANG, BIN TANG, DAN XU, WENXIU YANG^*

Oncology Research, Vol.33, No.1, pp. 199-212, 2025, DOI:10.32604/or.2024.050036 - 20 December 2024

Abstract Background: The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood. Methods: Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups. Immunohistochemical data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of DLBCL. Furthermore, in vitro and in vivo experiments were conducted to clarify the… More > Graphic Abstract

YUAN YIN¹, ZHENGYIN WANG¹, YUJIE HU¹, JIA WANG¹, YI WANG^2,*, QUN LU^1,*

Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

Zongze Li¹, Zirui Yang², Yue Wu³, Chunming He⁴, Bo Yu², Daobing Wang^2,*, Yueshe Wang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-4, 2024, DOI:10.32604/icces.2024.012090

Abstract Geothermal energy is an important renewable energy source, where hot dry rock (HDR) constitutes the primary component, accounting for approximately 90% of the resource. Therefore, the establishment of an efficient HDR geothermal utilization system is a core issue in geothermal resource development. Hydraulic fracturing (HF) technology serves as a crucial means aimed at enhancing the complexity of underground fracture networks and increasing heat exchange efficiency, thus improving the performance of HDR geothermal utilization systems. However, the fracture structure formed by conventional HF techniques is relatively simple, resulting in limited heat exchange areas. Hence, the temporary… More >

Marat Satayev^1,2,*, Abdugani Azimov², Arnold Brener², Nina Alekseyeva¹, Zulfia Shakiryanova²

Frontiers in Heat and Mass Transfer, Vol.22, No.5, pp. 1533-1558, 2024, DOI:10.32604/fhmt.2024.052901 - 30 October 2024

Abstract The goal of this work is, first of all, to construct a mathematical model of the mass transfer process in porous adsorption layers, taking into account the fact that in most cases the adsorption process is carried out in non-stationary technological modes, which requires a clear description of its various stages. The scientific contribution of the novel model is based on a probability approach allowing for deriving a differential equation that takes into account the diffusion migration of adsorbed particles. Solving this equation allows us to calculate the reduced degree of the adsorption surface coverage… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1829-1829, 2024, DOI:10.32604/or.2024.056904 - 16 October 2024

Abstract This article has no abstract. More >