Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1383-1383, 2024, DOI:10.32604/or.2024.055036 - 17 July 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1381-1381, 2024, DOI:10.32604/or.2024.055035 - 17 July 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1375-1375, 2024, DOI:10.32604/or.2024.055032 - 17 July 2024

Abstract This article has no abstract. More >

XULONG SUN^1,#, WENTAO DING^2,#, CHAO JIANG³, ZHIAN FANG^4,*

BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519 - 03 July 2024

Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

YAN-NAN LI^1,#, YUN-HONG XIU^2,#, YAN-JUN TANG³, JING-LONG CAO¹, WEN-SHUANG HOU¹, AN-QI WANG¹, TIAN-ZHU LI^4,*, CHENG-HAO JIN^1,3,5,*

BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515 - 03 July 2024

Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

CHUNLING LIANG^1,#, JING CHEN^2,#, XIAOJIE CHEN¹, WEI YAN³, JIE YU^4,*

BIOCELL, Vol.48, No.7, pp. 1105-1113, 2024, DOI:10.32604/biocell.2024.050509 - 03 July 2024

Abstract Background: A differential gene, triggering receptor expressed on myeloid cells 1 (TREM1), was identified in blood sequencing datasets from myocardial infarction patients and healthy controls. Myocardial fibrosis following myocardial infarction significantly contributes to cardiac dysfunction. Objectives: This study aimed to unveil the intrinsic regulatory mechanism of TREM1 in myocardial fibrosis. Methods: Mimicking pathology by angiotensin II (Ang II) treatment of human cardiac fibroblasts (HCFs), the impacts of TREM1 knockdown on its proliferation, migration, and secretion of the pro-fibrotic matrix were identified. Using the Human Transcription Factor Database (HumanTFDB) website, lysine-specific demethylase 5B (KDM5B) was found to… More >

ZHAOYING ZHU^1,#, YANJIA HU^2,#, FENG YE², HAIBO TENG², GUOLIANG YOU¹, YUNHUI ZENG², MENG TIAN², JIANGUO XU², JIN LI², ZHIYONG LIU², HAO LIU^2,*, NIANDONG ZHENG^1,*

Oncology Research, Vol.32, No.7, pp. 1173-1184, 2024, DOI:10.32604/or.2024.042456 - 20 June 2024

Abstract Background: Inhibitor of NF-κB kinase-interacting protein (IKIP) is known to promote proliferation of glioblastoma (GBM) cells, but how it affects migration and invasion by those cells is unclear. Methods: We compared levels of IKIP between glioma tissues and normal brain tissue in clinical samples and public databases. We examined the effects of IKIP overexpression and knockdown on the migration and invasion of GBM using transwell and wound healing assays, and we compared the transcriptomes under these different conditions to identify the molecular mechanisms involved. Results: Based on data from our clinical samples and from public databases, More >

Yao Wang¹, Xiaojiao Li², Panpan Yang^1,*, Zengyan Yu^1,*

International Journal of Mental Health Promotion, Vol.26, No.5, pp. 335-343, 2024, DOI:10.32604/ijmhp.2024.048483 - 30 May 2024

Abstract Social anxiety is a common psychological problem among left-behind children (LBC) and has been a popular issue in recent years. Children with higher levels of social anxiety have more emotional and behavioral problems and are prone to negative life events. Although several studies have explored the differences in social anxiety between LBC and non-left-behind children (N-LBC), the findings have not been consistent. In this study, a systematic review and meta-analysis method was used, with 411 papers retrieved on October 01, 2023, from Pubmed, Embase, Web of Science, and Chinese databases (CNKI, VIP, and Wanfang) (PROSPERO… More >

Azad Hussain¹, Saira Raiz¹, Ali Hassan^1,2,*, Mohamed R. Ali³, Abdulkafi Mohammed Saeed⁴

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 433-453, 2024, DOI:10.32604/fhmt.2024.044121 - 20 May 2024

Abstract Heat transfer improves significantly when the working fluid has high thermal conductivity. Heat transfer can be found in fields such as food processing, solar through collectors, and drug delivery. Considering this notable fact, this work is focused on investigating the bio-convection-enhanced heat transfer in the existence of convective boundary conditions in the flow of hybrid nanofluid across a stretching surface. Buongiorno fluid model with hybrid nanoparticles has been employed along the swimming microorganisms to investigate the mixture base working fluid. The developed nonlinear flow governing equations have been tackled numerically with the help of the… More > Graphic Abstract

XINRU FENG¹, LI XIAO^2,*

BIOCELL, Vol.48, No.5, pp. 793-801, 2024, DOI:10.32604/biocell.2024.048395 - 06 May 2024

Abstract Background: Galectin 2 (LGALS2) is a protein previously reported to serve as a mediator of disease progression in a range of cancers. The function of LGALS2 in oral squamous cell carcinoma (OSCC), however, has yet to be explored, prompting the present study to address this literature gap. Methods: Overall, 144 paired malignant tumor tissues and paracancerous OSCC patient samples were harvested and the LGALS2 expression levels were examined through qPCR and western immunoblotting. The LGALS2 coding sequence was introduced into the pcDNA3.0 vector, to enable the overexpression of this gene, while an LGALS2-specific shRNA and… More >