Cheng Dong^1,2,3, Margaret J. Slattery^2,3, Shile Liang³, Hsin-Hsin Peng²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 145-160, 2005, DOI:10.3970/mcb.2005.002.145

Abstract Attachment of tumor cells to the endothelium (EC) under flow conditions is critical for the migration of tumor cells out of the vascular system to establish metastases. Innate immune system processes can potentially promote tumor progression through inflammation dependant mechanisms.\nobreakspace {} White blood cells, neutrophils (PMN) in particular, are being studied to better understand how the host immune system affects cancer cell adhesion and subsequent migration and metastasis. Melanoma cell interaction with the EC is distinct from PMN-EC adhesion in the circulation. We found PMN increased melanoma cell extravasation, which involved initial PMN tethering on… More >

Marcello Lappa ¹

CMC-Computers, Materials & Continua, Vol.2, No.1, pp. 51-64, 2005, DOI:10.3970/cmc.2005.002.051

Abstract A possible approach for the investigation of a number of aspects related to the processing of immiscible alloys, made possible by recent progress in both fields of moving boundary (VOF) methods and speed of computers, is discussed. It can capture in a single numerical treatment and without limiting assumptions both macroscopic information (i.e. the macrophysical problem, heretofore treated in terms of population dynamics) and microscopic details (i.e. the microphysical problem, heretofore treated within the framework of boundary integral methods and/or under the assumption of nondeformable drops). The role played by coalescence in changing the Marangoni More >

S.-C. Hsiao¹, M.S. Ingber²

CMC-Computers, Materials & Continua, Vol.1, No.1, pp. 51-58, 2004, DOI:10.3970/cmc.2004.001.051

Abstract The lateral migration of nonneutrally-buoyant spherical particles in Poiseuille flow is investigated numerically using the boundary element method. In particular, the steady, Navier-Stokes equations are solved using a classical domain integration method treating the nonlinear terms as pseudo-body forces. The numerical results for the lateral migration velocity are compared with experimental data. The numerical results indicate that the lateral migration velocity does not scale linearly with the Reynolds number. The methodology is extended to include non-Newtonian power-law fluids. The migration velocity is significantly affected for particles suspended in this class of fluids and can actually More >

T. Iwasaki¹ and H. Miura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.5, pp. 551-558, 2003, DOI:10.3970/cmes.2003.004.551

Abstract We have developed a molecular-dynamics technique for investigating migration-induced failures in interconnect films for ULSIs. This technique was used to simulate grain-boundary grooving in Al and Cu films. The simulations showed that the grain-boundary grooves are formed by atomic diffusion at the grain boundary. To clarify what kind of underlay material is effective in suppressing this diffusion, we calculated the dependence of groove depth on the kind of underlay material. The calculation showed that the groove depth of the Al film decreases in the order: Al/Ta, Al/W, and Al/TiN while that of the Cu film More >