Oncology Research Editorial Office

Oncology Research, Vol.33, No.10, pp. 3157-3157, 2025, DOI:10.32604/or.2025.073033 - 26 September 2025

Abstract This article has no abstract. More >

Shiyang Zhang^1,#, Jingchen Li^1,#, Qianxu Jin², Siyu Zhu¹, Hongshan Yan², Yizheng Wang³, Zihan Song¹, Liqiang Liu^1,*

Oncology Research, Vol.33, No.10, pp. 2961-2979, 2025, DOI:10.32604/or.2025.064300 - 26 September 2025

Abstract Background: Glioma is the most common tumor of the central nervous system with a poor prognosis. This study aims to explore the role of calcium/calmodulin-dependent protein kinase IIβ (CAMK2B) in regulating the malignant progression of glioma cells, as well as the molecular mechanisms underlying these malignant behaviors. Methods: The correlation between CAMK2B expression in gliomas and patient prognosis was analyzed using immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and western blot. Furthermore, the study explored the role of CAMK2B in glioma cell proliferation, invasion, and migration using cell counting kit-8 (CCK-8), 5-Ethynyl-2^′-deoxyuridine (EdU), wound healing,… More >

Xinyu Yu¹, Lucheng Chen^2,3, Xingzhi Feng^2,4, Xiaoping Lu^2,4,*, Yuye Yang¹, You Shi^5,*

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3231-3252, 2025, DOI:10.32604/cmc.2025.066975 - 23 September 2025

Abstract This paper investigates mobility-aware online optimization for digital twin (DT)-assisted task execution in edge computing environments. In such systems, DTs, hosted on edge servers (ESs), require proactive migration to maintain proximity to their mobile physical twin (PT) counterparts. To minimize task response latency under a stringent energy consumption constraint, we jointly optimize three key components: the status data uploading frequency from the PT, the DT migration decisions, and the allocation of computational and communication resources. To address the asynchronous nature of these decisions, we propose a novel two-timescale mobility-aware online optimization (TMO) framework. The TMO… More >

Yan Song^1,2,3,#, Yiting Chen^4,#, Xiaojing Li², Peng Pan², Ningfan Hu², Lanyi Wei², Yue Xiao^1,3,*, Chaogang Wei^2,*

BIOCELL, Vol.49, No.7, pp. 1207-1223, 2025, DOI:10.32604/biocell.2025.065658 - 25 July 2025

Abstract Objectives: Progression to castration-resistant prostate cancer (CRPC) and metastasis are the greatest challenges to effective treatment. Anticancer strategies targeting the key kinases associated with the development of CRPC may represent a breakthrough. The tyrosine kinase receptor Erythropoietin-producing hepatocellular (Eph) A2 receptor is highly expressed in CRPC cell lines and may be associated with tumor invasion and metastasis. However, the effects and exact mechanisms of EphA2 in CRPC are only partially understood. This study aimed to investigate the impact of EphA2 on CRPC cell behaviors and underlying molecular pathways Methods: CRISPR/Cas9-mediated gene editing induced EphA2-disrupted in… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.8, pp. 2175-2175, 2025, DOI:10.32604/or.2025.070131 - 18 July 2025

Abstract This article has no abstract. More >

JONG-HYUK AHN¹, JIN WOOK YI^2,3,*

Oncology Research, Vol.33, No.8, pp. 1909-1931, 2025, DOI:10.32604/or.2025.065847 - 18 July 2025

Abstract Background: With growing interest in space exploration, understanding microgravity’s impact on human health is essential. This study aims to investigate gene expression changes and migration and invasion potential in five thyroid-related cell lines cultured under simulated microgravity. Methods: Five thyroid-related cell lines—normal thyrocytes (Nthy-ori 3-1), papillary thyroid cancer (PTC) cells (SNU-790, TPC-1), poorly differentiated thyroid cancer cell (BCPAP), and anaplastic thyroid cancer cell (SNU-80)—were cultured under simulated microgravity (10⁻³ g) using a clinostat. Differentially expressed genes (DEGs) were analyzed using cDNA microarray, followed by functional annotation and assessment of aggressiveness via Transwell migration and invasion assays.… More >

Li Yu^1,2,3, Xiaoyan Zhang^1,2, Yan Feng^1,4, Xinyue Liao^1,4, Tiejun Zhou⁵, Hang Si^1,4, Yun Feng^1,4, Decai Wang^6,*, Yongxian Lai^1,7,*

Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025

Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

Siji Chen¹, Gang Chen², Wei Wang², Han Liu¹, Mukun Ouyang¹, Wanhong Zhang¹, Lianghua Zhang¹, Wei Tang¹, Shilai Hu^2,*

Energy Engineering, Vol.122, No.7, pp. 2819-2843, 2025, DOI:10.32604/ee.2025.065481 - 27 June 2025

Abstract The construction and operation of sulfur-containing gas storage are often more difficult than a non-sulfur storage facility due to the need to prevent environmental contamination from H₂S leaks, as well as the corrosive effects of H₂S on production facilities. Rapid elutriation of H₂S from the reservoir during the construction of the gas storage is an effective way to avoid these problems. However, the existing H₂S elutriation method has low efficiency and high economic cost, which limits the development of reconstructed gas storage of sulfur-containing gas reservoirs. To improve the efficiency of H₂S elutriation in sulfur-containing gas reservoirs and… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.7, pp. 1801-1802, 2025, DOI:10.32604/or.2025.068988 - 26 June 2025

Abstract This article has no abstract. More >

FANGFANG HU¹, ZHIBIN BAI², YANG WANG¹, HAODONG TANG³, JIAHUA ZHOU^1,*

Oncology Research, Vol.33, No.7, pp. 1723-1737, 2025, DOI:10.32604/or.2025.059631 - 26 June 2025

Abstract Background: Kinesin-14 family protein 1 (KIFC1) is abnormally overexpressed in various cancers, and the transcription factor ETS variant 1 (ETV1) is an oncogenic transcription factor in tumors. The potential binding sites on the KIFC1 promoter by ETV1 were observed; however, no evidence supports that ETV1 targets KIFC1. Aims: This study aimed to investigate the relationship between KIFC1 and ETV1, and their effects and mechanisms in pancreatic cancer. Methods: Pan-cancer analysis of KIFC1 expression was performed in GEPIA2 database. KIFC1 expression levels were determined by immunohistochemistry (IHC) in our pancreatic cancer cohort. The correlation between KIFC1… More >