Harika Atmaca1, Gurbuz Gorumlu2, Burcak Karaca2, Mustafa Degirmenci2, Didem Tunali2, Yalcin Cirak2, Duygu Unuvar Purcu1, Selim Uzunoglu1, Bulent Karabulut2, Ulus A. Sanli2, Ruchan Uslu2
European Cytokine Network, Vol.20, No.3, pp. 121-130, 2009, DOI:10.1684/ecn.2009.0159
Abstract In the present study, we aimed to evaluate the possible synergistic, cytotoxic effects of combination
treatment of gossypol and zoledronic acid, in human ovarian cancer cell lines, OVCAR-3 and MDAH-2774, and
to elucidate the role of this novel combination treatment on angiogenesis-related molecules in ovarian cancer.
The XTT cell viability assay was used for showing cytotoxicity. Both DNA fragmentation by ELISA assay and
caspase 3/7 activity measurement were used for demonstrating apoptosis. To elucidate the angiogenic molecules
affected by combination treatment, mRNA levels of angiogenic molecules were measured using the Human
Angiogenesis RT2 ProfilerTM PCR Array… More >
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