Francis X. Keeley Jr

Canadian Journal of Urology, Vol.21, No.1, pp. 7125-7125, 2014

Abstract This article has no abstract. More >

Christine N. Tran¹, Jianbo Li², Daniel A. Shoskes¹

Canadian Journal of Urology, Vol.21, No.2, pp. 7195-7200, 2014

Abstract Introduction: To evaluate the clinical phenotypes of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) using a web based online tool and to compare these clinical features with patients evaluated in a tertiary referral clinic.
Materials and methods: Data was collected from 720 men who gave complete online responses on a website which determines the UPOINT clinical phenotype in CP/CPPS and measures symptom severity with the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). This was compared to phenotype and symptom severity of 220 patients evaluated in person at a tertiary referral clinic.
Results: The web-based cohort… More >

Andrew G. Winer¹, Nicholas H. Chakiryan¹, Ryan P. Mooney¹, Daniel Verges¹, Mazyar Ghanaat¹, Atabak Allaeei², Luke Robinson², Harry Zinn², Erich K. Lang^1,2,3

Canadian Journal of Urology, Vol.21, No.4, pp. 7365-7368, 2014

Abstract Introduction: Pelvic congestion syndrome (PCS) is a complex condition of the pelvic venous system leading to nonspecific pelvic pain that was initially described in females alone. The underlying abnormalities, though diverse, all result in increased pressure in the left gonadal vein which is transmitted retrograde into the pelvic venous system. Our primary aim was to describe our findings of secondary PCS as a distinct entity from primary PCS in that it has an identifiable vascular etiology and is gender nonspecific. We also aimed to assess the adequacy of late-arterial phase CT urography (CTU) as the initial… More >

Leendert W. Schwab, Wouter M. J. Kloosterman, Jakob Konieczny, Katja Loos^*

Journal of Renewable Materials, Vol.1, No.1, pp. 73-78, 2013, DOI:10.7569/JRM.2012.634102

Abstract The papain catalyzed enzymatic synthesis of amido amines catalyzed from aromatic diamines and N-carbobenzyloxy (Z) protected amino acids (Gly, L-Leu, L-Phe) is described. The amides precipitate (yield 19–47 % depending on the amino acid used) from the reaction mixture after one amide bond is formed thus preventing the formation of diamides in all cases. Papain retains its activity in buffers with a higher pH (9 and 12) observable by the amide bond formation between 1,3-phenylene diamine and Z-L-Gly and Z-L-Phe. Aliphatic diamines (1,4-butanediamine and 1,6-hexanediamine) were used as well but amide formation could not be More >

Yongren Wu^∗, Sarah Cisewski^∗, Barton L. Sachs^†, Hai Yao^∗,†,‡

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 159-182, 2013, DOI:10.3970/mcb.2013.010.159

Abstract This study examines the effects of cartilage endplate (CEP) calcification and the injection of intervertebral disc (IVD) cells on the nutrition distributions inside the human IVD under physiological loading conditions using multiphasic finite element modeling. The human disc was modeled as an inhomogeneous mixture consisting of a charged elastic solid, water, ions (Na⁺ and Cl⁻), and nutrient solute(oxygen,glucose and lactate) phases. The effect of the endplate calcification was simulated by a reduction of the tissue porosity (i.e., water volume faction) from 0.60 to 0.48. The effect of cell injection was simulated by increasing the cell density… More >

Dean A. Tripp^1,2,3, J. Curtis Nickel³, Jennifer L. Pikard¹, Laura Katz¹

Canadian Journal of Urology, Vol.19, No.1, pp. 6081-6087, 2012

Abstract Introduction: To estimate the prevalence of chronic prostatitis (CP)-like symptoms in African adolescents, examining the impact of demographic factors, CP-like symptoms (i.e., pain, urinary) and depressive symptoms on quality of life (QoL).
Materials and methods: Community dwelling African males aged 16-19 years (M = 16.97; SD = .88; n = 166), attending secondary school participated. CP-like case identification was based on NIH-Chronic Prostatitis Symptom Index definition (NIH-CPSI; pain in perineum and/or with ejaculation and NIH-CPSI total pain score of ≥ 4 [mild] and ≥ 8 [moderate-severe]). The Patient Health Questionnaire (PHQ) assessed depressive symptoms. CP-like point prevalence… More >

Chad Morley, Aimee Rogers, Stanley Zaslau

Canadian Journal of Urology, Vol.19, No.2, pp. 6160-6164, 2012

Abstract Introduction: Post-vasectomy pain syndrome (PVPS), defined as chronic epididymal pain that is continuous or recurrent in the absence of proven epididymal or testicular infection, has become more common as the number of vasectomies performed rises. With more than four million vasectomies performed annually, the prevention and treatment of this condition becomes more important. Multiple theories have been proposed as a potential etiology of this condition, and along with this have come multiple modalities of treatment. With the uncertainty surrounding the etiology of this syndrome, the aims of treatment are varied and are described and analyzed in… More >

Bruce L. Jacobs¹, Marc C. Smaldone¹, Vikas Tyagi¹, Brian J. Philips¹, Stephen V. Jackman¹, Wendy W. Leng¹, Pradeep Tyagi²

Canadian Journal of Urology, Vol.17, No.1, pp. 4989-4994, 2010

Abstract Objectives: Studies have suggested that pathology of the lower urinary tract can be detected by following changes in urinary proteins. We evaluated urine nerve growth factor (NGF) levels from patients with a variety of urologic conditions to examine NGF's role as a future biomarker.
Materials and methods: Urine samples were obtained from 72 patients with normal non-diseased urinary tracts (n=13), neurogenic overactive bladder (NOAB) (n=13), idiopathic overactive bladder (OAB) (n=17), interstitial cystitis/painful bladder syndrome (IC/PBS) (n=8), prostate cancer (n=7), history of prostate cancer status post robot-assisted laparoscopic prostatectomy (RALP) (n=6), active bladder cancer (n=4), and nephrolithiasis (n=4).… More >

Stephen Lukasewycz¹, Matt Holman², Paul Kozlowski¹, Christopher R. Porter¹, Erin Odom¹, Chris Bernards², Nancy Neil³, John M. Corman¹

Canadian Journal of Urology, Vol.17, No.5, pp. 5377-5382, 2010

Abstract Introduction: Robotic assisted laparoscopic radical prostatectomy (RALP) is a common treatment for localized prostate cancer. Despite a primary advantage of improved postoperative pain, patients undergoing RALP still experience discomfort. Belladonna, containing the muscarinic receptor antagonists atropine and scopolamine, in combination with opium as a rectal suppository (B & O) may improve post-RALP pain. This study evaluates whether a single preoperative B & O results in decreased postoperative patient-reported pain and analgesic requirements.
Materials and methods: Patients undergoing RALP at Virginia Mason Medical Center between November 2008 and July 2009 were offered the opportunity to enter a randomized,… More >

Michael Cox¹, John J. Klutke², Carl G. Klutke¹

Canadian Journal of Urology, Vol.16, No.2, pp. 4536-4540, 2009

Abstract Introduction and objective: Hunner's ulcer subtype interstitial cystitis (IC) is characterized by the presence of circumscribed inflammatory ulcerations in the bladder wall identified during endoscopic examination of individuals with irritative voiding symptoms and pelvic pain. We present our experience with management of this subgroup with intralesional submucosal injection of corticosteroid.
Methods: Prospective analysis of patients presenting with Hunner's ulcer subtype IC was performed between November 2006 and April 2008. All patients underwent flexible cystoscopy and biopsy confirming the presence of Hunner's ulcer(s). Under general anesthesia, 10 ml of triamcinolone acetonide (40 mg/ml) was injected in 0.5 ml… More >