Chad Morley, Aimee Rogers, Stanley Zaslau

Canadian Journal of Urology, Vol.19, No.2, pp. 6160-6164, 2012

Abstract Introduction: Post-vasectomy pain syndrome (PVPS), defined as chronic epididymal pain that is continuous or recurrent in the absence of proven epididymal or testicular infection, has become more common as the number of vasectomies performed rises. With more than four million vasectomies performed annually, the prevention and treatment of this condition becomes more important. Multiple theories have been proposed as a potential etiology of this condition, and along with this have come multiple modalities of treatment. With the uncertainty surrounding the etiology of this syndrome, the aims of treatment are varied and are described and analyzed in… More >

Bruce L. Jacobs¹, Marc C. Smaldone¹, Vikas Tyagi¹, Brian J. Philips¹, Stephen V. Jackman¹, Wendy W. Leng¹, Pradeep Tyagi²

Canadian Journal of Urology, Vol.17, No.1, pp. 4989-4994, 2010

Abstract Objectives: Studies have suggested that pathology of the lower urinary tract can be detected by following changes in urinary proteins. We evaluated urine nerve growth factor (NGF) levels from patients with a variety of urologic conditions to examine NGF's role as a future biomarker.
Materials and methods: Urine samples were obtained from 72 patients with normal non-diseased urinary tracts (n=13), neurogenic overactive bladder (NOAB) (n=13), idiopathic overactive bladder (OAB) (n=17), interstitial cystitis/painful bladder syndrome (IC/PBS) (n=8), prostate cancer (n=7), history of prostate cancer status post robot-assisted laparoscopic prostatectomy (RALP) (n=6), active bladder cancer (n=4), and nephrolithiasis (n=4).… More >

Stephen Lukasewycz¹, Matt Holman², Paul Kozlowski¹, Christopher R. Porter¹, Erin Odom¹, Chris Bernards², Nancy Neil³, John M. Corman¹

Canadian Journal of Urology, Vol.17, No.5, pp. 5377-5382, 2010

Abstract Introduction: Robotic assisted laparoscopic radical prostatectomy (RALP) is a common treatment for localized prostate cancer. Despite a primary advantage of improved postoperative pain, patients undergoing RALP still experience discomfort. Belladonna, containing the muscarinic receptor antagonists atropine and scopolamine, in combination with opium as a rectal suppository (B & O) may improve post-RALP pain. This study evaluates whether a single preoperative B & O results in decreased postoperative patient-reported pain and analgesic requirements.
Materials and methods: Patients undergoing RALP at Virginia Mason Medical Center between November 2008 and July 2009 were offered the opportunity to enter a randomized,… More >

Michael Cox¹, John J. Klutke², Carl G. Klutke¹

Canadian Journal of Urology, Vol.16, No.2, pp. 4536-4540, 2009

Abstract Introduction and objective: Hunner's ulcer subtype interstitial cystitis (IC) is characterized by the presence of circumscribed inflammatory ulcerations in the bladder wall identified during endoscopic examination of individuals with irritative voiding symptoms and pelvic pain. We present our experience with management of this subgroup with intralesional submucosal injection of corticosteroid.
Methods: Prospective analysis of patients presenting with Hunner's ulcer subtype IC was performed between November 2006 and April 2008. All patients underwent flexible cystoscopy and biopsy confirming the presence of Hunner's ulcer(s). Under general anesthesia, 10 ml of triamcinolone acetonide (40 mg/ml) was injected in 0.5 ml… More >

Paul Toren¹, Salima Ladak², Clement Ma^{3, Stuart McCluskey2, Neil Fleshner1}

Canadian Journal of Urology, Vol.16, No.4, pp. 4716-4720, 2009

Abstract Objective: Postoperative analgesia is an important factor influencing surgical outcomes. We aimed to evaluate the role of patient controlled epidural analgesia (PCEA) versus intravenous (IV) patient controlled analgesia (PCA) in patients undergoing radical cystectomy.
Methods: We reviewed data from consecutive patients who had a radical cystectomy at our institution between 2003 and 2007 to evaluate the effect of either PCEA or IV PCA on the patients' postoperative pain--the primary outcome--as well as secondary outcomes including time to begin eating solid food, time to ambulation, and length of hospital stay. The patients received either hydromorphone or morphine via… More >

Stanley Zaslau, Dale R. Riggs, Adam E. Perlmutter, Barbara J. Jackson, Jill Osborne, Stanley J. Kandzari

Canadian Journal of Urology, Vol.15, No.4, pp. 4158-4162, 2008

Abstract Introduction/objective: The degree of sexual dysfunction in patients with painful bladder syndrome (PBS) across their lifespan has not been previously documented.
Material and methods: The Female Sexual Function Index (FSFI) is a research tool to measure the degree of clinical female sexual dysfunction (FSD). This 19-item questionnaire evaluates FSD in six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain. This study used the FSFI with the additional variables of age, geographical location, and current medications. The participants were not blinded to the fact that this study was examining the link between PBS and FSD. Each question in… More >

T. C. Theoharides^1,2,3, D. Kempuraj¹, S. Vakali¹, G. R. Sant⁴

Canadian Journal of Urology, Vol.15, No.6, pp. 4410-4414, 2008

Abstract Objectives: Interstitial cystitis/Painful bladder syndrome (IC/PBS) is a chronic bladder condition of unknown etiology and pathogenesis. However, there is evidence of bladder surface mucosal and glycosaminoglycans (GAG) dysfunction in IC/PBS and GAG replacement therapy has been used to treat the condition. The results of an open label, uncontrolled study of a dietary supplement designed to improve GAG mucopolysaccharides integrity (glucosamine sulfate, sodium hyaluronate and chondroitin sulfate) and reduce bladder wall inflammation (quercetin, rutin) are presented herein.
Methods: Two hundred fifty two IC/PBS patients (25 men, 227 women; 18-69 years old), who had failed other treatments, took four… More >

Lori M. Dulabon¹, Amar Singh¹, Frank Vogel², Alireza Moinzadeh¹

Canadian Journal of Urology, Vol.14, No.3, pp. 3588-3591, 2007

Abstract We report a case of a 19-year-old female who presented with right flank pain and microscopic hematuria.Three years earlier, she sustained a stab wound to the right flank and was managed conservatively. After being diagnosed with an enhancing renal mass using computed tomography (CT) scan, duplex ultrasound and angiography were performed revealing an intrarenal pseudoaneurysm. Endovascular coils were successfully employed to selectively embolize the pseudoaneurysm. More >

Joel M. H. Teichman¹, Robert Moldwin²

Canadian Journal of Urology, Vol.14, No.4, pp. 3599-3607, 2007

Abstract Introduction: Interstitial cystitis (IC) is a potentially severe and debilitating condition of the bladder. Numerous factors have been implicated in its pathogenesis.
Materials and methods: A literature review was conducted on the following topics: urothelium, mucosal lining, interstitial cystitis, bladder, and glycosaminoglycans.
Results: A commonly proposed cause for IC is a defect or alteration in the bladder surface leading to increased permeability to noxious urinary solutes and ultimately to tissue inflammation and neurogenic upregulation. Support for this concept is drawn from studies of the structure, function, and composition of the bladder surface. The cause(s) of this alteration More >

Khurshid A. Guru^1,4, Gregory E. Wilding^3,6, Pamela Piacente¹, Jannah Thompson⁴, Wei Deng⁶, Hyung L. Kim^1,4, James Mohler^1,4, Kathleen O’Leary^2,5

Canadian Journal of Urology, Vol.14, No.6, pp. 3753-3756, 2007

Abstract Introduction: To date, no study has compared postoperative pain and requirement for pain medications in open versus robot-assisted radical cystectomy. Patient reported pain and opiate use were reviewed retrospectively using prospectively collected data from postoperative day one to day of discharge.
Materials and methods: Twenty consecutive robot-assisted radical cystectomy patients were compared to the prior 20 patients who underwent open radical cystectomy. Data was collected prospectively to determine opiate requirements and pain scores in each group. Daily opiate use was converted to morphine sulfate equivalents (MSE) to facilitate comparison. A Likert pain perception scale was used to… More >