QIAO ZHOU^1,2,3, JIAN LIU^2,4, LING XIN⁴, YANYAN FANG^2,4, LEI WAN^2,4, DAN HUANG^2,4, JINCHEN GUO¹, JIANTING WEN^2,4

BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698

Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a More >

LIANHUAN MA¹, SHOUPENG LIU², XIAOWEN ZHEN¹, WEIWEI QIAO¹, LINA MA¹, XIAOMIN ZHANG^3,*

BIOCELL, Vol.46, No.8, pp. 1911-1916, 2022, DOI:10.32604/biocell.2022.019277

Abstract This study was designed to investigate the protective effects of Astaxanthin (AST) in rats with diabetes mellitus (DM) induced by streptozotocin. SD rats were divided into control group (n = 5, only received normal saline), DM group (n = 8) and AST + DM group (n = 8; AST: 50 mg/kg/day). DM rats were induced by intraperitoneal injection of streptozocin (STZ, 65 mg/kg). Blood glucose level and body weight were determined at weeks 0, 2, 4, 6 and 8, respectively. At week 8, kidney function was determined, together with expression of P53 and dynamin-related protein-1 More >

ILGIZ GAREEV¹, OZAL BEYLERLI¹, CHUNLEI WANG^2,3, ANDREI SOKHATSKII^2,3, YANCHAO LIANG^2,3, HUAN XIANG^2,3, CHUNYANG LIU^2,3, XUN XU^2,3, YANG GUANG^2,3

BIOCELL, Vol.46, No.1, pp. 27-35, 2022, DOI:10.32604/biocell.2022.016288

Abstract Brain arteriovenous malformations (AVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment of brain AVMs are some of the urgent problems in neurosurgery. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation. Recent studies have shown that miRNAs can be involved in brain AVMs formation and rupture. There are also extracellular forms of miRNAs. Circulating miRNAs have been detected in the blood circulation and More >

Elio Caruso^*, Silvia Farruggio, Salvatore Agati, Corrado Di Mambro

Congenital Heart Disease, Vol.16, No.4, pp. 309-331, 2021, DOI:10.32604/CHD.2021.015470

Abstract Fetal arrhythmias reach up around 10% of the total third-level perinatal cardiology references. Sustained bradycardia is defined as a baseline fetal heart rate (FHR) of less than 110 bpm sustained for at least 10 min. The overall incidence of malignant fetal bradyarrhythmias, such as complete atrioventricular block (AVB) and channellopathies, is relatively rare, 1:5000 pregnancies, but represents a serious emergency for the gynecologist, neonatologists, and pediatric cardiologists. Fetal complete AVB is strongly associated with maternal connective tissue disease, but it can be also associated with congenital heart disease and usually with a poorer prognosis with More >

Sunil Kumar Sharma¹, Shivam Bhardwaj^2,*, Rashmi Bhardwaj³, Majed Alowaidi¹

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 805-825, 2021, DOI:10.32604/cmc.2020.011937

Abstract This article discusses short–term forecasting of the novel Corona Virus (COVID-19) data for infected and recovered cases using the ARIMA method for Saudi Arabia. The COVID-19 data was obtained from the Worldometer and MOH (Ministry of Health, Saudi Arabia). The data was analyzed for the period from March 2, 2020 (the first case reported) to June 15, 2020. Using ARIMA (2, 1, 0), we obtained the short forecast up to July 02, 2020. Several statistical parameters were tested for the goodness of fit to evaluate the forecasting methods. The results show that ARIMA (2, 1, More >

VIVEK KUMAR, VISHNU AGARWAL^*

BIOCELL, Vol.44, No.4, pp. 461-467, 2020, DOI:10.32604/biocell.2020.011090

Abstract The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December 2019. Also known as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), the disease associated with SARSCoV-2 is even called COVID-19. The infection is said to have originated from the bat community and transmitted to humans through an intermediate host (yet unknown) in Wuhan, in the Hubei region of China. COVID-19 is having a pulverizing impact on the scientific community. As of August 13, 2020, the number of confirmed cases had reached up to 20,439,814 and the death More >

Rakesh Kumar Sinha^1,*, Shiv Shankar Verma², Anshu Rastogi^3,*

Phyton-International Journal of Experimental Botany, Vol.89, No.2, pp. 167-182, 2020, DOI:10.32604/phyton.2020.09359

Abstract Members of the Pathogenesis Related (PR) 10 protein family have been identified in a variety of plant species and a wide range of functions ranging from defense to growth and development has been attributed to them. PR10 protein possesses ribonuclease (RNase) activity, interacts with phytohormones, involved in hormone-mediated signalling, afforded protection against various phytopathogenic fungi, bacteria, and viruses particularly in response to biotic and abiotic stresses. The resistance mechanism of PR10 protein may include activation of defense signalling pathways through possible interacting proteins involved in mediating responses to pathogens, degradation of RNA of the invading… More >

Yuguo YI, Jiamin ZHENG, Yang ZHOU, Zhiqin LIU, Dan WENG^*

BIOCELL, Vol.44, No.1, pp. 7-11, 2020, DOI:10.32604/biocell.2020.08686

Abstract Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world. Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize More >