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  • Open Access

    ARTICLE

    L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways

    HAIYANG CHEN1,2,#, JINGYAO SU1,#, DANYANG CHEN1,#, YUYE DU1, RUILIN ZHENG1, QINGLIN DENG2, QIANQIAN DU3, BING ZHU1,*, YINGHUA LI1,*

    BIOCELL, Vol.46, No.10, pp. 2267-2273, 2022, DOI:10.32604/biocell.2022.020218 - 13 June 2022

    Abstract At present, Hepatocarcinoma is one of the main causes of tumor related death all over the world. However, there are still many clinical restrictions on the treatment of liver cancer. Recently, L-Selenocystine has been shown to be a novel treatment for tumors, especially human glioma cells. But, the mechanism of L-Selenocystine against hepatocellular carcinoma remains unclear. Therefore, the main objective of this study was to investigate the effects of L-Selenocystine on HepG2 cell proliferation and activation of reactive oxygen species (ROS) mediated signaling pathway. L-Selenocystine can significantly inhibit HepG2 cell proliferation by activating caspase-3 and More >

  • Open Access

    ARTICLE

    Pathways to Psychiatry Care among Children with Mental Health Problems

    Hisham A. Ramy, Soheir H. Elghonemy, Nesreen M. Mohsen, Safi M. Nagib*, Mohamed Y. Mohamed

    International Journal of Mental Health Promotion, Vol.24, No.4, pp. 539-550, 2022, DOI:10.32604/ijmhp.2022.020108 - 27 May 2022

    Abstract Many children with mental health problems in Egypt, as in many other countries, do not receive the help they need. Investigating the pathways of care is crucial for the early detection and treatment of these children. This study examined referral patterns and the duration of untreated psychiatric illness of 350 children attending two urban clinical settings in Egypt. Diagnoses were made using the Kiddie Schedule for Affective Disorder and Schizophrenia for School-aged children present and lifetime (K-SADS-PL), Child behavior checklist (CBCL,) and the Stanford-Binet Intelligence Scale. For 46.3%, the most distressing symptom was behavioral problems. More >

  • Open Access

    REVIEW

    Pathways for Sustainable Utilization of Waste Chicken Eggshell

    Omojola Awogbemi1,*, Daramy Vandi Von Kallon1, Victor Sunday Aigbodion2,3

    Journal of Renewable Materials, Vol.10, No.8, pp. 2217-2246, 2022, DOI:10.32604/jrm.2022.019152 - 25 April 2022

    Abstract Chicken eggshell is one of the most common wastes generated from households, restaurants and other food processing outlets. Waste Chicken Eggshells (WCES) also constitutes an environmental nuisance and ends up discarded at dumping site with no consideration of further usage. The main constituent of WCES is calcium carbonate from which calcium or calcium oxide can be extracted for various applications. This current effort reviews recently published literature on the diverse applications of WCES. The considered utilization avenues include catalysts for biofuel production, construction industry, wastewater purification, industrial sector, food industry, medical, and agricultural applications. The… More > Graphic Abstract

    Pathways for Sustainable Utilization of Waste Chicken Eggshell

  • Open Access

    ARTICLE

    An integrated bioinformatics analysis and experimental study identified key biomarkers CD300A or CXCL1, pathways and immune infiltration in diabetic nephropathy mice

    WEI LIANG1,2,*, QIANG LUO1,2,#, ZONGWEI ZHANG1,2,#, KEJU YANG1,2,3, ANKANG YANG1,2, QINGJIA CHI4, HUAN HU5

    BIOCELL, Vol.46, No.8, pp. 1989-2002, 2022, DOI:10.32604/biocell.2022.019300 - 22 April 2022

    Abstract Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It is important to explore the key biomarkers and molecular mechanisms relevant to diabetic nephropathy (DN). We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice. Then we used LIMMA to analyze differentially expressed genes (DEGs) between DN and non-diabetic glomerular samples. And we performed KEGG, gene ontology functional (GO) enrichment, and gene set enrichment analysis to reveal the signaling pathway of the disease. The CIBERSORT algorithm based on support… More >

  • Open Access

    REVIEW

    Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy

    ZIQIAN WANG1,2,#, YAQI LI1,2,#, DONGYANG WANG1,2, YINGQIANG SHEN1,3,4,5,*

    BIOCELL, Vol.46, No.7, pp. 1599-1611, 2022, DOI:10.32604/biocell.2022.018530 - 17 March 2022

    Abstract Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation, Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly, many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic More >

  • Open Access

    REVIEW

    ER exit pathways and the control of proteostasis: Crucial role of the UPR, COPII, and ER-phagy in the secretory pathway

    GIUSEPPINA AMODIO1, VALENTINA PAGLIARA1, PAOLO REMONDELLI1,*, ORNELLA MOLTEDO2

    BIOCELL, Vol.46, No.5, pp. 1131-1137, 2022, DOI:10.32604/biocell.2022.018638 - 06 January 2022

    Abstract The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of More >

  • Open Access

    ARTICLE

    Ang-(1-7) exerts anti-inflammatory and antioxidant activities on high glucose-induced injury by prohibiting NF-κB-IL-1β and activating HO-1 pathways in HUVECs

    FEI CHENG1,#, YIQIAN DING2,#, QING XU3, WEI ZHANG3, YULAN ZHEN4, JING LIU5, SHICHENG LI1, CHANG TU1, GUOHUA LAI1, JUN LAN1,*, JINGFU CHEN1,*

    BIOCELL, Vol.46, No.4, pp. 1053-1066, 2022, DOI:10.32604/biocell.2021.012901 - 15 December 2021

    Abstract Previous reports have suggested that Ang-(1-7) may have a protective effect in endothelial cells against high glucose (HG)-induced cell injury thanks to a modulatory mechanism in the NF-κB signaling pathway. In this study, we have examined whether NF-κB-IL-1β and Heme oxygenase-1 (HO-1) pathways contribute to the protection of Ang-(1-7) against hyperglycemia-induced inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs). Our results indicate that time-varying exposures of HUVECs, from 1 h to 24 h, to high glucose concentrations result in an increased expression of phosphorylated (p)-p65 and HO-1 in a time-dependent manner. As… More >

  • Open Access

    ARTICLE

    Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways

    TIANTIAN XU1,#, RUILIN ZHENG1,#, DANYANG CHEN1,#, HAIYANG CHEN2, MINGQI ZHAO1, MIN GUO1, YI CHEN1, CHANGBING WANG1, LU KUANG1, YINGHUA LI1,*, BING ZHU1,*

    BIOCELL, Vol.46, No.4, pp. 1033-1039, 2022, DOI:10.32604/biocell.2022.017757 - 15 December 2021

    Abstract Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD More >

  • Open Access

    REVIEW

    Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects

    MAURA BENEDETTI, MARIA ELISA GIULIANI, MARICA MEZZELANI, ALESSANDRO NARDI, LUCIA PITTURA, STEFANIA GORBI, FRANCESCO REGOLI

    BIOCELL, Vol.46, No.1, pp. 37-49, 2022, DOI:10.32604/biocell.2022.017507 - 28 September 2021

    Abstract Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this system through connected mechanisms, indirect relationships, and cascade effects from pre-transcriptional to catalytic level, by either enhancing intracellular ROS formation or impairing antioxidant defenses. This review summarizes the current knowledge on the pro-oxidant challenges from emerging environmental stressors threatening marine organisms, such as pharmaceuticals, microplastics and climate-related ocean changes. Emphasis will be placed on oxidative pathways, including signaling proteins and transcription factors involved More >

  • Open Access

    ARTICLE

    Dorsal-Ventral Visual Pathways and Object Characteristics: Beamformer Source Analysis of EEG

    Akanksha Tiwari1, Ram Bilas Pachori1,2, Premjit Khanganba Sanjram1,3,4,*

    CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2347-2363, 2022, DOI:10.32604/cmc.2022.020299 - 27 September 2021

    Abstract In performing a gaming task, mental rotation (MR) is one of the important aspects of visuospatial processing. MR involves dorsal-ventral pathways of the brain. Visual objects/models used in computer-games play a crucial role in gaming experience of the users. The visuospatial characteristics of the objects used in the computer-game influence the engagement of dorsal-ventral visual pathways. The current study investigates how the objects’ visuospatial characteristics (i.e., angular disparity and dimensionality) in an MR-based computer-game influence the cortical activities in dorsal-ventral visual pathways. Both the factors have two levels, angular disparity: convex angle (CA) vs. reflex angle… More >

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