Xinyan Li¹, Xiaoxia Qiu¹, Huan Huang¹, Yili Zhao², Xueqin Li¹, Meng Li¹, Xiaoxian Tian¹

Congenital Heart Disease, Vol.13, No.2, pp. 282-287, 2018, DOI:10.1111/chd.12568

Abstract Objective: To evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous α-thalassemia-1.
Design: Prospective diagnostic study.
Setting: The carrier rate of α-thalassemia-1 (–/αα) in China’s Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, the risk of homozygous a-thalassemia-1 in one pregnancy is 25%.
Patients: Singleton mid-pregnancies at risk of homozygous α-thalassemia-1 were enrolled.
Outcome Measures: Fetal heart measurements, including heart diameter (HD), heart length (HL), heart circumference (HC), and heart area (HA), were measured. The z-scores for these heart parameters were then calculated separately based on previously constructed z-score… More >

Nazih Khater, Mohamed Keheila, Michelle Lightfoot, Jim Shen, Samuel Abourbih, Muhannad Alsyouf, Roger Li, D. Duane Baldwin

Canadian Journal of Urology, Vol.24, No.1, pp. 8634-8640, 2017

Abstract Introduction: Percutaneous nephrolithotomy (PCNL) is associated with significant variability in postoperative pain and subsequent narcotic use. The purpose of this study was to determine the factors associated with high narcotic use following PCNL.
Materials and methods: A single-center retrospective review of patients undergoing initial PCNL between 2004 and 2014 was performed. Preoperative, intraoperative and postoperative factors associated with postoperative narcotic usage were analyzed. The primary outcome variable was mean narcotic usage, standardized to intravenous morphine-equivalents. Patients in the lowest 75th percentile were compared to those in the highest 25th percentile. Univariate and multivariate statistical analyses were performed, with… More >

Shoumiao Li^*†, Baozhong Li^†, Jiaxiang Wang^*, Da Zhang^*, Zhiqiang Liu^†, Zhizhong Zhang^†, Wei Zhang^†, Yunjie Wang^†, Dongxiao Bai^†, Jianyun Guan^†, Yong Zhang^†

Oncology Research, Vol.25, No.1, pp. 93-97, 2017, DOI:10.3727/096504016X14719078133564

Abstract The identification of reliable predictors of chemotherapy sensitivity and early screening of adenocarcinoma of gastroesophageal junction (AGEJ) patients who are resistant to chemotherapy has become an important area of clinical and translational research. We aimed to investigate the predictive value of seven cancerassociated cellular proteins for neoadjuvant chemotherapy in AGEJ patients. Clinical data of 93 patients who received neoadjuvant chemotherapy for locally advanced AGEJ between June 2010 and December 2014 were reviewed. All patients were administered the combination regimen of S-1 and oxaliplatin (SOX). Expression of P-glycoprotein (P-gp), glutathione S-transferase-p (GST-π), topoisomerase II (topo II),… More >

Gautum Agarwal, David Buethe, Christopher Russell, Adam Luchey, Julio M. Pow-Sang

Canadian Journal of Urology, Vol.23, No.2, pp. 8215-8219, 2016

Abstract Introduction: Up to 50% of patients will have disease reclassification while on active surveillance (AS) for their prostate cancer. Determining which patients will have reclassification that will impact their survival is difficult. We investigated clinicopathologic factors associated with disease reclassification and differences in both overall and metastasis free survival between those treated and those remaining on AS.
Materials and methods: We performed a retrospective review of patients who were enrolled in an AS protocol between 1994 and 2000. Inclusion criteria for AS were: < cT2a disease, PSA < 10 ng/mL, < 50% of single core involvement, and… More >

Costas D. Lallas¹, Yomi Fashola¹, Robert B. Den², Francisco Gelpi-Hammerschmidt¹, Anne E. Calvaresi¹, Peter McCue³, Ruth Birbe³, Leonard G. Gomella¹, Edouard J. Trabulsi¹

Canadian Journal of Urology, Vol.21, No.5, pp. 7479-7486, 2014

Abstract Introduction: To identify and assess predictive factors for positive surgical margins (PSM) in patients undergoing radical prostatectomy (RP).
Materials and methods: An Institution Review Board (IRB) approved retrospective review of 1751 patients that underwent RP from March 2000 to June 2013 was performed. Identified were 1740 patients whom had not received neoadjuvant therapy; these were used for the purpose of this analysis. Univariate and multivariate analysis were performed to determine factors associated with and predictive of PSMs, divided into preoperative and pathological. Variables analyzed include age, body mass index (BMI), race, surgeon, surgical modality, pathologic T-stage and… More >

Jay D. Raman^1,3, Benjamin Smith², Jamie Messer¹, Thomas J. Rohner¹, Lewis E. Harpster¹, Carl T. Reese¹

Canadian Journal of Urology, Vol.18, No.5, pp. 5896-5902, 2011

Abstract Introduction: To evaluate preoperative parameters of patients undergoing partial nephrectomy to determine variables that impact selection of operative approach.
Materials and methods: The charts of 229 consecutive patients undergoing partial nephrectomy were reviewed. Clinical data points and associated axial imaging were evaluated to determine factors which contributed to selection of an open (versus laparoscopic) operation.
Results: A total of 140 men and 89 women with a mean age of 57 years, body mass index (BMI) of 31, and glomerular filtration rate (GFR) of 82 mL/min/1.73 m² were included. Twenty-three percent of patients had prior abdominal surgery and 7% had… More >

Daniel J. Lee, Philippa Cheetham, Ketan K. Badani

Canadian Journal of Urology, Vol.17, No.3, pp. 5200-5206, 2010

Abstract Objective: We sought to identify predictors of early urinary continence after robot-assisted prostatectomy (RARP) in men who underwent a posterior rhabdosphincter reconstruction.
Materials and methods: A prospective analysis was performed in 107 consecutive men who underwent RARP by a single surgeon in an academic center. Men were excluded if they received adjuvant radiation therapy (7 men), were lost to follow up (4), or did not have a posterior rhabdosphincter reconstruction (8 men). Eighty-eight men received a posterior rhabdosphincter reconstruction and were followed in this study. Patient demographic and postoperative urinary control was recorded at interval follow up… More >

Manlio A. Goetzl¹, Ron Krebill², Tomas L. Griebling^1,3, J. Brantley Thrasher¹

Canadian Journal of Urology, Vol.16, No.2, pp. 4553-4557, 2009

Abstract Introduction/objective: Margin positivity has been a well described adverse prognostic factor in patients undergoing radical prostatectomy. Previous studies with regards to predictors of margin positivity after prostatectomy have primarily focused on the retropubic or robotic approach. We sought to examine the predictors of margin positivity in a contemporary series of men undergoing radical perineal prostatectomy (RPP).
Materials and methods: We reviewed the records of 103 patients who underwent RPP at our institution from July 1998 until May 2008. A positive surgical margin (PSM) was defined as the presence of cancer cells at the inked margin of the… More >