Susanne Schulz1,2, Undraga Schagdarsurengin1, Thomas Suss1,2, Ursula Müller-Werdan2, Karl Werdan2, Christiane Gläser1
European Cytokine Network, Vol.15, No.2, pp. 105-111, 2004
Abstract Background: Tumor necrosis factor-alpha (TNF-α) has been implicated in the pathogenesis of
numerous complex diseases. The plasma level of this pro-inflammatory cytokine is associated with a variety of
different risk factors, but little is known about the genetic background and the complex interactions. Methods: in
this clinical study, correlations were studied between plasma levels of circulating TNF-α protein (ELISA), its
mRNA expression in monocytes (RT-PCR) and genetic variants of TNF-α gene (SSCP), with several diseases,
including obesity, atherosclerosis, diabetes mellitus, hypertension, as well as risk factors such as age, gender,
inflammatory markers, the coagulation/fibrinolysis balance,… More >
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