YANQIU LI^#,*, CHENJUN HAO^#, WEIYI CHEN, QINGJU MENG

BIOCELL, Vol.46, No.6, pp. 1565-1573, 2022, DOI:10.32604/biocell.2022.018347 - 07 February 2022

Abstract This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus (GDM), the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM. From 2019–2020, 21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital, Panyu District, Guangzhou. The general information such as weight, height, age, body mass index (BMI) before pregnancy were analyzed. Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma… More >

Rachel Gardner¹, Emily Durbak¹, Rachael Baird², Katherine Singh², Jeff Chapa², David Majdalany^3,*

Congenital Heart Disease, Vol.17, No.2, pp. 147-160, 2022, DOI:10.32604/chd.2022.017366 - 26 January 2022

Abstract Background: There is limited literature written on the course and outcomes for pregnant mothers with Shone complex. Methods: We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–2018. Results: Maternal age ranged from 21–39 years. Three patients had preserved left ventricular function while one had moderately decreased function. Gestational age at presentation ranged from 6–15 weeks. There were three successful pregnancies (mean gestational age = 37 weeks, range 35–39 weeks) with one patient accounting for two unsuccessful pregnancies. All infants were delivered via Cesarean section. One More >

JIABAO WU^1,2,#, XIAOHUA LIU^1,2,#, LU HAN^1,2, HUA NIE^1,2, YUAN TANG^1,2, YUNGE TANG^1,3, GE SONG^1,5, LIXIN ZHENG^1,4, WEIBING QIN^1,2,*

BIOCELL, Vol.46, No.4, pp. 1013-1023, 2022, DOI:10.32604/biocell.2022.016744 - 15 December 2021

Abstract Piwi-interacting RNAs (piRNAs) is a novel class of non-coding RNAs. However, changes in piRNA expression profiles in recurrent spontaneous abortion (RSA) have not yet been investigated. The aim of this study was to identify differentially expressed piRNAs in deciduas of RSA patients. Decidua tissues were collected by curettage from recruited RSA patients and normal early pregnant (NEP) women with their informed consent. Small RNA sequencing was used to evaluate the differences in piRNA expression profiles between RSA and NEP. The present results demonstrated that the counts of total piRNA reads in RSA samples were increased… More >

Kentaro Mori^1,*, Kotaro Kitaya², Tomomoto Ishikawa², Yutaka Hata³

Intelligent Automation & Soft Computing, Vol.29, No.2, pp. 335-352, 2021, DOI:10.32604/iasc.2021.01010 - 16 June 2021

Abstract In infertility treatment, it is required to improve a success rate of the treatment. A purpose of this study is to develop a prediction system for pregnancy outcomes using ultrasonic images. In infertility treatment, it is typical to evaluate the endometrial shape by using ultrasonic images. The convolutional neural network (CNN) system developed in the current study predicted pregnancy outcome by velocity information. The velocity information has a movement feature of uterine. It is known that a uterine movement is deep related to infertility. Experiments compared the velocity-based and shape-based systems. The shape-based systems predict… More >

Jadranka Separovic Hanzevacki¹, Marija Brestovac^1,*, Vlatka Reskovic Luksic¹, Blanka Glavas Konja¹, Martina Lovric Bencic¹, Josko Bulum¹, Darko Anic²

Congenital Heart Disease, Vol.16, No.5, pp. 469-475, 2021, DOI:10.32604/CHD.2021.015237 - 03 June 2021

Abstract Patients with complete transposition of the great arteries (TGA) treated by the Senning procedure have a higher risk of developing heart failure due to: a) additional work load of the systemic (morphologic right) ventricle (sRV), b) arrhythmias, mainly caused by surgical implications at the atria as well as c) worsening of systemic tricuspid regurgitation. We present a unique case of a female patient who developed all these complications, who was successfully treated and was able to carry out a twin pregnancy. This breakthrough approach was based on: 1. detecting reversibility potential of myocardial systolic dysfunction… More >

Sara Moufarrij¹, Manisha Gandhi¹, Wilson Lam², Angeline Opina^2,*

Congenital Heart Disease, Vol.16, No.2, pp. 137-139, 2021, DOI:10.32604/CHD.2021.013165 - 26 January 2021

Abstract A 23-year-old female with Tetralogy of Fallot who is 30w6d pregnant presented with palpitations and syncope from an outside hospital. She was found to have ventricular tachycardia. Successful placement of a transvenous implantable cardiac defibrillator allowed for symptomatic control and a subsequent successful vaginal delivery. More >

J.C. Trussell¹, Ava Delu¹, Robert J. Kiltz², Vladimir A. Kuznetsov¹

Canadian Journal of Urology, Vol.27, No.4, pp. 10306-10311, 2020

Abstract Introduction: Men with unexplained infertility (UI) should undergo an initial hormonal evaluation including serum FSH and total testosterone (TT). Unfortunately, there is no consensus regarding which TT cut point should be used to define hypogonadism in such men. To determine the best definition for hypogonadism, three different, literature-based TT cut points were used to assess associations between TT and semen parameters. The hypothesis was that the lowest TT cut point would associate with poorest sperm parameters.
Materials and methods: We performed an IRB-approved retrospective chart review of 247 consecutive males presenting for evaluation of male factor infertility.… More >

Tânia Branco Mano^1,*, João Ferreira Reis¹, Ana Figueiredo Agapito¹, André Monteiro¹, Mário Oliveira¹, Luísa Moura Branco¹, José Fragata², Fátima Pinto³, Rui Cruz Ferreira¹, Lídia de Sousa¹

Congenital Heart Disease, Vol.15, No.3, pp. 153-162, 2020, DOI:10.32604/CHD.2020.011500 - 15 July 2020

Abstract Introduction: Due to the low prevalence and wide variation of severity of Ebstein’s Anomaly (EA), long-term follow-up data are scarce. The aim was to evaluate the long-term outcome of an adult population with EA. Methods: Retrospective analysis of EA adults followed in the past 42 years in a tertiary congenital heart disease outpatient clinic. Predictors of complications and mortality were assessed. Results: We studied 53 patients: 53% females, mean age 46 ± 19 years, 36% cyanotic, 55% diagnosed at adult age. Tricuspid regurgitation was moderate or severe in 33% and 46%, respectively, and during follow-up (mean… More >

Natalie Bottega¹, Isabelle Malhamé², Liming Guo¹, Raluca Ionescu‐Ittu¹, Judith Therrien¹, Ariane Marelli¹

Congenital Heart Disease, Vol.14, No.5, pp. 735-744, 2019, DOI:10.1111/chd.12811

Abstract Background: The number of women with congenital heart disease (CHD) of reproductive age is increasing, yet a description of trends in pregnancy and delivery outcomes in this population is lacking.
Objective: To assess secular trends in pregnancy rates, delivery outcomes, and related health care utilization in the adult female CHD population in Quebec, Canada.
Methods: The Quebec CHD database was used to construct a cohort with all women with CHD aged 18‐45 years between 1992 and 2004. Pregnancy and delivery rates were determined yearly and compared to the general population. Secular trends in pregnancy and delivery rates were… More >

Yuli Y. Kim^1,2, Leah A. Goldberg², Katherine Awh², Tanmay Bhamare^1,2, David Drajpuch², Adi Hirshberg³, Sara L. Partington^1,2, Rachel Rogers⁴, Emily Ruckdeschel^1,2, Lynda Tobin¹, Morgan Venuti², Lisa D. Levine³

Congenital Heart Disease, Vol.14, No.3, pp. 470-478, 2019, DOI:10.1111/chd.12750

Abstract Objective: To assess performance of risk stratification schemes in predicting adverse cardiac outcomes in pregnant women with congenital heart disease (CHD) and to compare these schemes to clinical factors alone.
Design: Single‐center retrospective study.
Setting: Tertiary care academic hospital.
Patients: Women ≥18 years with International Classification of Diseases, Ninth Revision, Clinical Modification codes indicating CHD who delivered between 1998 and 2014. CARPREG I and ZAHARA risk scores and modified World Health Organization (WHO) criteria were applied to each woman.
Outcome Measures: The primary outcome was defined by ≥1 of the following: arrhyth‐ mia, heart failure/pulmonary edema, transient ischemic attack, stroke,… More >