Yang Yang, Yuan-song Bai, Qing Wang

Oncology Research, Vol.25, No.4, pp. 605-615, 2017, DOI:10.3727/096504016X14767450526417

Abstract Recently, increasing evidence has shown that CDGSH iron sulfur domain 2 (CISD2) is involved in the initiation and metastasis of several cancers. However, the evidence of its potential role in pancreatic cancer is still lacking. In our present study, CISD2 was found to be increased in pancreatic cancer samples and multiple cell lines. Moreover, statistical analysis revealed that a high level of CISD2 was related to advanced clinical stage, advanced T-stage, positive vascular invasion, positive distant metastasis, and larger tumor size. In addition, multivariate analysis suggests that CISD2 was an independent prognostic factor in pancreatic… More >

Samaneh Kouzegaran^*, Kourosh Shahraki^†, Ali Makateb^‡, Farkhondeh Shahri^§, Negin Hatami^¶, Vahid Behnod^#, Amir Saber Tanha^**

Oncology Research, Vol.25, No.4, pp. 471-478, 2017, DOI:10.3727/096504016X14721217330657

Abstract In this study, expression of FasL and Ki-67 messenger RNA (FasL and Ki-67 mRNA) in human retinoblastoma (HRB) was examined by the immunohistochemistry method and quantitative real-time PCR. Positive expression of Ki-67 in tumor cells was detected in 16 of 30 patients (53.33%), and only 9 (30%) of the tissues from patients with retinoblastoma showed positive staining for FasL. Our results revealed that FasL expression was significantly higher in tumor tissue with invasion compared with the noninvasion form (p = 0.033). Ki-67 expression was markedly increased in tumor tissues with invasion compared with the noninvasion group… More >

Jay D. Raman

Canadian Journal of Urology, Vol.23, No.1, pp. 8155-8155, 2016

Abstract This article has no abstract. More >

Wassim M. Bazzi¹, Amy L. Tin², Daniel D. Sjoberg², Melanie Bernstein¹, Paul Russo¹

Canadian Journal of Urology, Vol.23, No.1, pp. 8151-8154, 2016

Abstract Introduction: To explore whether the association between preoperative neutrophil-to-lymphocyte ratio (NLR) elevation and worse survival is of use prognostically or merely a reflection of medical comorbidities in clear cell renal cell carcinoma (CC RCC).
Materials and methods: We identified 1970 patients treated at Memorial Sloan Kettering Cancer Center from 1998-2012 by partial or radical nephrectomy for nonmetastatic CC RCC. NLR was calculated by dividing absolute neutrophil count by absolute lymphocyte count; both were obtained from preoperative complete blood count. Uni- and multivariable Cox proportional hazards regression, which included established prognostic variables, were used to test for… More >

Robert M. Turner II¹, Jonathan G. Yabes², Elen Woldemichael¹, Melvin M. Deutsch³, Ryan P. Smith³, Robert S. Werner³, Bruce L. Jacobs¹, Joel B. Nelson¹

Canadian Journal of Urology, Vol.23, No.6, pp. 8568-8575, 2016

Abstract Introduction: Up to 25% of men with prostate cancer who undergo radical prostatectomy will recur. In this setting, salvage radiotherapy may cure patients with local recurrence, but is unable to cure those with occult metastatic disease. The objective of this study is to examine how prostate-specific antigen (PSA) response to radiotherapy predicts subsequent disease progression and survival.
Materials and methods: Using a prospectively populated database of 3089 men who underwent open radical prostatectomy, 212 patients (7%) were identified who received early salvage radiotherapy for biochemical recurrence. The main outcome was time to disease progression after salvage radiotherapy.… More >

Annie Im, Ali Amjad, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Seah Lim, Alison Sehgal, Kathleen A. Dorritie, Robert L. Redner, Brian McLaughlin, Yongli Shuai, Shrina Duggal, Michael Boyiadzis

Oncology Research, Vol.24, No.2, pp. 73-80, 2016, DOI:10.3727/096504016X14586627440156

Abstract Relapsed acute myeloid leukemia (AML) represents a major therapeutic challenge. Achieving complete remission (CR) with salvage chemotherapy is the first goal of therapy for relapsed AML. However, there is no standard salvage chemotherapy. The current study evaluated outcomes and prognostic factors for achievement of CR in 91 AML patients in first relapse who were treated with the mitoxantrone–etoposide combination regimen. The overall response rate (CR and CRi) was 25%. Factors that were associated with a lower rate of CR included older age, shorter duration of first CR, low hemoglobin, and low platelet count. The median… More >

Ahmed M. Mansour¹, Mark S. Soloway², Ahmed Eldefrawy³, Rakesh Singal⁴, Shivam Joshi⁵, Murugesan Manoharan⁵

Canadian Journal of Urology, Vol.22, No.2, pp. 7690-7697, 2015

Abstract Introduction: To evaluate the potential significance of cystoscopy findings following neoadjuvant chemotherapy (NAC) as prognostic indicator in patients undergoing radical cystectomy for muscle-invasive bladder cancer (MIBC).
Materials and methods: Patients who received NAC prior to radical cystectomy for MIBC were analyzed. Patients were divided into two groups according to cystoscopy performed after two cycles of NAC: responders and non-responders. Univariate analysis was performed to analyze associations between observed response to chemotherapy and pT stage, pN stage and tumor downstaging. Logistic regression modeling was fitted to evaluate predictors for extravesical disease and pathologic downstaging. Kaplan-Meier analysis was… More >

Hai-Kun Wang^1,2, Robert Haynes³, Hong-Zhong Huang¹, Leiting Dong^2,4, Satya N. Atluri²

CMES-Computer Modeling in Engineering & Sciences, Vol.105, No.1, pp. 1-24, 2015, DOI:10.3970/cmes.2015.105.001

Abstract In this paper, we propose an approach for diagnostics and prognostics of damaged aircraft structures, by combing high-performance fatigue mechanics with filtering theories. Fast & accurate deterministic analyses of fatigue crack propagations are carried out, by using the Finite Element Alternating Method (FEAM) for computing SIFs, and by using the newly developed Moving Least Squares (MLS) law for computing fatigue crack growth rates. Such algorithms for simulating fatigue crack propagations are embedded in the computer program Safe- Flaw, which is called upon as a subroutine within the probabilistic framework of filter theories. Both the extended… More >

Matthew Hall¹, Allison Polland², Steven Weissbart², Stephen Mock³, Neil Grafstein²

Canadian Journal of Urology, Vol.21, No.4, pp. 7344-7349, 2014

Abstract Introduction: While urinary retention is a known complication of AdVance male sling (AMS) placement for post-prostatectomy incontinence (PPI), there is minimal data regarding ultimate continence outcomes for patients who experience this complication. The purpose of this study was to determine the rate of continence after AMS placement in patients who had postoperative urinary retention as compared with those patients who did not.
Materials and methods: A retrospective review was conducted of patients who underwent AMS placement for PPI between 2008 and 2011 with postoperative void trial (TOV). Preoperative factors such as urodynamic findings, daily pad number (PPD)… More >

Amalia A. Vartanian, Eugenia V. Stepanova, Sergey L. Gutorov, Elico Sh. Solomko, Irina N. Grigorieva, Irina N. Sokolova, Anatoly Yu. Baryshnikov, Mikhail R. Lichinitser

Canadian Journal of Urology, Vol.16, No.4, pp. 4726-4732, 2009

Abstract Background: The ability of aggressive tumors to form nonendothelial tumor cell-lined microvascular channels is known as "vasculogenic mimicry" (VM). VM channels are revealed as periodic acid-Schiff (PAS)-positive patterns, and in some tumors their presence predicts clinical outcomes.
Objective: We aimed to study VM channels in clear cell renal cell carcinoma (cRCC) tumors and explore their prognostic significance and relationship to other suggested prognostic factors such as thymidine phosphorylase (TP) and vascular endothelial growth factor (VEGF) expression.
Methods: We retrospectively studied 45 patients who had undergone radical nephrectomy for clinically confined cRCC (stage T2-T3N0M0) at the Russian Cancer Research… More >