Zohra A. Esaadi¹, Rabab S. Gomaa¹, Beih S. El-Desouky¹, Ehab M. Almetwally², Alia M. Magar^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2063-2097, 2025, DOI:10.32604/cmes.2025.065604 - 31 August 2025

Abstract A new extended distribution called the Odd Exponential Generalized Exponential-Exponential distribution is proposed based on generalization of the odd generalized exponential family (OEGE-E). The statistical properties of the proposed distribution are derived. The study evaluates the accuracy of six estimation methods under complete samples. Estimation techniques include maximum likelihood, ordinary least squares, weighted least squares, maximum product of spacing, Cramer von Mises, and Anderson-Darling methods. Two methods of estimation for the involved parameters are considered based on progressively type II censored data (PTIIC). These methods are maximum likelihood and maximum product of spacing. The proposed More >

Chi Zhang^1,#, Xi Huang^2,#, Cheng Hu¹, Bowen Tang¹, Jianjie Wu¹, Zhuolun Sun¹, Weian Zhu¹, Xiangfu Zhou¹, Hengjun Xiao^1,*, Hua Wang^1,*

Oncology Research, Vol.33, No.9, pp. 2331-2351, 2025, DOI:10.32604/or.2025.065119 - 28 August 2025

Abstract Background: U2AF homology motif kinase 1 (UHMK1) has been associated with RNA processing and protein phosphorylation, thereby influencing tumor progression. The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer (PCa). Methods: In this study, we systematically evaluated the expression and prognostic significance of UHMK1 in public databases, followed by validation through immunohistochemistry (IHC) in PCa specimens. Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo. Additionally, a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1… More >

Hailong Li^1,#, Wen Ouyang^2,#, Yiyin Long¹, Yun Peng¹, Ziyi Liu¹, Qi Zhou¹, Rong Xu^1,*, Wei Du^1,*

Oncology Research, Vol.33, No.9, pp. 2549-2571, 2025, DOI:10.32604/or.2025.065050 - 28 August 2025

Abstract Background: The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer. Methods: Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models. Protein-protein interaction (PPI) networks were constructed by using GeneMANIA. Enrichment analysis is used to explore the signaling pathway regulated by MRPL18. Cell counting kit-8 (CCK-8) assays, colony formation, migration assays, flow cytometry, and xenograft models were employed to evaluate the role of MRPL18 in tumor progression. The immune response of MRPL18 was More >

Meng Cao, Rundong Zhang, Anlan Hong, Shanyuan Ye, Zequn Qiu, Dongqing Li, Tong Lin^*, Yan Wang^*

Oncology Research, Vol.33, No.9, pp. 2507-2527, 2025, DOI:10.32604/or.2025.064780 - 28 August 2025

Abstract Introduction: Acral melanoma (AM) is the predominant subtype of cutaneous melanoma in Asian populations, characterized by more aggressive clinical features and limited neoadjuvant therapy response. Centrosomal protein 55 kDa (CEP55) has been implicated in the pathogenesis of various malignancies, but its role in AM remains undefined. Methods: CEP55 expression in melanoma tissues and cell lines was analyzed by RT-qPCR, Western blotting, and immunohistochemistry (IHC). Databases (GEPIA, Sangerbox, Kaplan-Meier plotter, and TIMER) were used to analyze the expression of CEP55 and its correlation with clinical data of melanoma patients. Functional assays were conducted in vitro and in vivo.… More >

Yuhang Jiang^#, Yijun Xu^#, Qi Zhu, Yingxia Wu, Zhe Wang, Shuang He, Shiyong Yu^*, Honggang Xiang^*

Oncology Research, Vol.33, No.9, pp. 2379-2398, 2025, DOI:10.32604/or.2025.063501 - 28 August 2025

Abstract Background: Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies. Aims: This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Methods: Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified… More >

Yi Zhang¹, Hua Jin^2,*

BIOCELL, Vol.49, No.8, pp. 1529-1543, 2025, DOI:10.32604/biocell.2025.066479 - 29 August 2025

Abstract Objectives: The present study investigated whether Tripartite Motif-Containing Protein 32 (TRIM32) contributes to the aberrant activation of keloid fibroblasts (KFs) via glycolysis. Methods: The expression levels of TRIM32, pyruvate dehydrogenase kinase 1 (PDK1), hexokinase 2 (HK2), and glucose transporter 1 (GLUT1) in normal human skin fibroblasts (NFs) and KFs were analyzed using RT-qPCR analyses and western blotting. Cellular proliferation, invasion, and migration were evaluated using Transwell, wound healing, 5-ethynyl-2^′-deoxyuridine (EdU), and cell counting kit-8 (CCK-8) assays. The extracellular acidification rate (ECAR) was measured using the XF96 Extracellular Flux Analyzer. Glucose uptake and ATP production were measured using… More >

Fan Yang, Zhongbo Zhu, Lijuan Shi, Xiping Liu^*

BIOCELL, Vol.49, No.8, pp. 1413-1433, 2025, DOI:10.32604/biocell.2025.064982 - 29 August 2025

Abstract Gastric cancer remains a leading cause of cancer-related mortality worldwide, with its complex tumor microenvironment (TME) playing a crucial role in tumor initiation, progression, and therapeutic response. As key components of the TME, mesenchymal stem cells (MSCs) influence tumor cell proliferation, invasion, and treatment resistance through cytokine secretion, exosomal communication, and metabolic regulation. MSCs enhance cancer stemness and therapy resistance by modulating glycolysis and fatty acid oxidation (FAO), while also promoting tumor progression through immune modulation and interactions with surrounding microenvironmental elements. Despite their potential for therapeutic applications, the clinical use of MSCs in gastric… More >

Qinghua Qin^*

CMC-Computers, Materials & Continua, Vol.85, No.1, pp. 1-39, 2025, DOI:10.32604/cmc.2025.067293 - 29 August 2025

Abstract Carbon nanotubes (CNTs), black phosphorus nanotubes (BPNTs), and graphene derivatives exhibit significant promise for applications in nano-electromechanical systems (NEMS), energy storage, and sensing technologies due to their exceptional mechanical, electrical, and thermal properties. This review summarizes recent advances in understanding the dynamic behaviors of these nanomaterials, with a particular focus on insights gained from molecular dynamics (MD) simulations. Key areas discussed include the oscillatory and rotational dynamics of double-walled CNTs, fabrication and stability challenges associated with BPNTs, and the emerging potential of graphyne nanotubes (GNTs). The review also outlines design strategies for enhancing nanodevice performance More >

Ling Huang^1,2, Hao Zhang^1,2, Jiwei Mo^1,2, Yuehong Liu^1,2, Qiu Lu^1,2,*, Shuiwang Li^1,2,*

Journal of Information Hiding and Privacy Protection, Vol.7, pp. 45-60, 2025, DOI:10.32604/jihpp.2025.066524 - 31 July 2025

Abstract Rapid advances in computer vision have enabled powerful visual perception systems in areas such as surveillance, autonomous driving, healthcare, and augmented reality. However, these systems often raise serious privacy concerns due to their ability to identify and track individuals without consent. This paper explores the emerging field of identity-hiding visual perception, which aims to protect personal identity within visual data through techniques such as anonymization, obfuscation, and privacy-aware modeling. We provide a system-level overview of current technologies, categorize application scenarios, and analyze major challenges—particularly the trade-off between privacy and utility, technical complexity, and ethical risks. More >

Yuhan Wang, Yimei Meng, Wanqiu Xia, Yusen Liang, Yaru Wang, Peiling Li^*, Lei Fang^*

Oncology Research, Vol.33, No.8, pp. 2141-2159, 2025, DOI:10.32604/or.2025.064367 - 18 July 2025

Abstract Background: Ovarian cancer (OC) is a representative malignancy of the female reproductive system, with a poor prognosis. Long non-coding RNAs (lncRNAs) crucially affect tumor development. This study aimed to identify lncRNAs that potentially participated in OC. Methods: LncRNA expression in cells and tissues was quantified using reverse transcription-quantitative PCR, while fluorescence in situ hybridization determined their cellular localization. Various in vitro assays, together with a mouse xenograft model, were employed to elucidate the function of CYMP antisense RNA 1 (CYMP-AS1) in OC. The molecular mechanisms underlying CYMP-AS1 regulation were investigated through RNA pull-down and immunoprecipitation assays, immunofluorescence… More > Graphic Abstract