Madeleine Collette¹, Géraldine Descamps¹, Catherine Pellat-Deceunynck, Régis Bataille, Martine Amiot

European Cytokine Network, Vol.18, No.3, pp. 1-7, 2007, DOI:10.1684/ecn.2007.0095

Abstract In multiple myeloma, a large number of growth factors (IL-6, IGF-1, FGF, HGF and HB-EGF) are involved in promoting myeloma cell growth. In the present study, a serum-free, cytokine-free, collagen-based assay, which does not allow the generation of spontaneous myeloma colonies, was used to identify the clonogenic growth factors for fourteen myeloma cell lines. IL-6 is the only clonogenic factor able to stimulate both CD45+ and CD45- myeloma cell lines, generating myeloma colonies from 10 out of 14 myeloma cell lines. Using a pharmacological Erk inhibitor, we show that the Erk/MAPK pathway is involved in… More >

VANINA L. JULIANELLI¹ , LILIANA N. GUERRA^*1, JUAN C. CALVO^*1,2

BIOCELL, Vol.31, No.2, pp. 237-245, 2007, DOI:10.32604/biocell.2007.31.237

Abstract Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has being the chosen model for developmental biologist because the most striking changes in morphology and function take place after birth. We have demonstrated a regulation of triglyceride accumulation by protein factors synthesized by normal mouse mammary gland epithelial cells (NMMG), acting on a cell line, 3T3-L1, long used as a model for adipogenesis. In this paper, we demonstrate that this inhibitory effect seems to be shared by other cells of epithelial origin but not by other cell types. We found More >

Guanbin Song^∗,†,‡, Yang Ju^∗,†,§, Hitoshi Soyama^*, Toshiro Ohashi^¶, Masaaki Sato^¶

Molecular & Cellular Biomechanics, Vol.4, No.4, pp. 201-210, 2007, DOI:10.3970/mcb.2007.004.201

Abstract Mechanical stimulation is critical to both physiological and pathological states of living cells. Although a great deal of research has been done on biological and biochemical regulation of the behavior of bone marrow mesenchymal stem cells (MSCs), the influence of biomechanical factors on their behavior is still not fully documented. In this study, we investigated the modulation of mechanical stretch magnitude, frequency, and duration on the human marrow mesenchymal stem cells (hMSCs) proliferation by an in vitro model system using a mechanical stretch loading apparatus, and optimized the stretch regime for the proliferation of hMSCs.… More >

Anat Ratnovsky^∗,†, Matthew Mellema^*, Steven S. An^∗,‡, Jeffrey J. Fredberg^*, Stephanie A. Shore^*

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 143-158, 2007, DOI:10.3970/mcb.2007.004.143

Abstract Obesity is a risk factor for asthma. The purpose of this study was to determine whether metformin, an agent used in the treatment of an obesity-related condition (type II diabetes), might have therapeutic potential for modifying the effects of obesity on airway smooth muscle (ASM) function. Metformin acts via activation of AMP-activated protein kinase (AMPK), a cellular sensor of energy status. In cultured murine ASM cells, metformin (0.2--2 mM) caused a dose-dependent inhibition of cell proliferation induced by PDGF (10^-8 M) and serotonin (10^-4 M). Another AMPK activator, 5-aminoimidazole-4-carboxamide-1-ß-D-riboruranoside (AICAR), also inhibited PDGF-induced proliferation. Furthermore, cells More >

B. Li¹, F. Li¹, H-X. Li¹, X-C. Xu¹, M. Szczodry¹, Z-C. Yang¹, J-S. Lin², J. H-C. Wang^{1, *}

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 225-227, 2006, DOI:10.32604/mcb.2006.003.225

Abstract This article has no abstract. More >

E. K. Moioli¹, B. Shah¹, P. A. Clark¹, M. Stroscio¹, J. J. Mao¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 153-155, 2006, DOI:10.32604/mcb.2006.003.153

Abstract This article has no abstract. More >

Pierre I. Karakiewicz, Paul Perrotte, Mike McCormack, François Peloquin, Jean-Paul Perreault, Philippe Arjane, Hughes Widmer, Fred Saad

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 5-8, 2005

Abstract Introduction: Prostate biopsy strategies have greatly evolved over the past 2 decades.
Methods: We performed a literature review which addressed the initial and repeat biopsy schemes, pathologic risk factors for a positive repeat biopsy, and the ideal timing as well as the number of repeat biopsy sessions.
Results: Extended biopsy schemes (11-13 cores) should be used at initial and repeat biopsy. In the era of extended biopsy schemes, high-grade prostatic intraepithelial neoplasia no longer represents an independent predictor of prostate cancer on repeat biopsy. Conversely, the risk is appreciably increased with atypical small acinar proliferation, and its presence More >