Simon Brewster¹, Levent Türkeri², Maurizio Brausi³, Vincent Ravery⁴, Bob Djavan⁵

Canadian Journal of Urology, Vol.17, No.2, pp. 5071-5076, 2010

Abstract Background: Needle biopsy of the prostate is a common outpatient procedure. In March 2009, the European Association of Urology (EAU) published an updated, evidence-based "Guidelines on Prostate Cancer," including recommendations for this procedure.
Objective: To survey onco-urology specialists attending the 6th European Section of Oncological Urology (ESOU) meeting in Istanbul, Turkey in January 2009, to assess their biopsy practices and compare them with March 2009 EAU guidelines.
Design, setting and participants: The authors designed a questionnaire and distributed it to 606 conference delegates. It was completed by 298 delegates, of whom 156 were experienced onco-urological specialists.
Measurements: The survey… More >

Faina Linkov¹, Yian Gu⁴, Alan A. Arslan^2,3,4, Mengling Liu⁴, Roy E. Shore^2,5, Lyudmila Velikokhatnaya¹, Karen L. Koenig^2,4, Paolo Toniolo³, Adele Marrangoni¹, Zoya Yurkovetsky¹, Anne Zeleniuch-Jacquotte^2,4, Anna E. Lokshin^1,6,7

European Cytokine Network, Vol.20, No.1, pp. 21-26, 2009, DOI:10.1684/ecn.2009.0146

Abstract There is a growing interest in the role that cancer biomarkers, metastasis-related molecules, and chemokines may play in the development and progression of various cancers. However, few studies have addressed the reliability of such biomarkers in healthy individuals over time. The objective of this study was to investigate the temporal reliability of multiple proteins in serum samples from healthy women who donated blood over successive years. Thirty five, postmenopausal women with two, repeated annual visits, and thirty, premenopausal women with three, repeated annual visits were randomly selected among eligible subjects from an existing, prospective cohort.… More >

Kaili Mao¹, Cécile Badoual², Philippe Camparo³, Nicolas Barry Delongchamps¹, Annick Vieillefond⁴, Anh-Tuan Dinh-Xuan⁵, Michaël Peyromaure¹

Canadian Journal of Urology, Vol.15, No.5, pp. 4257-4262, 2008

Abstract Objectives: To study the prognostic value of vascular endothelial growth factor (VEGF)-A and its receptor VEGFR-1 in localized prostate cancer.
Methods: One hundred patients undergoing radical prostatectomy (RP) for clinically localized prostate cancer were prospectively included. Plasma levels of VEGF-A were measured preoperatively. After intervention, tissue microarrays were built from the RP specimens. VEGF-A and VEGFR-1 expressions in prostate cancer tissue were determined using immunochemistry. Then the associations between plasma levels of VEGF-A, VEGF-A and VEGFR-1 expressions in prostate cancer tissue, and the outcome of patients were analyzed.
Results: After a median follow-up of 22 months, 14 patients More >

Pauline T. Truong¹, Eric Berthelet¹, Junella C. Lee¹, Ross Petersen¹, Jan T. W. Lim¹, Catherine A. Gaul², Howard Pai¹, Paul Blood¹, Charles M. Ludgate¹

Canadian Journal of Urology, Vol.13, No.3, pp. 3139-3146, 2006

Abstract Objective: To prospectively evaluate the prevalence and severity of fatigue and its impact on quality of life (QOL) during and after radical external beam radiotherapy (RT) for prostate cancer.
Method and materials: Twenty-eight men with prostate cancer undergoing RT over 6-8 consecutive weeks were prospectively accrued. The Brief Fatigue Inventory (BFI), a validated fatigue assessment tool, was administered at five time points: baseline (week 1), middle of RT (week 3-4), end of RT (last week of RT), and follow-up (median 6.5 weeks after RT). The BFI contained nine questions, each using 0-10 ratings to quantify fatigue severity… More >

Christopher C. Hoag, William N. Taylor, Victor A. Rowley

Canadian Journal of Urology, Vol.13, No.6, pp. 3358-3363, 2006

Abstract Introduction: There is little documentation of the efficacy of the Doli-S lithotripter. This study investigated the outcome of ESWL with the Doli-S lithotripter on previously untreated renal calculi.
Methods: Over a 12-month period, 105 consecutive patients with renal stones, treated by a single urologist were enrolled in the study. None of the stones were previously treated. Data gathered included stone characteristics and treatment characteristics. Treatment was to an endpoint of either fluoroscopically successful fragmentation or to 2500 shockwaves. Patients were followed with KUBs, ultrasounds, or CT-KUBs to assess residual stone burden. Treatment success was defined as… More >

R. Cadossi¹, L. Massari², F. Benazzo³, F. Falez⁴, S. Giannini⁵, C. Zorzi⁶, L. Pederzini⁷, S. Setti¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 239-240, 2006, DOI:10.32604/mcb.2006.003.239

Abstract This article has no abstract. More >

Robert Sabbagh, Michael Mc Cormack, François Péloquin, Raymond Faucher, Jean-Paul Perreault, Paul Perrotte, Pierre I. Karakiewicz, Fred Saad

Canadian Journal of Urology, Vol.11, No.2, pp. 2216-2219, 2004

Abstract Purpose: To compare the incidence of infection between a 1 day and a 3 day antibiotic prophylaxis regimen for transrectal ultrasound (TRUS) guided prostate biopsy in a prospective, randomized open-label trial.
Materials and methods: TRUS examination was performed in the left lateral decubitus position using a Brüel and Kjaer 7 MHz rectal probe. Biopsies were carried out with an 18 gauge Tru-cut needle fired by the hand-held Biopsy gun. An average of eight core biopsies (range 6 to 12) was taken. From May 15, 2000 to May 16, 2001, 363 patients were enrolled in this study. Patients… More >

Les Bowles^1,2, Hanna Bialkowska-Hobrzanska^1,2,3,4, Bernard Bukala⁵, Linda Nott⁵, Hassan Razvi^2,5

Canadian Journal of Urology, Vol.11, No.6, pp. 2438-2444, 2004

Abstract Human telomerase reverse transcriptase (hTERT) mRNA expression has been considered a surrogate marker for telomerase activity based on its parallel detection in urological malignancies, including transitional cell carcinoma (TCC) of the bladder. The objective of this study was to prospectively evaluate the diagnostic performance of urine hTERT mRNA marker and urine cytology in the detection of bladder cancer.
The multiplex hTERT/GAPDH (glyceraldehyde-3- phosphate dehydrogenase) reverse transcription polymerase chain reaction (RT-PCR) assay was employed to assess hTERT mRNA expression in urine sediments from 43 patients with clinically apparent TCC undergoing transurethral resection. Tumor grade and pathological stage… More >

Fred Saad, Robert Sabbagh, Michael McCormack, François Peloquin

Canadian Journal of Urology, Vol.9, No.4, pp. 1592-1594, 2002

Abstract Purpose: To compare patient reported pain during TRUS guided biopsies using intrarectal lidocaine gel versus lubricating gel.
Materials and methods: From May 2000 to May 2001, 360 men undergoing transrectal prostate biopsy were enrolled in this study. Patients were randomized into two groups. In group 1, 180 patients received 10 cc of 2% intrarectal lidocaine gel (Xylocaine® 2% jelly, Astra Pharma Inc.) 5 to 10 minutes before the procedure and in group 2, 180 patients received 10 cc of lubricating gel. No other sedation or analgesia was given. Pain level immediately after the last biopsy was assessed More >

António Tadeu, Andreia Pereira, Luís Godinho¹

CMES-Computer Modeling in Engineering & Sciences, Vol.2, No.1, pp. 49-62, 2001, DOI:10.3970/cmes.2001.002.049

Abstract The Boundary Element Method (BEM) is used to compute the three-dimensional variation pressure field generated by a point pressure source inside a flat waveguide channel filled with a homogeneous fluid, in the presence of infinite rigid circular pipelines. The problem is solved in the frequency domain, using boundary elements to model the pipeline and an appropriate Green's function to simulate the free surface and the rigid floor of the channel. Because of the 2 ---1/2 ---D geometry of the problem, the separation of variables has been used, and the solution at each frequency is expressed in… More >