GUANGXIAN YOU¹, QIAO YANG², XIN LI², LILI CHEN^2,*

Oncology Research, Vol.33, No.4, pp. 905-917, 2025, DOI:10.32604/or.2024.052089 - 19 March 2025

Abstract Background: Lung cancer remains a major factor causing cancer-associated mortality globally. While there have been advancements in treatment options, advanced lung cancer patients still have poor outcomes. This study aims to investigate the potential role of Transmembrane protein 33 (TMEM33) in the development of lung adenocarcinoma. Methods: We leveraged The Cancer Genome Atlas (TCGA) database to analyze the connection between TMEM33 expression to the prognosis of lung adenocarcinoma (LUAD). Cell proliferation, invasiveness, and sphere formation were analyzed by various experiments. The association of miR-214-3p with TMEM33 was explored using luciferase reporter assay, immunoblotting, and real-time… More >

JI-SU HAN¹, HYE-JIN BOO¹, JIN WON HYUN¹, HEESANG SONG², IN-YOUB CHANG³, SANG-PIL YOON^1,4,*

Oncology Research, Vol.33, No.4, pp. 873-884, 2025, DOI:10.32604/or.2024.052003 - 19 March 2025

Abstract Background: Chitosan oligosaccharide (COS) is the major degradation product of chitosan by enzymatic processes. COS, with complete water solubility, exerts significant biological effects, including anti-cancer activity. We investigated the anti-tumor effects of COS on colorectal cancer as effective therapeutic methods with low side effects are lacking. Methods: COS was obtained from low molecular weight chitosan by an enzymatic method and the anti-cancer effects were measured by cell viability assay, flow cytometry analysis, Western blotting, and xenograft. Results: COS suppressed the proliferation of SNU-C5 cells compared to other colorectal cancer cells, but higher concentrations were required in… More > Graphic Abstract

Sahel Abyar^1,2, Shahrzad Shoraka², Seyed Masoud Hosseini², Mohammad Reza Zali³, Seyed Reza Mohebbi^3,*

BIOCELL, Vol.49, No.2, pp. 221-251, 2025, DOI:10.32604/biocell.2025.059787 - 28 February 2025

Abstract Oncogenic viruses include both DNA and RNA viruses which contribute to cancer development by disrupting cellular regulation and interfering in the immune responses. These viruses do not directly cause cancer but instead integrate their genetic material into the host genome thus, affecting cell cycle and tumor suppression. This deregulation also leads to impaired immune function and promotes tumor progression by disrupting the removal of infected cells. Generally, innate immunity consists of two important members, including mitochondria and cell deaths, which impact each other as well. Due to the close correlation between viruses, cell death pathways… More >

SHUANG CHEN^1,2,#, XUEMEI DENG^2,#, XINGTING HE², KEWEI XIANG², GUIHONG CHEN², HONGRU YANG^2,*

Oncology Research, Vol.33, No.3, pp. 687-694, 2025, DOI:10.32604/or.2024.052133 - 28 February 2025

Abstract Background: Previous experiments have demonstrated that hypofractionated radiation therapy (HFRT), low-dose radiation therapy (LDRT), and combined anti-programmed cell death protein 1 (αPD-1) can enhance the abscopal effect. Combined with the phenomenon of low prognosis in patients with breast cancer lung metastasis, our study establishes a mouse model and changes the irradiation regimen of LDRT to explore its preventive effect on breast cancer lung metastasis. Methods: The breast cancer subcutaneous graft tumor model was developed. Two-lung prophylactic LDRT was performed prior to the onset of lung metastases, in combination with HFRT (8 Gy, 3f), and αPD-1… More >

YULIAN WANG¹, LIANLI ZHU¹, RONGHAO ZENG², YUNPING PU³, BAIJIAN CHEN³, YUWEI TAN³, MING HONG^2,*, WEIJIA WANG^1,2,*

Oncology Research, Vol.33, No.3, pp. 695-708, 2025, DOI:10.32604/or.2024.051746 - 28 February 2025

Abstract Background: The role of 1,25-dihydroxyvitamin D3 (1,25-(OH)₂D₃) in cancer prevention and treatment is an emerging topic of interest. However, its effects on the stemness of acute myeloid leukemia (AML) cells are poorly understood. Methods: The proliferation and differentiation of AML cells (HL60 and NB4) were investigated by the CCK-8 assay, immunocytochemical staining, and flow cytometry. The abilities of HL60 and NB4 cells to form spheres were examined by the cell sphere formation assay. In addition, the levels of stemness-associated markers (SOX2, Nanog, OCT4, and c-Myc) in HL60 and NB4 cells were measured by western blotting and… More >

Jinxing Li¹, Mustafa Zor², Xiaojian Zhou³, Guanben Du³, Denis Rodrigue⁴, Xiaodong (Alice) Wang^1,*

Journal of Renewable Materials, Vol.13, No.2, pp. 329-347, 2025, DOI:10.32604/jrm.2024.056795 - 20 February 2025

Abstract In this study, two series of foams based on tannic acid (TA), furfuryl alcohol (FA), soybean protein isolate (SPI), and casein (CA), namely TA–FA–SPI (TS series) and TA–FA–CA (TC series) were developed, and their properties were enhanced by adding poplar fibers (WF). From the samples produced, a complete set of characterization was performed including possible crosslinking reactions, morphology, mechanical properties, flame retardancy, thermal insulation and thermal stability. Fourier-transform infrared spectroscopy (FTIR) revealed possible covalent crosslinking among the components and hydrogen bonding between WF and the matrix. Viscosity results indicated that lower prepolymer viscosity led to… More >

Chenglong Zhong¹, Xianfeng Hou^1,*, Shuai Peng¹, Zhenzhong Gao¹, Qiaofang Zhou¹, Shijing Yan²

Journal of Renewable Materials, Vol.13, No.2, pp. 297-310, 2025, DOI:10.32604/jrm.2024.049534 - 20 February 2025

Abstract The main raw material utilized in wood adhesives comes from petrochemical extractives. However, due to the excessive dependence on petrochemical resources and the adverse impact on the ecosystem and human well-being, there is an increasing trend to develop byproduct protein-based adhesives in the current global food safety context. In this research, flaxseed meal was subjected to pretreatment, and trimethylolpropane triglycidyl ether (TTE) and ethylenediamine (EN) were utilized as crosslinkers to establish a more compact adhesive layer and to prevent water intrusion. The pretreatment decreased the FM/UB viscosity by 60% compared to FM. The combination… More > Graphic Abstract

Hong Lei¹, Xiaojian Zhou², Antonio Pizzi^3,*, Guanben Du^2,*, Xuedong Xi²

Journal of Renewable Materials, Vol.13, No.2, pp. 199-249, 2025, DOI:10.32604/jrm.2025.02024-0048 - 20 February 2025

Abstract This review is composed of three main parts each of which is written by well-known top specialists that have been, in a way or other, also the main participants of the majority of the developments reported. Thus, after a general part covering the grand lines and more in-depth views of more recent tannin, lignin, carbohydrate and soy bioadhesives, some mix of the other bio raw materials with soy protein and soy flour and some other differently sourced bioadhesives for wood, this review presents a more in-depth part on starch-based wood adhesives and a more in-depth… More > Graphic Abstract

Mukul Mishra¹, Deeba Khan², Sehbanul Islam^1,*

BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025

Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

Mengjie Xu, Anbin Wang, Tonghong Zuo, Hecui Zhang, Zhihao Hu, Liquan Zhu^*

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 157-179, 2025, DOI:10.32604/phyton.2025.060566 - 24 January 2025

Abstract Calmodulin-like (CMLs) proteins are critical in calcium signaling and essential for plant growth, development, and stress responses. In many species, the CMLs families have been identified and described. However, the characterization and expression profiling of CMLs genes in tobacco is retrievable. In this study, a comprehensive whole-genome identification and analysis, and 75 NtCML genes were identified in tobacco, each containing two to four EF-hand domains. Most NtCML proteins exhibited conserved gene structures and motifs. Notably, most NtCML proteins were intron-less and distributed across 18 chromosomes. Two pairs of tandemly duplicated genes and seven pairs of segmentally More >