Elena Andreucci^*1, Anna Laurenzana^*, Silvia Peppicelli^*, Alessio Biagioni^*, Francesca Margheri^*, Jessica Ruzzolini^*, Francesca Bianchini^*, Gabriella Fibbi^*, Mario Del Rosso^*†, Chiara Nediani^*, Simona Serratì^‡, Livia Fucci^§, Michele Guida^¶, Lido Calorini^*†1

Oncology Research, Vol.28, No.9, pp. 873-884, 2020, DOI:10.3727/096504021X16273798026651

Abstract Malignant melanoma is a highly aggressive skin cancer characterized by an elevated grade of tumor cell plasticity. Such plasticity allows adaptation of melanoma cells to different hostile conditions and guarantees tumor survival and disease progression, including aggressive features such as drug resistance. Indeed, almost 50% of melanoma rapidly develop resistance to the BRAFV600E inhibitor vemurafenib, with fast tumor dissemination, a devastating consequence for patients’ outcomes. Vasculogenic mimicry (VM), the ability of cancer cells to organize themselves in perfused vascular-like channels, might sustain tumor spread by providing vemurafenibresistant cancer cells with supplementary ways to enter into… More >

Weili Min^*1, Liangzhang Sun^†1, Burong Li^‡, Xiao Gao^*, Shuqun Zhang^*, Yang Zhao^*

Oncology Research, Vol.28, No.9, pp. 857-872, 2020, DOI:10.3727/096504021X16203818567367

Abstract EMT confers increased metastatic potential and the resistance to chemotherapies to cancer cells. However, the precise mechanisms of EMT-related chemotherapy resistance remain unclear. c-Src-mediated caspase 8 phosphorylation essential for EMT in lung adenocarcinoma cell lines preferentially occurs in cells with the mesenchymal phenotype, resulting in chemoresistance to cisplatin plus paclitaxel in patients with resectable lung adenocarcinoma and a significantly worse 5-year PFS. Cisplatin killed lung adenocarcinoma cells regardless of caspase 8. Paclitaxel-triggered necroptosis in lung adenocarcinoma cells was dependent on the phosphorylation or deficiency of caspase 8, during which FADD interacted with RIPK1 to activate More >

Dong Li^*1, Fei-fan Sun^*1, Dan Wang^*1,Tao Wang^*, Jing-jing Peng^*, Jian-Qiong Feng^*, Hua Li^*, Chao Wang^†, Dai-jun Zhou^*, Hong Luo^*, Zeng-qiang Fu^*, Tao Zhang^*

Oncology Research, Vol.28, No.7-8, pp. 827-828, 2020, DOI:10.3727/096504021X16280937554409

Abstract Sorafenib, a multityrosine kinase inhibitor, is a standard treatment for advanced hepatocellular carcinoma (HCC), but the clinical response to sorafenib is seriously limited by drug resistance. Programmed death ligand-1 (PD-L1) is one of the most important inhibitory molecules involved in tumor immune evasion. Recently, it has been reported that PD-L1 could play crucial roles in drug resistance of many kinds of cancers. However, the expression, function, and regulation of PD-L1 in sorafenib-resistant hepatoma cells remain unclear. In this study, we reported that PD-L1 was overexpressed in sorafenib-resistant hepatoma cells, and shRNA-mediated PD-L1 depletion attenuated drug… More >

Xiangbin Tan^*1, Zefei Liao^†1, Shuangyou Zou^*, Liangyun Ma^†, Aimin Wang^*

Oncology Research, Vol.28, No.1, pp. 3-11, 2020, DOI:10.3727/096504019X15509383469698

Abstract Vasohibin2 (VASH2), a proangiogenic factor, has been demonstrated to play an oncogenic role in some common human cancers. However, the detailed function of VASH2 in non-small cell lung cancer (NSCLC) has not previously been studied. In this study, we found that VASH2 was significantly upregulated in NSCLC tissues and cell lines, and its increased expression was associated with NSCLC progression and poor prognosis of patients. Knockdown of VASH2 markedly inhibited cell proliferation and P-glycoprotein expression in NSCLC cells. Overexpression of VASH2 enhanced cell proliferation, P-glycoprotein expression, as well as doxorubicin resistance in NSCLC cells. Moreover,… More >

MEI LAN^#, JINGFENG HU^#, HONGLI YANG, LIQIN ZHANG, XUEZHONG XU, JIANGMING HE^*

BIOCELL, Vol.44, No.4, pp. 751-767, 2020, DOI:10.32604/biocell.2020.012954 - 24 December 2020

Abstract Clubroot of Chinese cabbage (Brassica rapa L. ssp. pekinensis), caused by the obligate parasite Plasmodiophora brassicae, accounts for serious yield losses. The aim of our study was to explore the phytohormone levels and metabolome changes in the roots of resistant and susceptible B. rapa genotypes at a late stage of infection, i.e., 28 days post-infection. Both genotypes showed decreased auxin levels after P. brassicae infection except for indole-3-acetic acid. Overall, the susceptible genotype had higher auxin and cytokinin levels after infection, with the exception of trans-zeatin and 3- indolebutyric acid as compared to the resistant genotype. Jasmonic acid levels declined… More >

Lei Guo^1,2,3, Zi Guan¹, Lixia Guo^1,2,3,*, Weiping Shen¹, Zhilong Xue¹, Pingping Chen¹, Mingru Li¹

Journal of Renewable Materials, Vol.8, No.12, pp. 1711-1727, 2020, DOI:10.32604/jrm.2020.013415 - 12 November 2020

Abstract A recycled aggregate (RA) was prepared by crushing and sieving demolished discarded concrete pavements and was subsequently tested and analyzed to determine its various physical properties. On this basis, pervious concrete (PC) mix proportions were designed. Coarse RA particles with sizes of 5–10 and 10–20 mm were selected. Concrete specimens were prepared with a water–cement ratio of 0.3, an aggregate–cement ratio of 4.5, the substitute rates of RA with 0, 25%, 50%, 75% and a single-/double-gap-graded RA mix (mass ratio of particles with sizes of 5–10 mm to particles with sizes of 10–20 mm: 1:1,… More >

Huiyun Li, Ye Liu, Sumei Chen, Jiafu Jiang, Aiping Song, Weimin Fang, Fadi Chen^*

Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 851-859, 2020, DOI:10.32604/phyton.2020.012361 - 09 November 2020

Abstract Black spot disease, caused by the necrotrophic fungus Alternaria tenuissima (Fr.) Wiltsh (A. tenuissima), is considered a highly destructive disease of Chrysanthemum (Chrysanthemum morifolium Ramat.). A set of 17 accessions of commercial chrysanthemum cultivars were evaluated for resistance to A. tenuissima by seedling artificial inoculation. It was found that the reaction of the accessions to artificial inoculation ranged from resistant to highly susceptible. Five varieties of chrysanthemum (‘Zhongshan Taogui’, ‘Jinba’, ‘Zhongshan Jinguan’, ‘Jinling Wanhuang’ and ‘Jinling Yangguang’) were resistant; two varieties of chrysanthemum (‘Zhongshan Xinggui’ and ‘Zhongshan Jinkui’) were moderately resistant; and others were susceptible to various degrees, four More >

Bin Wang¹, Dayong Li², Yuxin Qin^3,*

Molecular & Cellular Biomechanics, Vol.17, No.4, pp. 179-188, 2020, DOI:10.32604/mcb.2020.011050 - 20 October 2020

Abstract Swimming, as a sport beneficial to body and mind, also has a place in international sports. For swimmers and coaches, it is always the most important to improve the propulsion and reduce the resistance during swimming. This paper briefly introduced the resistance of human body in swimming, described the dynamic resistance of human body in arm stroke, and then introduced the principle of micro disturbance method which was used for measuring the dynamic resistance in swimming. Finally, ten swimmers from school team and ten beginners were tested for the dynamic resistance in freestyle, backstroke and… More >

Yuan Zhang¹, Ping Li¹, Yiqiang Wu^1,2, Guangming Yuan^1,2, Xianjun Li^1,2, Yingfeng Zuo^1,2,*

Journal of Renewable Materials, Vol.8, No.11, pp. 1473-1488, 2020, DOI:10.32604/jrm.2020.011788 - 28 September 2020

Abstract The Chinese fir wood was impregnated using a cyclic increasingpressure method (CIPM) with phenolic prepolymers as the impregnating modifier. Unmodified Chinese fir and progressive increasing-pressure method (PIPM) impregnated Chinese fir were used as reference samples and were compared and analyzed. The product’s chemical structure, internal morphology, crystal structure, and heat resistance were characterized. The transversal and longitudinal sections showed better filling effects, so that it bore greater external loading and reduced the water storage space. CIPM infused more phenolic prepolymer into the Chinese fir. Not only producing more physical filling but also forming more hydrogen More >

SOHEILA HASANIAN¹, NOUR AMIRMOZAFARI², AHMAD FARAJZADEH SHEIKH^3,*, IRAJ MEHREGAN¹

BIOCELL, Vol.44, No.3, pp. 411-419, 2020, DOI:10.32604/biocell.2020.08976 - 22 September 2020

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) strains are the essential cause of infections in communities and hospitals. The present study was conducted to determine the molecular typing of MRSA, isolated from hospitalized patients, using the double-locus sequence typing (DLST). In total, 280 S. aureus isolated from clinical specimens by phenotypic (catalase, coagulase, DNase, oxacillin, vancomycin screening agar and antibiotic disk diffusion), and molecular methods (PCR for determining the mecA, vanA and nuc genes). The DLST and sequencing was performed for MRSA containing mecA. Out of 280 specimens, confirmed as Staphylococcus aureus (S. aureus), 123 (43.9%) strains were MRSA. The highest resistance… More >