Yoichi Arai, Osamu Ogawa

Canadian Journal of Urology, Vol.26, No.2, pp. 9686-9686, 2019

Abstract This article has no abstract. More >

M. VASUMATHI^1,a,*, VELA MURALI^2,b, S. RASHIA BEGUM^1,c, N. RAJENDRAN^2,d

Journal of Polymer Materials, Vol.36, No.1, pp. 1-11, 2019, DOI:10.32381/JPM.2019.36.01.1

Abstract In the Fibre Metal Laminate (FML), Carbon Reinforced Aluminium laminate (CARALL), aluminium is placed next to carbon fibres. The potential difference between the aluminium and carbon is larger, leads to galvanic corrosion, which tries to bring down the durability of the FML. To bring down the effect of corrosion, a material layer is introduced between fibres and aluminium so as to separate them thus lowering the possibility of occurrence of corrosion. Another approach is to coat the surfaces of aluminium with different proportions of aluminium oxide nano particles prior to fabrication of the FML. For More >

Mohammed Yunus^*, Mohammad S. Alsoufi

Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-8, 2019, DOI:10.5098/hmt.12.11

Abstract Swift cooling systems, improved microprocessor chips, processors’ performance and power usage have increased production of an enormous amount of heat and high operating temperatures due to excess heat flux density in the field of microelectronics. A rapid cooling of electronic circuits and heat dissipation for the same size of pipe with the present technology as nano size circuits critically generate high heat flux beyond 100 W/cm2 is currently the challenging task with which we are presented. Cooling in the form of heat transfer should be managed using both thermal conductivity (evaporation) and phase transition (condensation)… More >

Chadwick D. Sevart^* , Theodore L. Bergman

Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-18, 2019, DOI:10.5098/hmt.13.18

Abstract A design approach is proposed and demonstrated to identify desirable two-dimensional solid geometries, cooled by natural convection, that offer superior thermal performance in terms of reduced overall (conduction-convection) thermal resistance. The approach utilizes (i) heat transfer modeling in conjunction with (ii) various novel shape evolution rules. Predictions demonstrate the evolution of the solid shape and associated reduction of the overall thermal resistance. Parametric simulations reveal the dependence of the predicted solid shape on the evolution rule employed, the thermal conductivity of the solid material, and the strength of advection within the fluid. More >

Ming Zhao^* , Yang Tian

Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-10, 2019, DOI:10.5098/hmt.13.4

Abstract The field synergy principle and thermal resistance analysis were carried out for the heat transfer enhancement of a chip heat sink. Thermal analysis of the heat dissipation capacity is applied for setting up the gallery on the rib, changing the fan ventilation diameter, and changing the rib height. The results show that the analysis of field synergy principle agrees well with that of the thermal analysis, and setting up a gallery on the rib can improve the heat capacity of the heat sink. Meanwhile, the results also show that decreasing diameter of the ventilation causes More >

B. Orr^a,* , R. Singh^a, T. L. Phan^a , M. Mochizuki^b

Frontiers in Heat and Mass Transfer, Vol.13, pp. 1-6, 2019, DOI:10.5098/hmt.13.1

Abstract One of the problems with cooling an IGBT inverter chip is that its heat generation is not constant. These chips tend to produce heat in pulses which results in high peak chip temperatures. Transient modelling is required to determine the suitability of a heat sink and to ensure the max peak temperature is not exceeded. This paper demonstrates a method of transient thermal analysis using a thermal resistance / capacitor network. A sample heat sink was modelled and then experimentally tested to validate the model. A novel method of modelling phase change materials (PCM) using More >

Xiaohui Shen, Xia Gao, Hui Li, Yajun Gu, Junguo Wang

Oncology Research, Vol.27, No.1, pp. 73-80, 2019, DOI:10.3727/096504018X15201099883047

Abstract Laryngeal carcinoma is a type of head and neck carcinoma with a high incidence and mortality. Chemotherapy treatments of human laryngeal carcinoma may fail due to the development of chemoresistance. Tissue inhibitor of metalloproteinase 3 (TIMP-3) has been shown to be implicated in a number of pathological processes typical for cancer. The present study aims to investigate the involvement of TIMP-3 in the chemoresistance of laryngeal carcinoma. We showed that TIMP-3 expression was significantly decreased in chemoresistant laryngeal carcinoma tissues compared with chemosensitivity tissues. Patients with low TIMP-3 expression exhibited poorer overall survival than those… More >

Haizhen Wang^*, Zhenghua Tang^*, Ting Li^*, Menglu Liu^*, Yong Li^†, Baoling Xing^*

Oncology Research, Vol.27, No.9, pp. 1051-1060, 2019, DOI:10.3727/096504019X15561873320465

Abstract Medroxyprogesterone (MPA) is used for the conservative treatment of endometrial cancer. Unfortunately, progesterone resistance seriously affects its therapeutic effect. The purpose of the current study was to investigate the influence of deletion of AT-rich interactive domain 1A (ARID1A) in progesterone resistance in Ishikawa cells. Ablation of ARID1A was conducted through the CRISPR/Cas9 technology. Acquired progesterone-resistant Ishikawa (Ishikawa-PR) cells were generated by chronic exposure of Ishikawa cells to MPA. The sensitivity of the parental Ishikawa, Ishikawa-PR, and ARID1A-deficient cells to MPA and/or LY294002 was determined using the Cell Counting Kit-8 (CCK-8) assay and flow cytometry analysis.… More >

Hongbo Sun^*1, Zhifu Zhang^*1, Wei Luo^*, Junmin Liu^*, Ye Lou^†, Shengmei Xia^‡

Oncology Research, Vol.27, No.8, pp. 935-944, 2019, DOI:10.3727/096504019X15555388198071

Abstract Acute lymphoblastic leukemia (ALL) is the most prevalent of pediatric cancers. Neuroepithelial cell-transforming 1 (NET1) has been associated with malignancy in a number of cancers, but the role of NET1 in ALL development is unclear. In the present study, we investigated the effect of NET1 gene in ALL cell proliferation and chemoresistance. We analyzed GEO microarray data comparing bone marrow expression profiles of pediatric B-cell ALL samples and those of age-matched controls. MTT and colony formation assays were performed to analyze cell proliferation. ELISA assays, Western blot analyses, and TUNEL staining were used to detect… More >

Xinwen Wang, Fupeng Zhang, Xi Yang, Meiping Xue, Xiaoli Li, Yu Gao, Likun Liu

Oncology Research, Vol.27, No.8, pp. 871-877, 2019, DOI:10.3727/096504018X15426271404407

Abstract Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), afatinib, has been approved for treating EGFR mutant lung cancer patients, but the mechanism of acquired resistance to afatinib has not been well studied. In this study, we established afatinib acquired resistant cell lines. Gene array technology was used to screen changes in gene expression between afatinib-resistant lung cancer cells and parental cells. Our results showed that secreted phosphoprotein 1 (SPP1) was significantly increased in afatinib-resistant lung cancer cells. To study the effect of SPP1 on afatinib resistance, siSPP1 was used to knock down SSP1 More >