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  • Open Access

    ARTICLE

    Chitosan capped-NLCs enhanced codelivery of gefitinib and simvastatin into MDR HCC: impact of compositions on cell death, JNK3, and Telomerase

    GAMALELDIN I. HARISA1,*, RIYAD F. ALZHRANI1, ABDULRAHMAN A. ALLUHAIDAN1, SULTAN M. ALAMRI1, AHMED H. BAKHEIT2, HANADI H. ASIRI2, SABRY M. ATTIA3

    Oncology Research, Vol.33, No.2, pp. 477-492, 2025, DOI:10.32604/or.2024.053337 - 16 January 2025

    Abstract Background: Hepatocellular carcinoma (HCC) is a health problem due to multi-drug resistance (MDR). Codelivery of multiple oncotherapy in one cargo as chimeric cancer therapy (CCT) is suggested as a solution for MDR. This study aims to engineer chitosan-coated nanostructure lipid carriers (NLCs) loaded with gefitinib (GF) and simvastatin (SV) as CCT for HCC. Methods: Both GF and SV-loaded nanostructure lipids carriers (GFSVNLC) and chitosan-capped GF and SV-loaded nanostructure lipids carriers (CGFSVNLC) formulations were assembled by top-down techniques. Moreover, particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were measured by Zetasizer. The biosafety of… More > Graphic Abstract

    Chitosan capped-NLCs enhanced codelivery of gefitinib and simvastatin into MDR HCC: impact of compositions on cell death, JNK3, and Telomerase

  • Open Access

    ARTICLE

    Circular RNA circAGAP1 promotes sunitinib sensitivity in renal cell carcinoma via sponging multiple PDGFR-targeted miRNAs

    QI LV1,#, GANGMIN WANG2,#, YI HONG1, TIANYI ZHU1, SHUANG QIN1, SAIFEI SUN1, YUTING WANG1, YAOHUA LIU1, QING ZHANG1, CHUNHUI MA3,*, PEIJUN WANG1,*

    Oncology Research, Vol.33, No.2, pp. 407-420, 2025, DOI:10.32604/or.2024.047698 - 16 January 2025

    Abstract Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis. However, the role of circAGAP1 in sunitinib resistance in ccRCC remains unclear. Methods: We used public databases for bioinformatics analysis to identify the binding targets of circAGAP1. Additionally, the effects of circAGAP1 on the proliferation, clonogenesis, apoptosis, and migration of ccRCC cells were… More > Graphic Abstract

    Circular RNA circAGAP1 promotes sunitinib sensitivity in renal cell carcinoma via sponging multiple PDGFR-targeted miRNAs

  • Open Access

    COMMENTARY

    Re: Antibiotic resistance in patients undergoing serial prostate biopsies: risk factors and impact on clinical outcomes

    Cassra B. Clark, Jay D. Raman

    Canadian Journal of Urology, Vol.31, No.1, pp. 11775-11776, 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Antibiotic resistance in patients undergoing serial prostate biopsies: risk factors and impact on clinical outcomes

    Alex J. Xu1, Sameer Thakker2, Vyom Sawhney2, Rozalba Gogaj1, Fjolla Vokshi1, James S. Wysock1

    Canadian Journal of Urology, Vol.31, No.1, pp. 11767-11774, 2024

    Abstract Introduction: We evaluate the rate of developing ciprofloxacin resistance in patients undergoing repeat prostate biopsies (PBx), associated risk factors, and impact on complications.
    Materials and methods: We retrospectively evaluated pre-procedural rectal culture (RCx) data in men undergoing PBx from 1/1/2016 to 1/15/2021. Univariate and multivariate logistic regression were utilized to identify risk factors associated with development of antibiotic resistance. Complication rates were compared between ciprofloxacin-sensitive and ciprofloxacin resistant patients.
    Results: A total of 743 men underwent initial RCx. Initial RCx detected ciprofloxacin resistance in 22% of patients. A history of diabetes (p = 0.01), > 2 prior prostate… More >

  • Open Access

    ARTICLE

    Elicitation of PVY Resistance by Coniothyrium aleuritis

    Mohsen Mohamed Elsharkawy1,*, Mari Sumayli2, Faisal Ay Alzahrani3

    Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3373-3385, 2024, DOI:10.32604/phyton.2024.058875 - 31 December 2024

    Abstract Endophytes associated with plants are recognized as bio-reservoirs of natural products and denote a significant symbiotic interaction in nature. Endophytes penetrate the plant’s interior tissues without showing any indications of disease or obvious alterations. In this study, the potential of a novel and new isolated plant growth-stimulating fungus, Coniothyrium aleuritis, was evaluated against PVY (the pathogen potato virus Y) on potato plants. Many parameters, including disease severity, PVY titer, enzymatic profiling, defense-related biochemical marker (carotenoid), phenolic compounds, proline content, as well as growth and yield parameters, have been investigated to clarify the role of C. aleuritis isolate… More > Graphic Abstract

    Elicitation of PVY Resistance by <i>Coniothyrium aleuritis</i>

  • Open Access

    REVIEW

    Gasotransmitters as Key Members of the Signaling Network Regulating Stomatal Response: Interaction with Other Molecules

    Yuriy E. Kolupaev1,2,*, Tetiana O. Yastreb1,*, Alexander P. Dmitriev3

    Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3151-3195, 2024, DOI:10.32604/phyton.2024.057922 - 31 December 2024

    Abstract Stomatal closure, which serves to limit water loss, represents one of the most rapid and critical reactions of plants, occurring not only in response to drought but also to a range of other stressors, including salinity, extreme temperatures, heavy metals, gaseous toxicants, and pathogen infection. ABA is considered to be the main regulator of stomatal movements in plants under abiotic stress. In the last two decades, however, the list of plant hormones and other physiologically active substances that affect stomatal status has expanded considerably. It is believed that stomata are regulated by a complex multicomponent… More >

  • Open Access

    PROCEEDINGS

    Mechanism of Crack Resistance and Strength-Ductility in Additive Manufacturing of High Entropy Alloys

    Pengda Niu1, Ruidi Li1,*, Tiechui Yuan1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012243

    Abstract In terms of grain refinement and component shape complexity, laser additive manufacturing (AM) is unmatched. This is exemplified by laser powder bed fusion (LPBF), whose rapid solidification and non-equilibrium metallurgy have expanded the understanding of ultra-fine grains and sub-stable organization among academics. At present, the reliability of LPBF components is being questioned by the industry due to the rapid heating and cooling cycles in AM processing, coupled with the extreme non-equilibrium heat-fluid-mass process, which renders LPBF printing vulnerable to metallurgical defects like microcracks and porosity. A significant impediment to the development of LPBF lies in… More >

  • Open Access

    PROCEEDINGS

    Development of a High-Temperature Resistance SLS Sand Mold Process for Titanium Alloy Casting

    Shouyin Zhang1,*, Zhifeng Xu1, Qiangwei Xiao2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012141

    Abstract 3D printing sand mold has been widely used in casting production. However, there exist some problems hindering its application for titanium alloy casting, such as the large amount of gas evolution, cannot withstand high temperature impact, easy to react with titanium alloy melt, etc. This work develops a high-temperature resistance SLS (selective laser sintering) sand mold process by introducing inorganic binder in two different ways, i.e., bi-binder SLS process and SLS infiltration process. After sintering at 1100 ℃, SLS sand mold or core possesses high tensile strength and can be used for titanium alloy casting. More >

  • Open Access

    PROCEEDINGS

    Dynamic Response of Sandwich Panel with Re-Entrant Honeycomb Core Reinforced by Catenary Under Air Blast

    Zhen Zou1,2, Fengxiang Xu1,2,*, Yifan Zhu1,2, Xiaoqiang Niu1,2, Xiao Geng1,2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011093

    Abstract Honeycomb cored sandwich structures have been attracted extensive attentions attributed to outstanding explosion and impact protection capability. Herein, in order to improve the anti-blast performance of re-entrant honeycombs (RH) cored sandwich panel, the conventional RH is reinforced by introducing catenary in the form of connecting both ends of horizontal cell walls and catenary. The results show that the deformation mode of the reinforced RHs (RRH) becomes more stable and regular compared to RHs, and the energy absorption of classic RHs can be enhanced because the reinforced structures and the improved auxetic deformation are employed simultaneously.… More >

  • Open Access

    ARTICLE

    Termite Resistance of Heat-Treated Eucalyptus OSB Bonded with Eco-Friendly Castor Oil Adhesive

    Estefani S. Sugahara1,2,3,*, André M. A. Dias1,3, Fernanda D. Maffioletti5, Juarez B. Paes5, André L. Christoforo4, Edson C. Botelho2, Alfredo M. P. G. Dias1,3, Cristiane I. Campos2

    Journal of Renewable Materials, Vol.12, No.11, pp. 1911-1925, 2024, DOI:10.32604/jrm.2024.056198 - 22 November 2024

    Abstract Over the last decade, the oriented strand board (OSB) market presented meaningful growth. However, as a wood-based product, because of its anatomical structure and chemical composition, OSB can be damaged by biodeterioration agents. Given that, the biodeterioration of OSB panels must be investigated to improve its durability. In this way, this work analyses the biological resistance against termites (Cryptotermes brevis and Nasutitermes corniger) of heat-treated OSB panels made with Eucalyptus wood glued with vegetable-based polyurethane-an eco-friendly and sustainable adhesive derived from castor oil. Various panels were produced with different layers compositions (face:core:face of 25:50:25 and 30:40:30) in wood… More > Graphic Abstract

    Termite Resistance of Heat-Treated Eucalyptus OSB Bonded with Eco-Friendly Castor Oil Adhesive

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