Yizhen Zhang^1,2,#, Juan Li^1,3,#, Huanqing Liu^1,4,#, Hong Xia¹, Jian Su^1,5, Fang Liu¹, Bo Su^6,*, Qi Su^1,*

Oncology Research, Vol.33, No.12, pp. 3869-3886, 2025, DOI:10.32604/or.2025.068689 - 27 November 2025

Abstract Objectives: Gastric cancer (GC) is often associated with high invasiveness, epithelial-mesenchymal transition (EMT), and resistance to 5-fluorouracil (5-FU), highlighting the need for novel therapeutic targets. This study explored whether diallyl disulfide (DADS) upregulates retinoic acid-related orphan receptor alpha (ROR) to weaken the protein kinase C alpha (PKC)/RORα-mediated RORα/β-catenin pathway, thereby inhibiting GC cell invasion, epithelial-mesenchymal transition (EMT), and enhancing 5-FU sensitivity. Methods: Human GC cell lines MGC-803 and SGC7901 were treated with DADS, RORα agonist SR1078/antagonist T0901317, and PKCα agonist TPA/antagonist GO6976. Cell proliferation (MTT), migration (scratch assay), invasion (Transwell), protein expression (Western blot), protein… More >

Huan Wang^1,#, Jindong Xie^1,#, Na Li¹, Qianwen Liu¹, Wenqi Song¹, Wenkuan Chen¹, Cheng Peng^2,*, Hailin Tang^1,*

Oncology Research, Vol.33, No.12, pp. 3789-3800, 2025, DOI:10.32604/or.2025.067592 - 27 November 2025

Abstract Solid tumors comprise the majority of the global cancer burden, with their incidence and associated mortality posing considerable challenges to public health systems. With population growth and aging, the burden of these tumors is anticipated to increase further in the coming decades. The progression of solid tumors depends on dynamic interactions between malignantly transformed cells and the tumor microenvironment (TME). Immune checkpoint inhibitor therapy improves T cell-mediated antitumor activity by suppressing regulatory pathways, such as programmed cell death protein 1/programmed death-ligand 1. Nonetheless, its widespread application is constrained by drug resistance. In this comprehensive review, More >

Ranran Yang^1,2,3,#, Dan Yuan^2,#, Chaohan Liang^4,#, Siying Zhu⁴, Jie Huang², Yingqi Zhang⁴, Weiling He⁵, Qinghai Li^1,*, Hong Zhang^2,*

Oncology Research, Vol.33, No.12, pp. 3945-3971, 2025, DOI:10.32604/or.2025.064463 - 27 November 2025

Abstract Background: Colorectal cancer (CRC) is a predominant contributor to global cancer-associated mortality worldwide. Oxaliplatin (OXP), a foundational chemotherapeutic agent for CRC, often exhibits limited efficacy due to the emergence of drug resistance. Although endothelin-1 (EDN1) has been implicated in tumor drug resistance, its role in oxaliplatin resistance in CRC remains poorly defined. This work aimed to define how EDN1 contributes to oxaliplatin resistance and to explore its potential as a therapeutic target. Methods: Public genomic datasets were analyzed to confirm EDN1 upregulation in colorectal cancer (CRC) and its association with poor prognosis. EDN1 expression was… More >

Mutamba Ropafadzo Peace¹, Thobeka Madide^1,2, Ntethelelo Sibiya^1,*

BIOCELL, Vol.49, No.11, pp. 2069-2091, 2025, DOI:10.32604/biocell.2025.068017 - 24 November 2025

Abstract The pathogenesis of insulin resistance is influenced by environmental factors, genetic predispositions, and several medications. Various drugs used to manage multiple ailments have been shown to induce insulin resistance, which could lead to Type II Diabetes mellitus (T2DM). Central to drug-induced insulin resistance is mitochondrial dysfunction. Amongst disturbed pathways in drug-induced mitochondrial toxicity is mitophagy, a process that removes dysfunctional mitochondria through the lysosomal pathways to maintain mitochondrial quality. A balance must always be maintained between mitochondrial dynamics and mitophagy, as any alterations may contribute to the pathogenesis of metabolic diseases such as diabetes mellitus.… More >

Russel J. Reiter^1,*, Ramaswamy Sharma^2,*, Walter Manucha³, Walter Balduini⁴, Doris Loh⁵, Demetrios A. Spandidos⁶, Alejandro Romero⁷, Vasiliki E. Georgakopoulou⁸, Wei Zhu⁹

BIOCELL, Vol.49, No.11, pp. 2033-2067, 2025, DOI:10.32604/biocell.2025.067661 - 24 November 2025

Abstract The development of cancer cell resistance to conventional treatments continues to be a major obstacle in the successful treatment of tumors of many types. The discovery of a highly efficient direct and indirect free radical scavenger, melatonin, in the mitochondrial matrix may be a factor in determining both the occurrence of cancer cell drug insensitivity as well as radioresistance. This relates to two of the known hallmarks of cancer, i.e., exaggerated free radical generation in the mitochondria and the development of Warburg type metabolism (glycolysis). The hypothesis elaborated in this report assumes that the high… More >

Ilze Irbe^1,*, Laura Andze¹, Inese Filipova^1,2

Journal of Renewable Materials, Vol.13, No.11, pp. 2139-2154, 2025, DOI:10.32604/jrm.2025.02025-0107 - 24 November 2025

Abstract Growing environmental concerns and the need for sustainable alternatives to synthetic materials have led to increased interest in bio-based composites. This study investigates the development and characterization of sustainable egg packaging waste (EPW) biocomposites derived from recycled wood fibers and fungal mycelium filaments as a natural binder. Three formulations were prepared using EPW as the primary substrate, with and without the addition of hemp shives and sawdust as co-substrates. The composites were evaluated for granulometry, density, mechanical strength, hygroscopic behavior, thermal conductivity, and fire performance using cone calorimetry. Biocomposites, composed exclusively of egg packaging waste,… More >

Weixi Zhu^1,2,3, Yongdong Meng^1,3,*, Jindong Xie², Zhenglong Cai^1,3, Yu Lyu², Xiaowei Xu^1,3

Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1733-1744, 2025, DOI:10.32604/sdhm.2025.070098 - 17 November 2025

Abstract To mitigate the severe abrasion damage caused by high-velocity water flow in hydraulic engineering applications in Xizang, China, this study systematically optimized key mix design parameters, including aggregate gradation, sand ratio, fly ash content, and superplasticizer dosage. Based on the optimized mix, the combined effects of an abrasion-resistance enhancement admixture (AEA) and silica fume (SF) on the abrasion resistance of self-compacting concrete (SCC) were examined. The results demonstrated that the appropriate incorporation of AEA and SF significantly improved the abrasion resistance of SCC without compromising its workability. The proposed mix design not only achieves superior… More >

Jingcheng Lyu^1,2,#, Ruiyu Yue^1,2,#, Yichen Zhu^1,2, Ye Tian^1,2,*, Xinyi Hu^1,2,*

Canadian Journal of Urology, Vol.32, No.5, pp. 411-422, 2025, DOI:10.32604/cju.2025.066758 - 30 October 2025

Abstract Objective: Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. Method: A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using t-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary More >

Chao Gui^1,2, Wanying Chang³, Yaping Liu^1,*, Leren Tao³, Daoming Shen¹, Mengyi Ge¹

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1621-1637, 2025, DOI:10.32604/fhmt.2025.072268 - 31 October 2025

Abstract Freeze-drying of structurally heterogeneous biomaterials such as porcine aorta presents considerable modeling challenges due to their inherent multilayer composition and moving sublimation interfaces. Conventional models often overlook structural anisotropy and dynamic boundary progression, while experimental determination of key parameters under cryogenic conditions remains difficult. To address these, this study develops a heat and mass transfer model incorporating a dynamic node strategy for the sublimation interface, which effectively handles continuous computational domain deformation. Additionally, specialized fixed nodes were incorporated to adapt to the multilayer structure and its spatially varying thermophysical properties. A novel non-contact gravimetric system More > Graphic Abstract

Abeer S. Al-Humaimeedy^*

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5207-5236, 2025, DOI:10.32604/cmc.2025.068273 - 23 October 2025

Abstract This paper presents 3RVAV (Three-Round Voting with Advanced Validation), a novel Byzantine Fault Tolerant consensus protocol combining Proof-of-Stake with a multi-phase voting mechanism. The protocol introduces three layers of randomized committee voting with distinct participant roles (Validators, Delegators, and Users), achieving -threshold approval per round through a verifiable random function (VRF)-based selection process. Our security analysis demonstrates 3RVAV provides resistance to Sybil attacks with participants and stake , while maintaining communication complexity. Experimental simulations show 3247 TPS throughput with 4-s finality, representing a 5.8× improvement over Algorand’s committee-based approach. The proposed protocol achieves approximately 4.2-s More >