GAMALELDIN I. HARISA^1,*, RIYAD F. ALZHRANI¹, ABDULRAHMAN A. ALLUHAIDAN¹, SULTAN M. ALAMRI¹, AHMED H. BAKHEIT², HANADI H. ASIRI², SABRY M. ATTIA³

Oncology Research, Vol.33, No.2, pp. 477-492, 2025, DOI:10.32604/or.2024.053337 - 16 January 2025

Abstract Background: Hepatocellular carcinoma (HCC) is a health problem due to multi-drug resistance (MDR). Codelivery of multiple oncotherapy in one cargo as chimeric cancer therapy (CCT) is suggested as a solution for MDR. This study aims to engineer chitosan-coated nanostructure lipid carriers (NLCs) loaded with gefitinib (GF) and simvastatin (SV) as CCT for HCC. Methods: Both GF and SV-loaded nanostructure lipids carriers (GFSVNLC) and chitosan-capped GF and SV-loaded nanostructure lipids carriers (CGFSVNLC) formulations were assembled by top-down techniques. Moreover, particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were measured by Zetasizer. The biosafety of… More > Graphic Abstract

QI LV^1,#, GANGMIN WANG^2,#, YI HONG¹, TIANYI ZHU¹, SHUANG QIN¹, SAIFEI SUN¹, YUTING WANG¹, YAOHUA LIU¹, QING ZHANG¹, CHUNHUI MA^3,*, PEIJUN WANG^1,*

Oncology Research, Vol.33, No.2, pp. 407-420, 2025, DOI:10.32604/or.2024.047698 - 16 January 2025

Abstract Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and developing practical countermeasures for sunitinib resistance in RCC is desirable. In previous studies, we found that circAGAP1 expression was significantly upregulated in clear cell RCC (ccRCC) and was strongly associated with poor prognosis. However, the role of circAGAP1 in sunitinib resistance in ccRCC remains unclear. Methods: We used public databases for bioinformatics analysis to identify the binding targets of circAGAP1. Additionally, the effects of circAGAP1 on the proliferation, clonogenesis, apoptosis, and migration of ccRCC cells were… More > Graphic Abstract

Cassra B. Clark, Jay D. Raman

Canadian Journal of Urology, Vol.31, No.1, pp. 11775-11776, 2024

Abstract This article has no abstract. More >

Alex J. Xu¹, Sameer Thakker², Vyom Sawhney², Rozalba Gogaj¹, Fjolla Vokshi¹, James S. Wysock¹

Canadian Journal of Urology, Vol.31, No.1, pp. 11767-11774, 2024

Abstract Introduction: We evaluate the rate of developing ciprofloxacin resistance in patients undergoing repeat prostate biopsies (PBx), associated risk factors, and impact on complications.
Materials and methods: We retrospectively evaluated pre-procedural rectal culture (RCx) data in men undergoing PBx from 1/1/2016 to 1/15/2021. Univariate and multivariate logistic regression were utilized to identify risk factors associated with development of antibiotic resistance. Complication rates were compared between ciprofloxacin-sensitive and ciprofloxacin resistant patients.
Results: A total of 743 men underwent initial RCx. Initial RCx detected ciprofloxacin resistance in 22% of patients. A history of diabetes (p = 0.01), > 2 prior prostate… More >

Mohsen Mohamed Elsharkawy^1,*, Mari Sumayli², Faisal Ay Alzahrani³

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3373-3385, 2024, DOI:10.32604/phyton.2024.058875 - 31 December 2024

Abstract Endophytes associated with plants are recognized as bio-reservoirs of natural products and denote a significant symbiotic interaction in nature. Endophytes penetrate the plant’s interior tissues without showing any indications of disease or obvious alterations. In this study, the potential of a novel and new isolated plant growth-stimulating fungus, Coniothyrium aleuritis, was evaluated against PVY (the pathogen potato virus Y) on potato plants. Many parameters, including disease severity, PVY titer, enzymatic profiling, defense-related biochemical marker (carotenoid), phenolic compounds, proline content, as well as growth and yield parameters, have been investigated to clarify the role of C. aleuritis isolate… More > Graphic Abstract

Yuriy E. Kolupaev^1,2,*, Tetiana O. Yastreb^1,*, Alexander P. Dmitriev³

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3151-3195, 2024, DOI:10.32604/phyton.2024.057922 - 31 December 2024

Abstract Stomatal closure, which serves to limit water loss, represents one of the most rapid and critical reactions of plants, occurring not only in response to drought but also to a range of other stressors, including salinity, extreme temperatures, heavy metals, gaseous toxicants, and pathogen infection. ABA is considered to be the main regulator of stomatal movements in plants under abiotic stress. In the last two decades, however, the list of plant hormones and other physiologically active substances that affect stomatal status has expanded considerably. It is believed that stomata are regulated by a complex multicomponent… More >

Pengda Niu¹, Ruidi Li^1,*, Tiechui Yuan¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012243

Abstract In terms of grain refinement and component shape complexity, laser additive manufacturing (AM) is unmatched. This is exemplified by laser powder bed fusion (LPBF), whose rapid solidification and non-equilibrium metallurgy have expanded the understanding of ultra-fine grains and sub-stable organization among academics. At present, the reliability of LPBF components is being questioned by the industry due to the rapid heating and cooling cycles in AM processing, coupled with the extreme non-equilibrium heat-fluid-mass process, which renders LPBF printing vulnerable to metallurgical defects like microcracks and porosity. A significant impediment to the development of LPBF lies in… More >

Shouyin Zhang^1,*, Zhifeng Xu¹, Qiangwei Xiao²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.32, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012141

Abstract 3D printing sand mold has been widely used in casting production. However, there exist some problems hindering its application for titanium alloy casting, such as the large amount of gas evolution, cannot withstand high temperature impact, easy to react with titanium alloy melt, etc. This work develops a high-temperature resistance SLS (selective laser sintering) sand mold process by introducing inorganic binder in two different ways, i.e., bi-binder SLS process and SLS infiltration process. After sintering at 1100 ℃, SLS sand mold or core possesses high tensile strength and can be used for titanium alloy casting. More >

Zhen Zou^1,2, Fengxiang Xu^1,2,*, Yifan Zhu^1,2, Xiaoqiang Niu^1,2, Xiao Geng^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011093

Abstract Honeycomb cored sandwich structures have been attracted extensive attentions attributed to outstanding explosion and impact protection capability. Herein, in order to improve the anti-blast performance of re-entrant honeycombs (RH) cored sandwich panel, the conventional RH is reinforced by introducing catenary in the form of connecting both ends of horizontal cell walls and catenary. The results show that the deformation mode of the reinforced RHs (RRH) becomes more stable and regular compared to RHs, and the energy absorption of classic RHs can be enhanced because the reinforced structures and the improved auxetic deformation are employed simultaneously.… More >

Estefani S. Sugahara^1,2,3,*, André M. A. Dias^1,3, Fernanda D. Maffioletti⁵, Juarez B. Paes⁵, André L. Christoforo⁴, Edson C. Botelho², Alfredo M. P. G. Dias^1,3, Cristiane I. Campos²

Journal of Renewable Materials, Vol.12, No.11, pp. 1911-1925, 2024, DOI:10.32604/jrm.2024.056198 - 22 November 2024

Abstract Over the last decade, the oriented strand board (OSB) market presented meaningful growth. However, as a wood-based product, because of its anatomical structure and chemical composition, OSB can be damaged by biodeterioration agents. Given that, the biodeterioration of OSB panels must be investigated to improve its durability. In this way, this work analyses the biological resistance against termites (Cryptotermes brevis and Nasutitermes corniger) of heat-treated OSB panels made with Eucalyptus wood glued with vegetable-based polyurethane-an eco-friendly and sustainable adhesive derived from castor oil. Various panels were produced with different layers compositions (face:core:face of 25:50:25 and 30:40:30) in wood… More > Graphic Abstract