Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (219)
  • Open Access

    ARTICLE

    Long non-coding RNA-ATB induces trastuzumab resistance and aggravates the progression of gastric cancer by repressing miR- 200c via ZNF217 elevation

    JIAZHUANG LI*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

    BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860

    Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions and trastuzumab resistance of… More >

  • Open Access

    HOXB8 contributed to oxaliplatin chemo-resistance in colon cancer cells by activating STAT3

    LIANLI NI1,2,#, YUN YU1,2,#, HAN LIN1,2, WEISHAN ZHUGE2, LU TAO2, YIWEI SHEN2, RI CUI2,*, SHAOTANG LI1,2,*

    BIOCELL, Vol.47, No.10, pp. 2245-2254, 2023, DOI:10.32604/biocell.2023.030147

    Abstract Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC… More >

  • Open Access

    ARTICLE

    Optimization of DC Resistance Divider Up to 1200 kV Using Thermal and Electric Field Analysis

    Dengyun Li, Baiwen Du, Kai Zhu, Jicheng Yu*, Siyuan Liang, Changxi Yue

    Energy Engineering, Vol.120, No.11, pp. 2611-2628, 2023, DOI:10.32604/ee.2023.028282

    Abstract Self-heating and electric field distribution are the primary factors affecting the accuracy of the Ultra High Voltage Direct Current (UHVDC) resistive divider. Reducing the internal temperature rise of the voltage divider caused by self-heating, reducing the maximum electric field strength of the voltage divider, and uniform electric field distribution can effectively improve the UHVDC resistive divider’s accuracy. In this paper, thermal analysis and electric field distribution optimization design of 1200 kV UHVDC resistive divider are carried out: (1) Using the proposed iterative algorithm, the heat dissipation and temperature distribution of the high voltage DC resistive divider are studied, and the… More >

  • Open Access

    ARTICLE

    Ectopic Overexpression of EuCHIT30.7 Improves Nicotiana tabacum Resistance to Powdery Mildew

    Lanjun Li1, Degang Zhao1,2,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 3043-3061, 2023, DOI:10.32604/phyton.2023.031175

    Abstract Various strains of powdery mildew (PM), a notorious plant fungal disease, are prevalent and pose a significant threat to plant health. To control PM, transgenic technology can be used to cultivate more resistant plant varieties. In the present study, we utilized the rapid amplification of cDNA ends (RACE) technique to clone the full-length cDNA sequence of the EuCHIT30.7 gene to explore plant genes with disease resistance functions. Bioinformatics analysis revealed that this gene belongs to the GH18 family and is classified as a class III chitinase. The EuCHIT30.7 gene is expressed throughout the Eucommia ulmoides plant, with the most abundant… More >

  • Open Access

    REVIEW

    A review on re-emerging bacteriophage therapy in the era of XDR

    POOJA BHADORIYA1, RICHA SHARMA1, REKHA MEHROTRA1, SIMRAN KAUR1, ISHA SRIVASTAVA1, MUKUL JAIN2, PRASHANT KAUSHIK3,*

    BIOCELL, Vol.47, No.9, pp. 1915-1930, 2023, DOI:10.32604/biocell.2023.029564

    Abstract In the present medicine world antibiotic resistance is one of the key threats to universal health coverage. Researchers continue to work hard to combat this global health concern. Phage therapy, an age-old practice during the early twentieth century, was outshined by the discovery of antibiotics. With the advent of widespread antibiotic resistance, phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria precisely. Limited side effects, the ability to migrate to different body organs, a distinct mode of action, and proliferation at the infection site, make phages a profitable candidate to replace conventional… More > Graphic Abstract

    A review on re-emerging bacteriophage therapy in the era of XDR

  • Open Access

    ARTICLE

    The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma

    RUI ZHANG1,2,#, PENG ZHOU1,3,#, XIA OU4, PEIZHU ZHAO2, XIJING GUO2, MIAN XI5,*, CHEN QING1,*

    Oncology Research, Vol.31, No.6, pp. 887-897, 2023, DOI:10.32604/or.2023.030184

    Abstract Esophageal squamous cell carcinoma (ESCC) is among the most prevalent causes of cancer-related death in patients worldwide. Resistance to immunotherapy and chemotherapy results in worse survival outcomes in ESCC. It is urgent to explore the underlying molecular mechanism of immune evasion and chemoresistance in ESCC. Here, we conducted RNA-sequencing analysis in ten ESCC tissues from cisplatin-based neoadjuvant chemotherapy patients. We found that DMRTA1 was extremely upregulated in the non-pathologic complete response (non-pCR) group. The proliferation rate of esophageal squamous carcinoma cells was markedly decreased after knockdown of DMRTA1 expression, which could increase cisplatin sensitivity in ESCC. Additionally, suppression of DMRTA1… More >

  • Open Access

    ARTICLE

    Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined in silico and in vitro approach

    MUNEEBA MALIK1, MAMOONA MAQBOOL2, TOOBA NISAR3, TAZEEM AKHTER4, JAVED AHMED UJAN5,6, ALANOOD S. ALGARNI7, FAKHRIA A. AL JOUFI8, SULTAN SHAFI K. ALANAZI9, MOHAMMAD HADI ALMOTARED10, MOUNIR M. SALEM BEKHIT11, MUHAMMAD JAMIL12,*

    Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760

    Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information (NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes retrieved were analyzed… More >

  • Open Access

    ARTICLE

    Development of a High-Temperature Thixotropic Cement Slurry System

    Ping Lv1, Jiufei Liu2, Mengran Xu3,*, Hui Tian3,4, Huajie Liu3, Yuhuan Bu3, Zhuang Cai3, Junfeng Qu5

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.11, pp. 2907-2921, 2023, DOI:10.32604/fdmp.2023.029304

    Abstract Cementing carbonate reservoirs is generally a difficult task. The so-called thixotropic cement slurry has gained considerable attention in this regard as it can help to fix some notable problems. More precisely, it can easily fill the leakage layer; moreover, its gelling strength can grow rapidly when pumping stops, thereby increasing the resistance to gas channeling, effectively preventing this undesired phenomenon in many cases. High-temperature thixotropic cement slurry systems, however, are still in an early stage of development and additional research is needed to make them a viable option. In the present study, using a self-developed composite high-temperature thixotropic additive as… More >

  • Open Access

    ARTICLE

    Evaluation of Pre-Harvest Sprouting (PHS) Resistance and Screening of High-Quality Varieties from Thirty-Seven Quinoa (Chenopodium quinoa Willd.) Resources in Chengdu Plain

    Xin Pan, Ya Gao, Fang Zeng, Chunmei Zheng, Wenxuan Ge, Yan Wan, Yanxia Sun, Xiaoyong Wu*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2921-2936, 2023, DOI:10.32604/phyton.2023.029853

    Abstract Pre-harvest sprouting (PHS) will have a serious effect both on the yield and quality of quinoa (Chenopodium quinoa Willd.). It is crucial to select and breed quinoa varieties with PHS resistance and excellent agronomic traits for guidance production and utilization of quinoa. A comprehensive evaluation of the PHS resistance and agronomic traits of 37 species of quinoa resources was conducted in Chengdu Plain. The evaluation used various methods, including grain germination rate (GR), grain germination index (GI), total spike germination rate (SR), total grain germination index (SI), grey correlation analysis (GCA), cluster analysis and correlation analysis. Results showed significant differences… More >

  • Open Access

    ARTICLE

    Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

    Yuki Kawasaki1,*, Takeshi Sasaki1, Daisuke Kobayashi2

    Congenital Heart Disease, Vol.18, No.4, pp. 431-445, 2023, DOI:10.32604/chd.2023.030910

    Abstract Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized that hemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinical features and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients who underwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI  ≥ 3, SVR index (SVRI) ≥ 20; B, CI < 3, SVRI ≥ 20; C, CI ≥ 3, SVRI < 20; and D, CI < 3, SVRI < 20. The primary outcome was freedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant, and death. Clinical and hemodynamic variables and freedom from… More > Graphic Abstract

    Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

Displaying 21-30 on page 3 of 219. Per Page