Majid Harouni1,*, Vishakha Goyal1, Gabrielle Feldman1, Sam Michael2, Ty C. Voss1
CMC-Computers, Materials & Continua, Vol.85, No.1, pp. 331-366, 2025, DOI:10.32604/cmc.2025.067915
- 29 August 2025
Abstract Semantic segmentation plays a foundational role in biomedical image analysis, providing precise information about cellular, tissue, and organ structures in both biological and medical imaging modalities. Traditional approaches often fail in the face of challenges such as low contrast, morphological variability, and densely packed structures. Recent advancements in deep learning have transformed segmentation capabilities through the integration of fine-scale detail preservation, coarse-scale contextual modeling, and multi-scale feature fusion. This work provides a comprehensive analysis of state-of-the-art deep learning models, including U-Net variants, attention-based frameworks, and Transformer-integrated networks, highlighting innovations that improve accuracy, generalizability, and computational More >