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  • Open Access

    ARTICLE

    Long noncoding RNA TFAP2A-AS1 exerts promotive effects in non-small cell lung cancer progression via controlling the microRNA-548a-3p/CDK4 axis as a competitive endogenous RNA

    YANG ZHANG, LIXIA MA, TINGTING ZHANG, PEIDONG LI, JIABIN XU, ZHUO WANG*

    Oncology Research, Vol.29, No.2, pp. 129-139, 2021, DOI:10.32604/or.2022.03563

    Abstract In this study, we mainly focus on probing expression profile and detailed functions of long non-coding RNA TFAP2A antisense RNA 1 (TFAP2A-AS1) in non-small cell lung cancer (NSCLC). Moreover, the mechanisms played by TFAP2A-AS1 were unraveled comprehensively. Herein, a notable overexpressed TFAP2A-AS1 in NSCLC was observed by TCGA and our own cohort. An increased TFAP2A-AS1 level displayed a negative correlation with the overall survival of patients with NSCLC. Loss-of-function approaches illustrated that the absence of TFAP2A-AS1 weakened NSCLC cell proliferation, colony formation, migration and invasion in vitro. Also, interference of TFAP2A-AS1 caused in vivo tumor growth suppression. Mechanistically, TFAP2A-AS1 could… More >

  • Open Access

    ARTICLE

    The lncRNA FEZF1-AS1 Promotes the Progression of Colorectal Cancer Through Regulating OTX1 and Targeting miR-30a-5p

    Jing Li*†, Lian-mei Zhao, Cong Zhang, Meng Li§, Bo Gao, Xu-hua Hu, Jian Cao, Gui-ying Wang

    Oncology Research, Vol.28, No.1, pp. 51-63, 2020, DOI:10.3727/096504019X15619783964700

    Abstract Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC) progression. Our previous research identified differentially expressed lncRNAs in 10 CRC tissues and 10 matched nontumor tissues by next-generation sequencing (NGS). In this study, we identified an lncRNA, FEZF1 antisense RNA 1 (FEZF1-AS1), and further explored its function and mechanism in CRC. We verified that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Through functional experiments, we found that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion, and proliferation and inhibited tumor growth in vivo. Mechanistically, we discovered that reduced levels… More >

  • Open Access

    RETRACTION

    Retraction notice to “Highly Expressed Antisense Noncoding RNA in the INK4 Locus Promotes Growth and Invasion of Renal Clear Carcinoma Cells via the β-Catenin Pathway” [Oncology Research 25(8) (2017) 1373–1382]

    Qingchun Li*, Yuan Tian, Guangrui Hu, Yun Liang, Wei Bai, Hongjun Li

    Oncology Research, Vol.28, No.9, pp. 973-973, 2020, DOI:10.3727/096504021X16303158875079

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Cache Memory Design for Single Bit Architecture with Different Sense Amplifiers

    Reeya Agrawal1,*, Anjan Kumar1, Salman A. AlQahtani2, Mashael Maashi3, Osamah Ibrahim Khalaf4, Theyazn H. H. Aldhyani5

    CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 2313-2331, 2022, DOI:10.32604/cmc.2022.029019

    Abstract Most modern microprocessors have one or two levels of on-chip caches to make things run faster, but this is not always the case. Most of the time, these caches are made of static random access memory cells. They take up a lot of space on the chip and use a lot of electricity. A lot of the time, low power is more important than several aspects. This is true for phones and tablets. Cache memory design for single bit architecture consists of six transistors static random access memory cell, a circuit of write driver, and sense amplifiers (such as voltage… More >

  • Open Access

    REVIEW

    Papaya Ring Spot Virus: An Understanding of a Severe Positive-Sense Single Stranded RNA Viral Disease and Its Management

    Muhammad Umer1, Mustansar Mubeen2, Yasir Iftikhar2,*, Haider Ali3, Muhammad Zafar-ul-Hye4, Rafia Asghar5, Mazhar Abbas6, Malik Abdul Rehman7, Ernesto A. Moya-Elizondo8, Yuejun He1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2099-2110, 2022, DOI:10.32604/phyton.2022.022013

    Abstract Viral diseases have been studied in-depth for reducing quality, yield, health and longevity of the fruit, to highlight the economic losses. Positive-sense single-stranded RNA viruses are more devastating among all viruses that infect fruit trees. One of the best examples is papaya ringspot virus (PRSV). It belongs to the genus Potyvirus and it is limited to cause diseases on the family Chenopodiaceae, Cucurbitaceae and Caricaceae. This virus has a serious threat to the production of papaya, which is famous for its high nutritional and pharmaceutical values. The plant parts such as leaves, latex, seeds, fruits, bark, peel and roots may… More >

  • Open Access

    ARTICLE

    Sense of Family Coherence in Parents of (Sub) Optimally Developing Children

    Jelena Minić1, Miljana Pavićević2, Ana Stoševski1, Biljana Jaredić1, Dragana Stanojević1, Radoje Šoškić1,*

    International Journal of Mental Health Promotion, Vol.24, No.1, pp. 115-127, 2022, DOI:10.32604/ijmhp.2022.017859

    Abstract The theoretical basis of the paper is Aron Antonovsky’s salutogenetic model of health, which is based on the salutogenic orientation and the sense of coherence understood as the central concept and the most important resource. The primary aim of the study is to determine the strength of the sense of family coherence in parents of optimally developing children and in parents of suboptimally developing children and their correlation with: family satisfaction and family orientation to crisis situations. The study was done using parents (N = 394) sampled from the population of the Republic of Serbia. Questionnaire for Obtaining Basic Data,… More >

  • Open Access

    ARTICLE

    Teensensor: Gaussian Processes for Micro-Blog Based Teen’S Acute and Chronic Stress Detection

    Yuanyuan Xue1,2, Qi Li1, LingFeng1

    Computer Systems Science and Engineering, Vol.34, No.3, pp. 151-164, 2019, DOI:10.32604/csse.2019.34.151

    Abstract Stress is a common problem all over the world. More and more teenagers today have to cope with different stressor events coming from school, family, peer relation, self-cognition, romantic relation, etc. Over-stress without proper guidance will lead to a series of potential problems including physical and mental disorders, and even suicide due to the shortage of teen’ s psychological endurance and controllability. Therefore, it is necessary and important to timely sense adolescents’ stress and help them release the stress properly. In this paper, we present a micro-blog based system called TeenSensor, aiming to detect teens acute and chronic stress from… More >

  • Open Access

    ARTICLE

    A Novel Analytical Technique of the Fractional Bagley-Torvik Equations for Motion of a Rigid Plate in Newtonian Fluids

    Mahmoud H. Taha1, Mohamed A. Ramadan2,*, Dumitru Baleanu3,4,5, Galal M. Moatimid1

    CMES-Computer Modeling in Engineering & Sciences, Vol.124, No.3, pp. 969-983, 2020, DOI:10.32604/cmes.2020.010942

    Abstract The current paper is concerned with a modified Homotopy perturbation technique. This modification allows achieving an exact solution of an initial value problem of the fractional differential equation. The approach is powerful, effective, and promising in analyzing some classes of fractional differential equations for heat conduction problems and other dynamical systems. To crystallize the new approach, some illustrated examples are introduced. More >

  • Open Access

    ARTICLE

    Forest Above Ground Biomass Estimation from Remotely Sensed Imagery in the Mount Tai Area Using the RBF ANN Algorithm

    Liang Wanga,b, Jiping Liua,b, Shenghua Xub, Jinjin Dongc, Yi Yangd

    Intelligent Automation & Soft Computing, Vol.24, No.2, pp. 391-398, 2018, DOI:10.1080/10798587.2017.1296660

    Abstract Forest biomass is a significant indicator for substance accumulation and forest succession, and can provide valuable information for forest management and scientific planning. Accurate estimations of forest biomass at a fine resolution are important for a better understanding of the forest productivity and carbon cycling dynamics. In this study, considering the low efficiency and accuracy of the existing biomass estimation models for remote sensing data, Landsat 8 OLI imagery and field data cooperated with the radial basis function artificial neural network (RBF ANN) approach is used to estimate the forest Above Ground Biomass (AGB) in the Mount Tai area, Shandong… More >

  • Open Access

    ARTICLE

    Teaching pediatric cardiology with meaning and sense

    Joshua A. Daily1,2, Elijah Bolin1,2, Brian K. Eble1,2

    Congenital Heart Disease, Vol.13, No.1, pp. 154-156, 2018, DOI:10.1111/chd.12561

    Abstract Pediatric cardiologists teach complicated concepts to a diverse group of learners that include medical students, nurses, residents, fellows, patients, and parents. Unfortunately, much of what is taught is not retained. In order to increase the likelihood of long-term retention, a cardiologist should teach with both meaning and sense. The authors provide a review of these concepts and give specific examples of how to teach in ways that both make sense and are meaningful to a cardiologist’s leaners. More >

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