J. J. Wentzel^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 7-8, 2019, DOI:10.32604/mcb.2019.05696

Abstract The pathophysiology of atherosclerosis is complex and multifactorial, involving systemic risk factors and biomechanical stimuli. Atherosclerotic plaques predominantly form in regions that are exposed to low shear stress of the blood at the vessel wall, whereas regions of moderate and high shear stress are generally protected. For more than 20 years, my research group performs studies to investigate the role of shear stress in atherosclerotic plaque formation and rupture in coronary and carotid arteries of patients and laboratory animals. For that reason, new technology was developed to 3D reconstruct arteries based on fusion of multiple invasive and non-invasive imaging modalities.… More >

Ying Fang¹, Jianhua Wu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 5-6, 2019, DOI:10.32604/mcb.2019.05695

Abstract For hemostasis and thrombosis, some proteins, such as Von Willebrand Factor (VWF, a multimeric plasma glycoprotein synthesized in endothelial cells and megakaryocytes and secreted to circulation or attached to endothelial cells), the metalloprotease ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13), P-selectin (one of three selectin family members with a N-terminal C-type lectin domain, an epidermal growth factor (EGF)-like module, a series of consensus repeat (CR) units, a transmembrane segment and a short cyto-plasmic domain) and β2 integrin. In adhesion and aggregation of circulating platelets towards to the sites of vascular injury, VWF on vascular… More >

E.J. Sapountzakis¹, V.G. Mokos¹

Structural Durability & Health Monitoring, Vol.2, No.4, pp. 207-224, 2006, DOI:10.3970/sdhm.2006.002.207

Abstract In this paper a boundary element method is developed for the second-order analysis of frames consisting of composite beams of arbitrary constant cross section, taking into account shear deformation effect. The composite beam consists of materials in contact, each of which can surround a finite number of inclusions. The materials have different elasticity and shear moduli with same Poisson's ratio and are firmly bonded together. Each beam is subjected in an arbitrarily concentrated or distributed variable axial loading, while the shear loading is applied at the shear center of the cross section, avoiding in this way the induction of a… More >

FEI XIE^1,2, BAOHONG ZHANG^1,2, WENFENG XU¹, XIAOLING LIAO^1,*, QIUHONG HUANG¹, BO LIU^2,*

BIOCELL, Vol.41, No.2-3, pp. 45-54, 2017, DOI:10.32604/biocell.2017.41.045

Abstract Focal adhesion kinase (FAK) plays a vital role in mediating the adaptability of tumor cells under mechanical stimuli. Previous studies revealed that FAK can locate to different cell compartments, and its regulation is highly dependent on its subcellular localization. However, the local FAK activities and its regulation mechanism in different cell compartments of tumor cells in response to fluid shear stress are still unclear. In this study, 5 dyn/cm² and 20 dyn/cm² of shear stress was applied to HeLa cells for 30 min. The activities of FAK targeting different subcellular compartments (lipids rafts, non-rafts, focal adhesions and cytoplasm) were investigated… More >

H-Q. Chen^1,2, M. Cheng¹, Y. Li¹, J. Wu¹, X-J. Liu²

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 221-221, 2006, DOI:10.32604/mcb.2006.003.221

Abstract This article has no abstract. More >

Alvaro Valencia¹

Molecular & Cellular Biomechanics, Vol.1, No.3, pp. 221-232, 2004, DOI:10.3970/mcb.2004.001.221

Abstract Flow dynamics play an important role in the pathogenesis and treatment of intracranial aneurysms. The evaluation of the velocity field in the aneurysm dome and neck is important for the correct placement of endovascular coils, and the temporal and spatial variations of wall shear stress in the aneurysm are correlated with its growth and rupture. This numerical investigation describes the hemodynamic in two models of terminal aneurysm of the basilar artery. Aneurysm models with a aspect ratio of 1.0 and 1.67 were studied. Each model was subject to physiological representative waveform of inflow for a mean Reynolds number of 560.… More >

Bingbing ZHANG^{1, 2}, Ying ZHANG^{1, 2}, Xiaomei ZHANG^{1, 2}, Yonggang LV^{1, 2}

BIOCELL, Vol.42, No.1, pp. 17-24, 2018, DOI:10.32604/biocell.2018.06115

Abstract Mechanical microenvironment can strongly affect the metastatic efficiency of circulating tumor cells. However, the effect of suspension state on their extravasation and the mechanisms involved are still unclear. To explore the influence of suspension state on extravasation (including adhesion, spreading and transendothelial migration) of breast tumor cells and its relevant molecular mechanism, MDA-MB-231 cells were cultured on poly (2-hydroxyethyl methacrylate) coated 6-well plates to minic the suspension state. Suspension state promoted adhesion, spreading and transendothelial migration of MDA-MB-231 cells to EAhy926 endothelial cells (ECs) monolayer under both the static condition and 0.5 dyne/cm² flow shear stress (FSS). The number of… More >

M. Thiriet¹, S. Naili², C. Ribreau²

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.3&4, pp. 473-488, 2003, DOI:10.3970/cmes.2003.004.473

Abstract The laminar steady flow of incompressible Newtonian fluid is studied in rigid pipes with cross configuration of a collapsed tube to determine both the entry length and the wall shear stress (WSS). The cross section shapes have been defined from the collapse of an infinitely long elastic tube subjected to an uniform transmural pressure. Five characteristic collapsed configurations, from the unstressed down to the point-contact states, with a finite and infinite curvature radius at the contact point, are investigated, although the wall contact is not necessary observed in veins. Such collapsed shapes induce cross gradient in WSS in straight pipes.… More >

B. Liu¹, D. Tang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.2, pp. 55-60, 2011, DOI:10.3970/icces.2011.017.055

Abstract The effects of the non-Newtonian blood viscosity on the wall shear stress (WSS) of the blood flows in stenotic right coronary arteries have been investigated by computer simulations. The numerical calculations were performed using the Newtonian Model and the non-Newtonian models with the fluid obeying the Power Law and the Carreau models for the simulations of unsteady blood flows. The differences on the spatial and temporal WSS distribution patterns due to the different blood properties were compared. The computational results demonstrate that the blood viscosity properties do not affect the spatial WSS distribution pattern qualitatively. The region on the inner… More >

Yang Li¹, Xiuxian Liu², Zhiyong Li^2,*, Jiayi Tong¹, Yi Feng¹, Genshan Ma¹, Chengxing Shen³, Naifeng Liu¹

Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 213-229, 2017, DOI:10.3970/mcb.2017.014.213

Abstract Coronary tortuosity is a common angiographic finding, but the hemodynamic significance of coronary tortuosity is largely unknown. The impact of coronary tortuosity on coronary pressure and wall shear stress is still unclear. We addressed this issue in the present experimental study. A distorted tube model connected to heart pumping machine was established to simulate the coronary circulation. The pressure of each point was measured with a coronary pressure guidewire. Influence of tortuosity angle and tortuosity number on local pressure was measured. Wall shear stress was calculated accordingly to the pressure of each point. Pressure distribution in this system was affected… More >