Cheng Dong^1,2,3, Margaret J. Slattery^2,3, Shile Liang³, Hsin-Hsin Peng²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 145-160, 2005, DOI:10.3970/mcb.2005.002.145

Abstract Attachment of tumor cells to the endothelium (EC) under flow conditions is critical for the migration of tumor cells out of the vascular system to establish metastases. Innate immune system processes can potentially promote tumor progression through inflammation dependant mechanisms.\nobreakspace {} White blood cells, neutrophils (PMN) in particular, are being studied to better understand how the host immune system affects cancer cell adhesion and subsequent migration and metastasis. Melanoma cell interaction with the EC is distinct from PMN-EC adhesion in the circulation. We found PMN increased melanoma cell extravasation, which involved initial PMN tethering on the EC, subsequent PMN capture… More >

Sihan Chen¹, Bao Li¹, Haisheng Yang¹, Jianhang Du², Xiaoling Li², Youjun Liu^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 149-162, 2018, DOI: 10.31614/cmes.2018.04133

Abstract Enhanced external counterpulsation (EECP) is able to treat myocardial ischemia, which is usually caused by coronary artery stenosis. However, the underlying mechanisms regarding why this technique is effective in treating myocardial ischemia remains unclear and there is no patient-specific counterpulsation mode for different rates of coronary artery stenosis in clinic. This study sought to investigate the hemodynamic effect of varied coronary artery stenosis rates when using EECP and the necessity of adopting targeted counterpulsation mode to consider different rates of coronary artery stenosis. Three 3-dimensional (3D) coronary models with different stenosis rates, including 55% (Model 1), 65% (Model 2), and… More >

Yanxia Wang¹, Yu Wang², Siqi Li³, ur Rehman Aziz³, Shutian Liu¹, Kairong Qin^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 127-147, 2018, DOI: 10.31614/cmes.2018.03985

Abstract Assessment of the magnitude and pattern of wall shear stress (WSS) in vivo is the prerequisite for studying the quantitative relationship between exercise-induced WSS and arterial endothelial function. In the previous studies, the calculation of the WSS modulated by exercise training was primarily based upon the rigid tube model, which did not take non-linear effects of vessel elastic deformation into consideration. In this study, with an elastic tube model, we estimated the effect of a bout of 30-minute acute cycling exercise on the WSS and the flow rate in the common carotid artery according to the measured inner diameter, center-line… More >

Anupam Bh,ari¹, Vipin Kumar²

FDMP-Fluid Dynamics & Materials Processing, Vol.10, No.3, pp. 359-375, 2014, DOI:10.3970/fdmp.2014.010.359

Abstract The purpose of this paper is to study the flow characteristics of a ferrofluid revolving through a porous medium with a magnetic-field-dependent viscosity in the presence of a stationary disk. A Finite Difference Method is employed to discretize the set of nonlinear coupled differential equations involved in the problem. The discretized nonlinear equations, in turn, are solved by a Newton method (using MATLAB) taking the initial guess with the help of a PDE Solver. Results displayed in graphical form are used to assess the effect of the variable viscosity and porosity parameters on the velocity components. The displacement thickness of… More >

E.J. Sapountzakis¹, V.G. Mokos²

CMC-Computers, Materials & Continua, Vol.10, No.1, pp. 1-40, 2009, DOI:10.3970/cmc.2009.010.001

Abstract In this paper the boundary element method is employed to develop a displacement solution for the general transverse shear loading problem of composite beams of arbitrary constant cross section. The composite beam (thin or thick walled) consists of materials in contact, each of which can surround a finite number of inclusions. The materials have different elasticity and shear moduli and are firmly bonded together. The analysis of the beam is accomplished with respect to a coordinate system that has its origin at the centroid of the cross section, while its axes are not necessarily the principal bending ones. The transverse… More >