Hichem Guedri^1,*, Abdullah Bajahzar², Hafedh Belmabrouk³

CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.1, pp. 59-77, 2021, DOI:10.32604/cmes.2021.013632 - 30 March 2021

Abstract In recent years, the three dimensional reconstruction of vascular structures in the field of medical research has been extensively developed. Several studies describe the various numerical methods to numerical modeling of vascular structures in near-reality. However, the current approaches remain too expensive in terms of storage capacity. Therefore, it is necessary to find the right balance between the relevance of information and storage space. This article adopts two sets of human retinal blood vessel data in 3D to proceed with data reduction in the first part and then via 3D fractal reconstruction, recreate them in More >

KHAWAR ALI SHAHZAD^1,2,#, ZHONGJIE QIN^3,4,#, YAN LI^1,2,*, DELIN XIA^3,4,*

BIOCELL, Vol.44, No.2, pp. 137-145, 2020, DOI:10.32604/biocell.2020.08500 - 27 May 2020

Abstract Focal adhesions are polyproteins linked to extracellular matrix and cytoskeleton, which play an important role in the process of transforming force signals into intracellular chemical signals and subsequently triggering related physiological or pathological reactions. The cytoskeleton is a network of protein fibers in the cytoplasm, which is composed of microfilaments, microtubules, intermediate filaments, and cross-linked proteins. It is a very important structure for cells to maintain their basic morphology. This review summarizes the process of fluid shear stress transduction mediated by focal adhesion and the key role of the cytoskeleton in this process, which focuses More >

Chen Yu¹, Qifu Wang^{1, ∗}, Chao Mei¹, Zhaohui Xia¹

CMES-Computer Modeling in Engineering & Sciences, Vol.122, No.3, pp. 779-803, 2020, DOI:10.32604/cmes.2020.09363 - 01 March 2020

Abstract This paper proposes a multiscale isogeometric topology optimization (ITO) method where the configuration and layout of microstructures are optimized simultaneously. At micro scale, a shape deformation method is presented to transform a prototype microstructure (PM) for obtaining a series of graded microstructures (GMs), where microstructural skeleton based on the level set framework is applied to retain more topology features and improve the connectability. For the macro scale calculation, the effective mechanical properties can be estimated by means of the numerical homogenization method. By adopting identical non-uniform rational basis splines (NURBS) as basis functions for both More >

Yang Song¹, Jennifer Soto¹, Song Li^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 92-92, 2019, DOI:10.32604/mcb.2019.07345

Abstract Cell reprograming technologies have broad applications in cell therapy, disease modeling and drug screening. Direct reprogramming of fibroblasts into induced neuronal (iN) cells has been achieved via the forced expression of three transcription factors: Ascl1, Brn2 and Myt1l. Accumulative evidence suggests that biophysical factors in the microenvironment can regulate the epigenetic state and cell reprogramming. However, whether intracellular mechanical properties regulate cell reprogramming remains unknown. Here, we show for the first time, that the mechanical property of cells is modulated during the early phase of reprogramming as determined by atomic force microscopy (AFM) and high-throughput… More >

Zhu Zeng^1,*, Zuquan Hu¹, Qinni Zheng¹, Xiaoli Xu¹, Rong Dong¹, Hui Xue¹, Hui Yang¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 68-69, 2019, DOI:10.32604/mcb.2019.07085

Abstract Dendritic cells (DCs) play a crucial role in initiating and amplifying both the innate and adaptive immune responses [1]. Clinically, the DCs-based immunotherapy against cancer is considered one of the most promising therapies to overcome cancers, but there are still many challenges need to be overcome [2]. The motility of DCs is especially crucial for migration of immature DCs into peripheral tissue and dynamic physical interaction between mature DCs and naive T cells in the secondary lymph node. This study focuses on the investigations of DCs at different differentiation stages and under various suppressive cytokines… More >

Ning Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 21-21, 2019, DOI:10.32604/mcb.2019.07550

Abstract Decades ago YC Fung proposed that mechanical stress could have substantial impacts on remodeling and growth of living tissues. Fung also proposed the concept of residual stress in blood vessels and quantified residual stress in excised arteries [1]. However, how stress influences cell and tissue functions remains elusive. At the cellular level, we have quantified myosin II mediated pre-existing tensile stress (prestress) in living cells and demonstrated that the prestress (the endogenous cytoskeletal tension) regulates cell stiffness, gene expression, and long-distance stress propagation in the cytoplasm to activate enzymes [2]. The prestress even impacts on… More >

Syed Muhammad Saqlain Shah^1,*, Tahir Afzal Malik², Robina khatoon¹, Syed Saqlain Hassan³, Faiz Ali Shah⁴

CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 535-553, 2019, DOI:10.32604/cmc.2019.07948

Abstract Classification of human actions under video surveillance is gaining a lot of attention from computer vision researchers. In this paper, we have presented methodology to recognize human behavior in thin crowd which may be very helpful in surveillance. Research have mostly focused the problem of human detection in thin crowd, overall behavior of the crowd and actions of individuals in video sequences. Vision based Human behavior modeling is a complex task as it involves human detection, tracking, classifying normal and abnormal behavior. The proposed methodology takes input video and applies Gaussian based segmentation technique followed More >

Wenyu Qu¹, Zhiyang Li^2,*, Junfeng Wu², Yinan Wu³, Zhaobin Liu²

Computer Systems Science and Engineering, Vol.33, No.2, pp. 115-123, 2018, DOI:10.32604/csse.2018.33.115

Abstract Conventional image skeletonization techniques implicitly assume the pixel level connectivity. However, noise inside the object regions destroys the connectivity and exhibits sparseness in the image. We present a skeletonization algorithm designed for these kinds of sparse shapes. The skeletons are produced quickly by using three operations. First, initial skeleton nodes are selected by farthest point sampling with circles containing the maximum effective information. A skeleton graph of these nodes is imposed via inheriting the neighborhood of their associated pixels, followed by an edge collapse operation. Then a skeleton tting process based on feature-preserving Laplacian smoothing More >

Molecular & Cellular Biomechanics, Vol.15, No.1, pp. 21-36, 2018, DOI:10.3970/mcb.2018.015.021

Abstract Dendritic cells (DCs) are the most potent professional antigen presenting cells as now known, which play critical roles in the initiation, programming and regulation of the immune response. Transforming growth factor-β₁ (TGF-β₁), one of the major suppressive cytokines in tumor microenvironment, can deteriorate the biomechanical characteristics and motility of mature dendritic cells (mDCs)，but the underlying molecular mechanisms are not well defined. In this study, the effects of TGF-β₁ on the motilities and T cell priming capabilities of mDCs as well as the molecular regulatory mechanisms were investigated. The results showed that the cytoskeleton (F-actin) organizations of mDCs More >

Mingzhi Luo^1,2, Peili Yu¹, Yang Jin³, Zhili Qian¹, Yue Wang¹, Jingjing Li¹, Peng Shang^2*, Linhong Deng^1*

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 137-157, 2016, DOI:10.3970/mcb.2016.013.155

Abstract Random positioning machine (RPM) and diamagnetic levitation are two essential ground-based methods used to stimulate the effect of microgravity in space life science research. However, the force fields generated by these two methods are fundamentally different, as RPM generates a dynamic force field acting on the surface in contact with supporting substrate, whereas diamagnetic levitation generates a static force field acting on the whole body volume of the object (e.g. cell). Surprisingly, it is hardly studied whether these two fundamentally different force fields would cause different responses in mammalian cells. Thus we exposed cultured MC3T3-E1… More >