Milica Karadzic Kocica¹, Hristina Ugrinovic¹, Dejan Lazovic², Nemanja Karamarkovic², Milos Grujic², Borivoje Lukic³, Oliver Radmili³, Vladimir Cvetic³, Mladen Kocica^2,*

Congenital Heart Disease, Vol.16, No.6, pp. 647-653, 2021, DOI:10.32604/CHD.2021.016923 - 08 July 2021

Abstract A single coronary artery is a very rare condition, commonly associated with other congenital anomalies. It could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the branches. By presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery, we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare More >

Haoyu Wan, Heng Zhang, Zhizhu He^*

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 639-651, 2021, DOI:10.32604/fdmp.2021.012106 - 29 April 2021

Abstract Treating coronary bifurcation stenosis is still a challenging task. Existing procedures still display a relatively small rate of success. This paper aims to investigate numerically the effect of bifurcation lesions with different structures on the dynamics of blood flow and related temperature. The problem geometry is parametrically varied by changing the bifurcation angle and radius. A finite volume method is used to simulate the three-dimensional flow. The effects induced by the structure of the stenosis, the artery bifurcation angle and radius, and the inlet velocity of blood are discussed in terms of flow pattern, pressure More >

Adi Azriff Basri^1,6,*, Mohammad Zuber², Ernnie Illyani Basri¹, Muhammad Shukri Zakaria⁵, Ahmad Fazli Abd Aziz³, Masaaki Tamagawa⁴, Kamarul Arifin Ahmad^1,6

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.3, pp. 531-553, 2021, DOI:10.32604/fdmp.2021.010925 - 29 April 2021

Abstract Paravalvular Leakage (PVL) has been recognized as one of the most dangerous complications in relation to Transcathether Aortic Valve Implantation (TAVI) activities. However, data available in the literature about Fluid Structure Interaction (FSI) for this specific problem are relatively limited. In the present study, the fluid and structure responses of the hemodynamics along the patient aorta model and the aortic wall deformation are studied with the aid of numerical simulation taking into account PVL and 100% TAVI valve opening. In particular, the aorta without valve (AWoV) is assumed as the normal condition, whereas an aorta… More >

Roderick W. J. van Grootel, Allard T. van den Hoven, Dan Bowen, Tijmen Ris, Jolien W. Roos-Hesselink, Annemien E. van den Bosch^*

Congenital Heart Disease, Vol.16, No.3, pp. 221-232, 2021, DOI:10.32604/CHD.2021.013793 - 02 March 2021

Abstract Aims: To assess the prognostic value of left ventricular (LV) global longitudinal strain (GLS) and global longitudinal early diastolic strain rate (GLSre) with regard to cardiovascular events, as congenital aortic stenosis (AoS) is associated with significant mortality and morbidity but predictors for clinical outcome are scarce. Strain analysis provides a robust and reproducible method for early detection of LV dysfunction, which might be of prognostic value. Methods: This prospective study, included clinically stable patients with congenital AoS between 2011–2013. LV GLS and GLSre was performed in the apical 4, 3 and 2-chamber views using Tomtec software.… More >

Samuel Menahem^1,2,*, Arvind Sehgal^3,4

Congenital Heart Disease, Vol.16, No.2, pp. 189-196, 2021, DOI:10.32604/CHD.2021.014903 - 26 January 2021

Abstract Most congenital heart disease (CHD) is readily recognisable in the newborn. Forewarned by previous fetal scanning, the presence of a murmur, tachypnoea, cyanosis and/or differential pulses and saturations all point to a cardiac abnormality. Yet serious heart disease may be missed on a fetal scan. There may be no murmur or clinical cyanosis, and tachypneoa may be attributed to non-cardiac causes. Tachypnoea on day 1 is usually non-cardiac except arising from ventricular failure or a large systemic arteriovenous fistula. A patent ductus arteriosus (PDA) may support either pulmonary or systemic duct dependent circulations. The initially… More >

Yunduo Charles Zhao^1,2,#, Parham Vatankhah^1,#, Tiffany Goh^1,2,3, Jiaqiu Wang⁴, Xuanyi Valeria Chen¹, Moein Navvab Kashani^5,6, Keke Zheng⁷, Zhiyong Li⁴, Lining Arnold Ju^1,2,3,*

Molecular & Cellular Biomechanics, Vol.18, No.1, pp. 1-10, 2021, DOI:10.32604/mcb.2021.012598 - 26 January 2021

Abstract Platelet aggregation plays a central role in pathological thrombosis, preventing healthy physiological blood flow within the circulatory system. For decades, it was believed that platelet aggregation was primarily driven by soluble agonists such as thrombin, adenosine diphosphate and thromboxane A2. However, recent experimental findings have unveiled an intriguing but complementary biomechanical mechanism—the shear rate gradients generated from flow disturbance occurring at sites of blood vessel narrowing, otherwise known as stenosis, may rapidly trigger platelet recruitment and subsequent aggregation. In our Nature Materials 2019 paper [1], we employed microfluidic devices which incorporated micro-scale stenoses to elucidate the… More >

Domenico Sirico¹, Biagio Castaldi^1,*, Giuseppe Tarantini², Giovanni Di Salvo¹

Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863 - 02 November 2020

Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically More >

Anber Saleem^1,2, Salman Akhtar³, Sohail Nadeem^3,*, Alibek Issakhov⁴, Mehdi Ghalambaz^5,6

CMES-Computer Modeling in Engineering & Sciences, Vol.125, No.2, pp. 565-577, 2020, DOI:10.32604/cmes.2020.011883 - 12 October 2020

Abstract The blood flow through a catheterized artery having a mild stenosis at the wall together with a blood clot at the centre is studied in the current investigation. Stenosis can occur in vessels carrying blood to brain (i.e., Carotid arteries), Renal arteries that supply blood to kidneys etc. The flow is refined in such vessels by application of catheter. We have used a Newtonian viscous fluid model and also distinct shapes of stenosis, (i.e., symmetric and non-symmetric shapes) are considered for this study. The entropy generation together with viscous dissipation is also taken into account… More >

Alexander C. Egbe, William R. Miranda, Patricia A. Pellikka, Sorin V. Pislaru, Barry A. Borlaug, Srikanth Kothapalli, Sindhura Ananthaneni, Harigopal Sandhyavenu, Maria Najam, Mohamed Farouk Abdelsamid, Heidi M. Connolly

Congenital Heart Disease, Vol.14, No.4, pp. 657-664, 2019, DOI:10.1111/chd.12768

Abstract Background: We hypothesized that echocardiographic indices of right ventricular to pulmonary artery (RV‐PA) coupling were comparable to cardiac magnetic resonance imaging (CMRI)‐derived RV volumetric indices in predicting disease severity in chronic pulmonary regurgitation (PR).
Methods: Patients with ≥ moderate PR (2003‐2015) with and without prior CMRI scans were enrolled into the study cohort and validation cohort, respectively. Endpoint was to determine the association between noninvasive RV‐PA coupling in‐ dices (tricuspid annular plane systolic excursion/right ventricular systolic pressure [TAPSE/RVSP] and fractional area change [FAC]/RVSP ratio) and markers of disease severity, and compared this association to that of CMRI‐derived… More >

Donald J. Hagler^1,2, William R. Miranda², Brielle J. Haggerty¹, Jason H. Anderson¹, Jonathan N. Johnson¹, Frank Cetta^1,2, Sameh M. Said^1,3, Nathaniel W. Taggart¹

Congenital Heart Disease, Vol.14, No.4, pp. 571-581, 2019, DOI:10.1111/chd.12757

Abstract Background: Stenosis of the venous connections and conduits is a well‐known late complication of the Fontan procedure. Currently, data on the outcomes of percuta‐ neous intervention for the treatment of extra‐ or intracardiac conduits and lateral tunnel baffles obstruction are limited. In an attempt to better define the nature and severity of the stenosis and the results of catheter interventional management, we reviewed Fontan patients with obstructed extra‐ or intracardiac conduits and lateral tunnel baffles.
Methods: Retrospective review of all Fontan patients who had cardiac catheteriza‐ tion from January 2002 to October 2018 was performed. Hemodynamic and… More >