Rachel L. Hansen^1,2, Iman Naimi³, Hongyue Wang¹, Nader Atallah^3,4, Frank Smith^3,4, Craig Byrum^3,4, Daniel Kveselis^3,4, Glenn Leonard^1,5, Rajiv Devanagondi¹, Matthew Egan^3,4

Congenital Heart Disease, Vol.14, No.6, pp. 1037-1045, 2019, DOI:10.1111/chd.12788

Abstract Objective: Evaluate long‐term outcomes following balloon pulmonary valvuloplasty (BPV) for pulmonary stenosis (PS).
Background: Long‐term data following BPV is limited to small, single center studies.
Methods: BPV from April 12, 1985 to January 7, 2015 from three centers were included. Outcomes studied were ≥ moderate PI by echocardiogram and residual PS ≥ 40 mm Hg. Risk factors for ≥ moderate PI, residual PS, and repeat intervention were assessed by univariate and multivariate analysis.
Results: Among 254 patients, mean age at BPV was 3.8 years (range 1 day‐67 years), initial PS catheter gradient was 56 mm Hg (IQR 40‐70), 19%… More >

Seul Gi Cha¹, Mi Kyung Song¹, Sang Yun Lee¹, Gi Beom Kim¹, Jae Gun Kwak², Woong Han Kim², Eun Jung Bae¹

Congenital Heart Disease, Vol.14, No.5, pp. 684-690, 2019, DOI:10.1111/chd.12810

Abstract Objective: Cardiovascular lesions are the leading cause of morbidity and mortality in patients with Williams syndrome. Recent studies have rebutted conventional reports about the natural course of cardiovascular anomalies in Williams syndrome.
Design: Retrospective study.
Setting: Single tertiary center.
Patients: Eighty patients with Williams syndrome followed up for more than 5 years.
Interventions: Not applicable.
Outcome Measures: Long‐term outcome of cardiovascular lesions, peak velocity change in obstructive cardiovascular lesions over time, post‐interventional courses of disease‐specific intervention, and intervention‐free survival of obstructive cardio‐ vascular lesions.
Results: The median follow‐up duration was 11.0 (5.1‐28.3) years. Among 80 pa‐ tients, supravalvular aortic stenosis (87.5%) was… More >

Kailyn Anderson¹, James Cnota^2,3, Jeanne James^4,5, Erin M. Miller^2,3, Ashley Parrott³, Valentina Pilipenko^1,2, Kathryn Nicole Weaver^1,2, Amy Shikany³

Congenital Heart Disease, Vol.14, No.2, pp. 264-273, 2019, DOI:10.1111/chd.12721

Abstract Objective: To evaluate the prevalence of Noonan spectrum disorders (NSD) in a pediatric population with valvar pulmonary stenosis (vPS) and identify the clinical characteristics that differentiate those with NSD from those without NSD.
Design: A retrospective chart review of 204 patients diagnosed with vPS between 9/1/2012 and 12/1/2016 at a pediatric medical center was performed. The quantitative features of vPS, genetic diagnosis information, and phenotypic characteristics of Noonan syndrome were collected. Chi‐square test, Fisher’s exact test, t test, Wilcoxon rank‐sum test, and ANOVA were used for comparisons among the groups. Logistic regression was used to test for… More >

Long Yu¹, Kesong Xu¹, Jun Wan², Haiyan Lu^3,*, Shengzhang Wang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 835-844, 2019, DOI:10.32604/cmes.2019.07428

Abstract Fractional flow reserve (FFR) computed from computed tomography angiography (CTA), i.e., FFR_CT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery stenosis. It has also been suggested to be used in the assessment of carotid artery stenosis. The wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid stenosis. This work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFR_CT in carotid stenosis. Models of carotid stenosis are established based on CTA image data using computer-aided design… More >

Ram P. Ghosh¹, Matteo Bianchi¹, Gil Marom², Oren M. Rotman¹, Brandon Kovarovic¹, Danny Bluestein^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

Abstract This article has no abstract. More >

Caili Li¹, Jing Yao², Chun Yang³, Di Xu², Liang Wang⁴, Dalin Tang^4,5,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 77-78, 2019, DOI:10.32604/mcb.2019.05745

Abstract Pulmonary valve stenosis (PVS) is one common post-operative problem in patients with tetralogy of Fallot (TOF) after repair. Congenital bicuspid pulmonary valve (BPV) is a condition of valvular stenosis, and the occurrence of congenital BPV is often associated with TOF. Compared with the biomechanical simulation model of the bicuspid aortic valve, the BPV is often neglected. In this study, we developed a dynamic biomechanical model of a simulated normal pulmonary root (PR) with tri-leaflet and a model of simulated PR with BPV in patients with repaired TOF in order to describe the effect of geometric… More >

Guangyu Zhu¹, Yuan Wei¹, Qi Yuan^1,*, Ge Yan², Jian Yang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 55-56, 2019, DOI:10.32604/mcb.2019.05730

Abstract This article has no abstract. More >

Chunbo Jin¹, Youjun Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 51-52, 2019, DOI:10.32604/mcb.2019.05728

Abstract Coronary heart disease (CHD) is one of the most common forms of heart disease, which means that coronary stenosis can cause insufficient blood supply to the heart and lead to coronary heart disease. Coronary artery bypass grafting (coronary bypass) is often used in the treatment of patients with coronary heart disease. After surgery, because the stenosis of the coronary artery is not completely occluded, the blood flow through it will compete with the blood flow of the graft, making it possible to transplant blood vessels. The blood flow is affected, reducing long-term permeability. When the… More >

Xu Zhang^1,‡, Jie Gao^2,‡, Xinke Yao¹, Zhengze Dai^3,4, Gelin Xu^2,*, Yan Cai^1,*, Zhiyong Li^1,5,*

Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 27-39, 2019, DOI:10.32604/mcb.2019.06140

Abstract Digital subtraction angiography (DSA) is often used to evaluate the morphological and pathological changes of cerebral arteries in clinical practice. This study aims to explore the possibility of assessing cerebral hypoperfusion with DSA in patients with carotid stenosis. Thirty patients with a mild to severe stenosis on one side, and a mild stenosis on the other side of the carotid artery were recruited. Frontal, parietal, temporal and occipital lobes were chosen as regions of interest for measuring the quantitative perfusion parameters from their time-density curves (TDCs) of DSA images. The perfusion parameters were compared between… More >

Hitesh Agrawal^1,2, Douglas Moodie¹, Athar M. Qureshi^1,2, Alisa A. Acosta³, Jose A. Hernandez⁴, Michael C. Braun³, Henri Justino^1,2

Congenital Heart Disease, Vol.13, No.3, pp. 349-356, 2018, DOI:10.1111/chd.12608

Abstract Background: Renovascular hypertension (RVH) can be caused by renal artery stenosis (RAS) and/ or middle aortic syndrome (MAS).
Methods: Patients who received surgical or transcatheter treatment for RVH between 1/1991 and 11/2017 were retrospectively reviewed using age = adjusted blood pressure ratio (BPR).
Results: Fifty-three patients diagnosed with RVH at a median age of 4.5 (0–18) years were included. Vascular involvement ranged from MAS with RAS (20), RAS only (32), and MAS only (1). The first intervention was transcatheter in 47 patients (transcatheter group: angioplasty = 41, stenting = 5, and thrombectomy = 1), and surgical in 6… More >