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  • Open Access


    Influence of non-Newtonian Properties of Blood on the Wall Shear Stress in Human Atherosclerotic Right Coronary Arteries

    Biyue Liu, Dalin Tang

    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 73-90, 2011, DOI:10.3970/mcb.2011.008.073

    Abstract The objective of this work is to investigate the effect of non-Newtonian properties of blood on the wall shear stress (WSS) in atherosclerotic coronary arteries using both Newtonian and non-Newtonian models. Numerical simulations were performed to examine how the spatial and temporal WSS distributions are influenced by the stenosis size, blood viscosity, and flow rate. The computational results demonstrated that blood viscosity properties had considerable effect on the magnitude of the WSS, especially where disturbed flow was observed. The WSS distribution is highly non-uniform both temporally and spatially, especially in the stenotic region. The maximum More >

  • Open Access


    Influence of Arterial Wall Compliance on the Pressure Drop across Coronary Artery Stenoses under Hyperemic Flow Condition

    Bhaskar Chandra Konala, Ashish Das, Rupak K Banerjee∗,†

    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 1-20, 2011, DOI:10.3970/mcb.2011.008.001

    Abstract Hemodynamic endpoints such as flow and pressure drop are often measured during angioplasty procedures to determine the functional severity of a coronary artery stenosis. There is a lack of knowledge regarding the influence of compliance of the arterial wall-stenosis on the pressure drop under hyperemic flows across coronary lesions. This study evaluates the influence in flow and pressure drop caused by variation in arterial-stenosis compliance for a wide range of stenosis severities. The flow and pressure drop were evaluated for three different severities of stenosis and tested for limiting scenarios of compliant models. The Mooney-Rivlin… More >

  • Open Access


    A Fast-Fractional Flow Reserve Simulation Method in A Patient with Coronary Stenosis Based on Resistance Boundary Conditions

    Wenxin Wang1,2, Dalin Tang2, Boyan Mao1, Bao Li1, Xi Zhao3, Jian Liu4, Youjun Liu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI:10.31614/cmes.2018.04219

    Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was More >

  • Open Access


    Hemodynamics of Enhanced External Counterpulsation with Different Coronary Stenosis

    Sihan Chen1, Bao Li1, Haisheng Yang1, Jianhang Du2, Xiaoling Li2, Youjun Liu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 149-162, 2018, DOI:10.31614/cmes.2018.04133

    Abstract Enhanced external counterpulsation (EECP) is able to treat myocardial ischemia, which is usually caused by coronary artery stenosis. However, the underlying mechanisms regarding why this technique is effective in treating myocardial ischemia remains unclear and there is no patient-specific counterpulsation mode for different rates of coronary artery stenosis in clinic. This study sought to investigate the hemodynamic effect of varied coronary artery stenosis rates when using EECP and the necessity of adopting targeted counterpulsation mode to consider different rates of coronary artery stenosis. Three 3-dimensional (3D) coronary models with different stenosis rates, including 55% (Model… More >

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