Bhaskar Chandra Konala^∗, Ashish Das^∗, Rupak K Banerjee^∗,†

Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 1-20, 2011, DOI:10.3970/mcb.2011.008.001

Abstract Hemodynamic endpoints such as flow and pressure drop are often measured during angioplasty procedures to determine the functional severity of a coronary artery stenosis. There is a lack of knowledge regarding the influence of compliance of the arterial wall-stenosis on the pressure drop under hyperemic flows across coronary lesions. This study evaluates the influence in flow and pressure drop caused by variation in arterial-stenosis compliance for a wide range of stenosis severities. The flow and pressure drop were evaluated for three different severities of stenosis and tested for limiting scenarios of compliant models. The Mooney-Rivlin model defined the non-linear material… More >

Wenxin Wang^1,2, Dalin Tang², Boyan Mao¹, Bao Li¹, Xi Zhao³, Jian Liu⁴, Youjun Liu^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI: 10.31614/cmes.2018.04219

Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was performed by coupling the 3D… More >

Sihan Chen¹, Bao Li¹, Haisheng Yang¹, Jianhang Du², Xiaoling Li², Youjun Liu^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 149-162, 2018, DOI: 10.31614/cmes.2018.04133

Abstract Enhanced external counterpulsation (EECP) is able to treat myocardial ischemia, which is usually caused by coronary artery stenosis. However, the underlying mechanisms regarding why this technique is effective in treating myocardial ischemia remains unclear and there is no patient-specific counterpulsation mode for different rates of coronary artery stenosis in clinic. This study sought to investigate the hemodynamic effect of varied coronary artery stenosis rates when using EECP and the necessity of adopting targeted counterpulsation mode to consider different rates of coronary artery stenosis. Three 3-dimensional (3D) coronary models with different stenosis rates, including 55% (Model 1), 65% (Model 2), and… More >