Joon Yau Leong^1,*, Vignesh Prasad², Carlos J. Perez Kerkvliet¹, Andrew A. Wagner³, Richard E. Link⁴, Mihir S. Shah¹

Canadian Journal of Urology, Vol.32, No.5, pp. 469-475, 2025, DOI:10.32604/cju.2025.066348 - 30 October 2025

Abstract In recent years, the introduction of the Da Vinci Single Port (SP) robotic platform has opened new doors for the treatment of localized renal masses. This technology, particularly when utilized via a regionalized retroperitoneal (RP) approach, offers several distinct advantages that may improve patient recovery. These advantages include easier access to both anterior and posterior renal tumors, avoidance of the peritoneal cavity with complicating adhesions, and simplified supine positioning, potentially reducing the risk of musculoskeletal or nerve injuries. Yet, the learning curve for RP surgery remains steep due to the unfamiliarity of many surgeons with More >

Andrea Panunzio¹, Rossella Orlando¹, Federico Greco^2,3, Giovanni Mazzucato⁴, Floriana Luigina Rizzo¹, Serena Domenica D’Elia¹, Antonio Benito Porcaro⁵, Alessandro Antonelli⁵, Alessandro Tafuri^1,6,*

Canadian Journal of Urology, Vol.32, No.5, pp. 375-384, 2025, DOI:10.32604/cju.2025.066140 - 30 October 2025

Abstract Background: The Barthel Index (BI) measures the level of patient independence in activities of daily living. This review aims to summarize current evidence on the use of the BI in urology, highlighting its potential as a tool for assessing patients prior to surgery. Materials and methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted for studies evaluating the BI in patients undergoing urologic surgery, following Systematic Review and Meta-analyses (PRISMA) guidelines. The BI was investigated both as a descriptor of baseline or postoperative health status and a prognostic indicator. A qualitative… More >

Takeshi Toyozumi^1,*, Hideaki Shimada², Hisahiro Matsubara¹

Oncology Research, Vol.33, No.11, pp. 3185-3206, 2025, DOI:10.32604/or.2025.065818 - 22 October 2025

Abstract Cancer immunotherapy has long been established as an important treatment option for cancers. In particular, Immune Checkpoint Inhibitor (ICI) has been reported to be effective against various gastrointestinal cancers (esophageal cancer, gastric cancer, colorectal cancer); however, the treatment phase in which ICI should be used and how it should be incorporated into the treatment strategy vary depending on the cancer type being treated. Multiple clinical trials and basic research on ICIs are currently underway, and new insights from these results will continue to change the clinical treatment strategy of gastrointestinal cancers. While it is desirable… More >

Batyrkhan Omarov^1,2,3,4,*

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 2195-2253, 2025, DOI:10.32604/cmc.2025.064799 - 23 September 2025

Abstract Deep learning now underpins many state-of-the-art systems for biomedical image and signal processing, enabling automated lesion detection, physiological monitoring, and therapy planning with accuracy that rivals expert performance. This survey reviews the principal model families as convolutional, recurrent, generative, reinforcement, autoencoder, and transfer-learning approaches as emphasising how their architectural choices map to tasks such as segmentation, classification, reconstruction, and anomaly detection. A dedicated treatment of multimodal fusion networks shows how imaging features can be integrated with genomic profiles and clinical records to yield more robust, context-aware predictions. To support clinical adoption, we outline post-hoc explainability More >

Jae Sung Son¹, Soo-Jin Kim^2,*

Congenital Heart Disease, Vol.20, No.4, pp. 421-440, 2025, DOI:10.32604/chd.2025.070250 - 18 September 2025

Abstract Background: Advancements in diagnostic tools, surgical techniques, and long-term management have significantly improved survival among individuals with congenital heart disease (CHD), leading to an evolving epidemiologic profile characterized by increasing procedural complexity and a growing adult CHD population. This study aimed to examine nationwide trends in CHD surgeries over a 17-year period, with a focus on temporal shifts in surgical volume, procedural complexity, and age-specific incidence. Methods: A total of 41,608 CHD surgeries and 85,417 surgical procedures performed between 2002 and 2018 were identified from a nationwide health insurance database. Temporal trends were evaluated using segmented… More >

Hande İştar^1,#,*, Buğra Harmandar¹, Melike Korkmaz Toker², Fulden Cantaş Türkiş³

Congenital Heart Disease, Vol.20, No.4, pp. 503-517, 2025, DOI:10.32604/chd.2025.068540 - 18 September 2025

Abstract Background: The neutrophil–lymphocyte ratio (NLR) is a simple, cost-effective marker of systemic inflammation. This study aims to evaluate the association between perioperative NLR and postoperative outcomes in pediatric patients undergoing congenital heart surgery with cardiopulmonary bypass (CPB). Methods: We retrospectively reviewed 70 patients under 18 years of age who underwent surgery between 2018 and 2023. NLR was measured preoperatively and on postoperative days (POD) 0, 1, 2, 3, and 6. Receiver operating characteristic analysis identified optimal cutoffs, and associations with postoperative outcomes were assessed. Results: The preoperative NLR cutoff of 1.14 (AUC = 0.75) was associated with More >

Stamatios Katsimperis^1,*, Lazaros Tzelves¹, Georgios Feretzakis², Themistoklis Bellos¹, Panagiotis Deligiannis¹, Andreas Skolarikos¹, Athanasios Papatsoris¹, Iraklis Mitsogiannis¹

Canadian Journal of Urology, Vol.32, No.4, pp. 271-282, 2025, DOI:10.32604/cju.2025.066395 - 29 August 2025

Abstract Background: Accurate complication reporting in endourology remains challenging, with the Clavien-Dindo Classification and Comprehensive Complication Index being the most commonly used systems. This study aimed to compare surgical outcomes and complication reporting in ureterolithotripsy (URL), percutaneous nephrolithotomy (PCNL), and extracorporeal shock wave lithotripsy (ESWL) using both systems. Methods: This prospective, single-center, non-interventional study included 473 patients undergoing URL, PCNL, or ESWL from October 2022 to October 2024. Demographic, stone-related, and procedural variables were recorded. Complications were classified using the CDC, and cumulative morbidity was assessed using CCI. Statistical analyses, including univariate and multivariate regression, were… More >

Matthew S. Lee, Trey R. Sledge, Amanda K. Seyer, Robert Qi, Kevin Koo^*

Canadian Journal of Urology, Vol.32, No.4, pp. 325-333, 2025, DOI:10.32604/cju.2025.064255 - 29 August 2025

Abstract While cystolitholapaxy for bladder stones is commonly performed using a transurethral approach, large or complex stone burdens in patients with complex lower urinary tract anatomy may make this inefficient or infeasible. Percutaneous cystolitholapaxy is a safe, effective, minimally invasive alternative for diverse indications, including patients with benign prostatic hyperplasia, urethral stricture disease, closed bladder neck, continent catheterized channel, or other urinary diversion. In this article, we review the indications for and advantages of percutaneous cystolitholapaxy and describe our step-by-step technique for this procedure, including representative imaging and favored equipment. We also discuss preoperative and postoperative More >

Yushen Fang¹, Zechen Li¹, Jiahong Li¹, Kaiyu Wang¹, Gang Xu¹, Shusheng Wen^1,2, Jimei Chen^1,2, Jian Zhuang^1,2, Haiyun Yuan^1,2,*, Xiaobing Liu^1,2,*

Congenital Heart Disease, Vol.20, No.3, pp. 357-368, 2025, DOI:10.32604/chd.2025.066817 - 11 July 2025

Abstract Background: Totally thoracoscopic surgery (TTS) and right lateral thoracotomy (RLT) are both extensively utilized in the surgical repair for atrial septal defect (ASD). However, RLT is generally considered in low-weight pediatric patients as a result of restricted surgical exposure. This study aims to introduce an RLT approach for ASD repair in adults and compare its clinical outcomes with TTS. Methods: We conducted a retrospective analysis of the clinical data of 23 adult patients who underwent ASD repair at Guangdong Provincial People’s Hospital between June and October 2024. Patients were divided into two groups based on the… More >

Joshua Winograd^1,#, Rebecca Kindler^2,#, Cassidy Lleras², Alia Codelia-Anjum³, Naeem Bhojani⁴, Dean Elterman⁵, Michael A. Diefenbach³, Daniel Ufearo², Katharine Kechejian², Siri Drangsholt², Bilal Chughtai^3,*

Canadian Journal of Urology, Vol.32, No.3, pp. 219-227, 2025, DOI:10.32604/cju.2025.064404 - 27 June 2025

Abstract Introduction: Benign prostatic hypertrophy (BPH) is a common condition affecting men later in life, significantly impacting quality of life (QOL). Surgical intervention is often pursued when medical management fails, but patient satisfaction with outcomes varies. Decisional regret can affect perceived success and patient satisfaction post-surgery. This study evaluates the relationship between post-surgical symptoms and decisional regret across BPH procedures. Methods: A prospective, multicenter cohort study included 54 patients undergoing BPH surgery between March 2023 and February 2024. Patients completed the International Prostate Symptom Score-QOL (IPSS-QOL) scale preoperatively and at least three months postoperatively, along with… More >