Noriko Ninomiya, Satoshi Tamada, Minoru Kato, Takeshi Yamasaki, Taro Iguchi, Tatsuya Nakatani

Canadian Journal of Urology, Vol.22, No.3, pp. 7798-7804, 2015

Abstract Introduction: We investigated therapeutic outcomes in consecutive patients with metastatic renal cell carcinoma treated with targeted anticancer agents from 2008 to 2014 in order to determine the efficacy of adverse event management for such agents and the best sequence in which to use them.
Materials and methods: We analyzed 132 consecutive patients who had taken targeted anticancer agents for metastatic renal cell carcinoma. Of these, 101 patients received therapy between 2008 and 2011 (pioneer group) and 31 patients received therapy between 2011 and 2014 (contemporary group). Patients of the contemporary group were provided with aggressive adverse… More >

Kelvin A. Moses¹, Andrew Winer¹, John P. Sfakianos¹, Stephen A. Poon¹, Matthew Kent², Melanie Bernstein¹, Paul Russo¹, Guido Dalbagni¹

Canadian Journal of Urology, Vol.21, No.2, pp. 7201-7206, 2014

Abstract Introduction: Penile cancer is a rare malignancy, and few guidelines are available to define treatment paradigms. For greater understanding of the natural history of surgically treated penile cancer, we analyzed the experience at our institution.
Materials and methods: Using an institutional database, we identified 127 patients treated for squamous cell carcinoma of the penis from 1995-2011. Cancer-specific survival (CSS) was calculated using the Kaplan-Meier method. Survival data were compared using the log-rank test. The difference in risk of cancer-specific death by lymph node status and histological grade was determined by univariate Cox regression analysis.
Results: Five… More >

Perissé P¹, R Lovey², ML Molinelli¹, M Scandaliaris²

Phyton-International Journal of Experimental Botany, Vol.83, pp. 275-281, 2014, DOI:10.32604/phyton.2014.83.275

Abstract Cologania broussonetii (Balb.) DC. stands out as valuable perennial, native forage that grows in northwestern Argentina, Cordoba hills and San Luis Province. The objectives of this study were to establish the vegetative and reproductive structures in function of the strategies and survival tactics of Cologania broussonetii. The specimens were collected in the Pan de Azúcar loaf mountain, Córdoba, and in the experimental plots of the FCA, UNC, and were then deposited in the Herbarium ACOR and in the Seed Collection. Seedlings were obtained from germination assays. Cross section cuts were performed on the survival structures of adult… More >

Mark D. Tyson¹, Paul E. Andrews¹, David A. Etzioni², Robert G. Ferrigni¹, Mitchell R. Humphreys¹, Scott K. Swanson¹, Erik P. Castle¹

Canadian Journal of Urology, Vol.20, No.2, pp. 6702-6706, 2013

Abstract Introduction: To evaluate the influence of marriage on the survival outcomes of men diagnosed with prostate cancer.
Materials and methods: We examined 115,922 prostate cancer cases reported to the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2003. Multivariate Cox regression techniques were used to study the relationship of marital status and prostate cancer-specific and overall mortality.
Results: Married men comprised 78% of the cohort (n = 91,490), while unmarried men (single, divorced, widowed, and separated) comprised 22% of the cohort (n = 24,432). Married men were younger (66.4 versus 67.8 years, p < 0.0001), more… More >

Daniel J. Canter¹, Katherine Mallin², Robert G. Uzzo³, Brian L. Egleston³, Jay Simhan³, John Walton³, Marc C. Smaldone³, Viraj A. Master¹, Gennady Bratslavsky⁴, Alexander Kutikov³

Canadian Journal of Urology, Vol.20, No.5, pp. 6915-6921, 2013

Abstract Introduction: To assess the impact of size at presentation in patients with adrenocortical carcinoma (ACC) on rates of synchronous metastatic disease and survival following resection using a large administrative dataset.
Materials and methods: We queried the National Cancer Database (NCDB) dataset to assemble a cohort of patients with ACC based on SEER staging (1985-2000). Patients were stratified into three groups based on surgical tumor size cutoffs: < 4 cm, 4 cm-6 cm, and > 6 cm. Rates of metastatic disease at presentation in all ACC patients as well as relative survival for patients after resection of localized… More >

Nathan A. Bockholt¹, Eric M. DeRoo¹, Kenneth G. Nepple¹, Joseph M. Modrick², Mark C. Smith², Bernard Fallon¹, A. Curtis Hass², Chad R. Tracy¹, James A. Brown¹

Canadian Journal of Urology, Vol.20, No.5, pp. 6907-6912, 2013

Abstract Introduction: We report the first 100 patients who underwent prostate brachytherapy as monotherapy with 125I at an institution with moderate volume radical prostatectomy but low volume brachytherapy (< 2 cases per month). Learning curve and quality improvement was assessed by way of achieving prescription dose targets.
Materials and methods: From May 2002 to August 2006, 100 patients underwent prostate 125I brachytherapy monotherapy via preplanned approach. Preoperative planned dose to 100% of prostate gland (D100) was 145 Gy and postoperative confirmed dose was assessed by computed tomography. The cohort was divided into quartiles and recurrence was assessed using… More >

Pascal Mouracade^1,2, Michel Velten², Marc Gigante³, Olivier Alenda¹, Guillaume Ploussard¹, Frederic Obadia³, Marc Olivier Timsit¹, Arnaud Mejean¹

Canadian Journal of Urology, Vol.19, No.1, pp. 6105-6110, 2012

Abstract Introduction: This study aims to assess the influence of different prognostic factors on the survival of upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy and to investigate whether these factors have independent prognostic significance.
Materials and methods: A retrospective review of institutional databases from two teaching hospitals identified 269 consecutive patients with UTUC managed with nephroureterectomy between 1985 and 2005. The mean follow-up was 80.6 months (median 70.3 months), completed until January 2009. Tumor location and other clinicopathological variables were analyzed in relation to survival. Data collected included age, gender, tumor characteristics (pT stage, grade, lymph node… More >

Mark S. Soloway, Viacheslav Iremashvili, Michael A. Gorin, Ahmed Eldefrawy, Ramgopal Satyanarayana, Murugesan Manoharan

Canadian Journal of Urology, Vol.19, No.3, pp. 6280-6286, 2012

Abstract Introduction: The objective of this report is to describe the oncologic outcomes of men with margin-positive prostate cancer who were managed expectantly following radical prostatectomy.
Materials and methods: Between January 1992 and January 2011, 2166 men underwent an open radical prostatectomy by a single surgeon. Of these patients, 1592 (74%) had complete data and met the inclusion criteria of negative lymph nodes and no history of neoadjuvant or adjuvant therapy. This cohort was dichotomized by the presence or absence of at least one positive surgical margin. Groups were compared for differences in recurrence-free and overall survival.
Results: In… More >

Morgan Rouprêt^1,3, David R. Yates^1,3, Justine Varinot^2,3, Véronique Phé^1,3, Emmanuel Chartier-Kastler^1,3, Marc-Olivier Bitker^1,3, Eva Compérat^2,3

Canadian Journal of Urology, Vol.19, No.5, pp. 6459-6464, 2012

Abstract Introduction: To assess the quality of transurethral resection of bladder tumors (TURBTs) performed by "senior" and "junior" urologists for pT1 tumors in terms of detrusor muscle (DM) presence and recurrence rate at 3-month first cystoscopy (RR-FC). Non-muscle invasive bladder cancer (NMIBC) is a heterogeneous group with differing biological potentials. Tumors invading lamina propria (pT1) have an increased propensity for recurrence and progression. Accurate staging at the time of primary TURBT, including the presence of DM, is crucial to avoid understaging and unnecessary delay in definitive treatment.
Materials and methods: We analyzed our maintained bladder tumor database (TURBTs… More >

Neda Sadeghi, Gina M. Badalato, Gregory Hruby, Max Kates, James M. McKiernan

Canadian Journal of Urology, Vol.19, No.5, pp. 6443-6449, 2012

Abstract Introduction: Perioperative blood transfusion (PBT) has been shown to contribute to cancer progression and mortality. This study sought to determine the impact of PBT during radical cystectomy on cancer-specific survival (CSS) and overall survival (OS).
Materials and methods: The Columbia University Urologic Oncology Database was reviewed for patients who underwent a radical cystectomy (RC) from 1989 to 2010 (n = 638). PBT was defined as non-autologous packed red blood cells (PRBC) received during the same hospital stay as the radical cystectomy. Clinical and pathological variables were compared between the cohorts, and survival analysis was performed using the… More >