Robert E. Verloop1, Pieter Koolwijk1, Anton Jan van Zonneveld2, Victor W. M. van Hinsbergh1
European Cytokine Network, Vol.20, No.4, pp. 207-219, 2009, DOI:10.1684/ecn.2009.0174
Abstract Since the initial discovery of endothelial progenitor cells (EPC), and their promise in increasing angiogen-esis
and vasculogenesis, a myriad of papers have highlighted their potential application in experimental and clinical neo-vascularization
and in tissue engineering. However, promising reports are contrasted by other studies that could not find
a role for EPC in neovascularization. Presently, two types of endothelial progenitor cell populations are recognized. The
first population provides early-outgrowth CD34+
/VEGFR-2+ cells, or colony-forming unit endothelial cells (CFU-EC),
which represent myeloid cells with some endothelial properties, but no ability to form endothelial colonies. They can
stimulate neovascularization… More >