J.W. Choi¹, S.H. Yoo¹, J.B. Kim¹, E.J. Park¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.2, No.2, pp. 47-52, 2007, DOI:10.3970/icces.2007.002.047

Abstract A semi-analytical solution by beam theory and finite element solutions are obtained for normal deflection of a plate with a surface crack under tensile stress. The semi-analytical solution consists of the deflection of a beam and the half-space or full-space solution. Also finite element solutions are obtained and compared with these analytical solutions. These solutions can be used as reference data for non-destructive evaluation of a surface crack. More >

Donald F. Ward Jr.^*, William A. Williams^*, Nicole E. Schapiro^*, Samuel R. Christy^*, Genevieve L. Weber^*, Megan Salt, Robert F. Klees^*, Adele Boskey^†, George E. Plopper ^∗,‡

Molecular & Cellular Biomechanics, Vol.4, No.4, pp. 177-188, 2007, DOI:10.3970/mcb.2007.004.177

Abstract Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate downstream signaling including the ERK1/2 pathway, leading to a variety of cellular responses. In this study, we examined the effects of FAK point mutations at tyrosine residues (Y397, Y925, Y861, and Y576/7) on osteogenic differentiation of human mesenchymal stem cells exposed to collagen I and cyclic tensile strain. Our results demonstrate that FAK signaling emanating from Y397, Y925, and to a More >

Kunigal N. Shivakumar¹, Anil Bhargava², Sameer Hamoush³

CMC-Computers, Materials & Continua, Vol.6, No.2, pp. 71-92, 2007, DOI:10.3970/cmc.2007.006.071

Abstract A detailed and accurate three-dimensional finite element stress analysis was conducted on countersunk rivet holes in a plate subjected to tension loading. The analysis included a wide range of countersunk depths, plate thicknesses, countersunk angles and plate widths. The study confirmed some of the previous results, addressed their differences, provided many new results, and investigated countersunk angle and width effects. Using the detailed FE results and the limiting conditions, a general equation for stress concentration was developed and verified. More >

A. Rama Ch,ra Murthy¹, G.S. Palani¹, Nagesh R. Iyer¹

Structural Durability & Health Monitoring, Vol.1, No.3, pp. 203-214, 2005, DOI:10.3970/sdhm.2005.001.203

Abstract This paper presents an improved Wheeler residual stress model for remaining life prediction of the cracked structural components under variable amplitude loading. The improvement to the Wheeler residual stress model is in two folds. One is expressions for the shaping exponent, which are generally obtained through experiments. Another is calculation of effective plastic zone size to incorporate the sequent effects under tensile-compressive overloading. The remaining life prediction has been carried out by employing the linear elastic fracture mechanics (LEFM) principles. Studies on remaining life prediction of cracked plate panels subjected to tensile-compressive overloading have been More >

S. Deguchi^1,2, T. Ohashi², M. Sato²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 125-134, 2005, DOI:10.3970/mcb.2005.002.125

Abstract Actin bundles in vascular endothelial cells (ECs) play a critical role in transmitting intracellular forces between separate focal adhesion sites. However, quantitative descriptions of tension level in single actin bundles in a physiological condition are still poorly studied. Here, we evaluated magnitude of preexisting tension in a single actin bundle of ECs on the basis of measurements of its preexisting stretching strain and tensile properties. Cultured ECs expressing fluorescently-labeled actin were treated with detergents to extract acin bundles. One end of an actin bundle was then dislodged from the substrate by using a microneedle, resulting… More >