Cheng Wang¹, Jianguo Ning¹, Tianbao Ma¹

CMC-Computers, Materials & Continua, Vol.22, No.1, pp. 73-96, 2011, DOI:10.3970/cmc.2011.022.073

Abstract In this paper, we report high resolution simulations using a fifth-order weighted essentially non-oscillatory (WENO) scheme with a third-order TVD Runge-Kutta time stepping method to examine the features of the detonation for gas and condensed explosives. A two-stage chemical reaction model and an ignition and growth model are employed to describe the chemical reaction process for gas and condensed explosives. Based on the Steger-Warming vector flux splitting method, a splitting method is employed when the vector flux does not satisfy the homogeneity property for simulating detonation wave propagation for condensed explosives. The sensibility of flame More >

R. M. Ardito Marretta^∗,†, G. Barbaraci^‡

Molecular & Cellular Biomechanics, Vol.7, No.3, pp. 135-164, 2010, DOI:10.3970/mcb.2010.007.135

Abstract Upon severe DNA damage, p21 acts in a dual mode; on the one hand, it inhibits the cyclin-CDK complex for arresting the G2/M transition and on the other hand, it indirectly becomes an apoptotic factor by activating - in sequence - the retinoblastoma protein, E2F1 and APAF1 expressions. But, in a cancer cells proliferation, the mechanisms of, and participants in, the apoptosis failure remain unclear. Since the p21/p53/Mdm2 proteins network normally involves a digital response in a cancer cell, through an original design of a cell signalling-protein simulator, we demonstrate,in silico, that apoptosis phase instability More >

M. Marigo^1,2, D. L. Cairns¹, M. Davies¹, M. Cook³,A. Ingram^2,4,5, E. H. Stitt¹

CMES-Computer Modeling in Engineering & Sciences, Vol.59, No.3, pp. 217-238, 2010, DOI:10.3970/cmes.2010.059.217

Abstract In this work the complex motion of the Turbulamixer has been measured by Multiple-Positron Emission Particle Tracking (Multiple PEPT) in order to set-up a DEM numerical model. Positron emitting radioactive tracers were attached to three of the pivot bearings on the shaft of the mixer to enable the rotation and translation of the mixer chamber to be tracked in the PEPT camera. The measured movement was mathematically reconstructed and imported into DEM in order to apply the same movement to the modelled vessel. The three-dimensional motion of particles in a vessel located in the Turbula More >

Chun Yang^1,2, Dalin Tang^2,3 Satya Atluri⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.57, No.1, pp. 51-76, 2010, DOI:10.3970/cmes.2010.057.051

Abstract Cardiovascular disease (CVD) is becoming the number one cause of death worldwide. Atherosclerotic plaque rupture and progression are closely related to most severe cardiovascular syndromes such as heart attack and stroke. Mechanisms governing plaque rupture and progression are not well understood. A computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data was introduced to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Participating patients were scanned three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data.… More >

Raquel R. Pinho¹, João Manuel R. S. Tavares¹

CMES-Computer Modeling in Engineering & Sciences, Vol.46, No.1, pp. 51-76, 2009, DOI:10.3970/cmes.2009.046.051

Abstract This work addresses the problem of tracking feature points along image sequences. In order to analyze the undergoing movement, an approach based on the Kalman filtering technique has been used, which basically carries out the estimation and correction of the features' movement in every image frame. So as to integrate the measurements obtained from each image into the Kalman filter, a data optimization process has been adopted to achieve the best global correspondence set. The proposed criterion minimizes the cost of global matching, which is based on the Mahalanobis distance. A management model is employed More >

G. Papaioannou¹, C. Mitrogiannis¹, G. Nianios¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.8, No.2, pp. 41-46, 2008, DOI:10.3970/icces.2008.008.041

Abstract Previous attempts to track skeletal kinematics from sequences of images acquired using biplane dynamic radiography report challenges in automating the tracking technique due to image resolution issues, occlusion from segments appearing synchronously in the field of view and computational load. This translates into many hours of manual work to export the kinematics. The proposed new tracking method tackles the above problems and reduces the time to export kinematics from several hours to less than 3 minutes. More >

N.Kringos¹, A.Scarpas¹, A.P.S. Selvadurai²

CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.3, pp. 147-160, 2008, DOI:10.3970/cmes.2008.028.147

Abstract This paper presents a numerical approach for the modeling of water flow induced mastic erosion from a permeable asphalt mix and is part of an ongoing effort to model moisture-induced damage in asphalt mixes. Due to the complex composite structure of asphalt mixtures, moisture can infiltrate in various ways into the components and have an adverse effect on its mechanical performance. Depending on the gradation of the asphalt aggregates and the mixing procedure, asphalt structures with a variable permeability may result. Open-graded asphalt mixes are designed with a high interconnected air void content to serve More >

Chun Yang¹, Dalin Tang², Chun Yuan³, William Kerwin², Fei Liu³, Gador Canton³, Thomas S. Hatsukami^3,4, Satya Atluri⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.2, pp. 95-108, 2008, DOI:10.3970/cmes.2008.028.095

Abstract Atherosclerotic plaque rupture and progression have been the focus of intensive investigations in recent years. Plaque rupture is closely related to most severe cardiovascular syndromes such as heart attack and stroke. A computational procedure based on meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data was introduced to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Participating patients were scanned three times (T₁,T₂, and T₃, at intervals of about 18 months) to obtain plaque progression data. Vessel wall thickness (WT) changes were used as the measure for plaque progression.… More >

Hong Qian¹

Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 267-278, 2004, DOI:10.3970/mcb.2004.001.267

Abstract In recent single-particle tracking (SPT) measurements on Listeria monocytogenes motility in cells [Kuo and McGrath (2000)], the actin-based stochastic dynamics of the bacterium movement has been analyzed statistically in terms of the mean-square displacement (MSD) of the trajectory. We present a stochastic analysis of a simplified polymerization Brownian ratchet (BR) model in which motions are limited by the bacterium movement. Analytical results are obtained and statistical data analyses are investigated. It is shown that the MSD of the stochastic bacterium movement is a monotonic quadratic function while the MSD for detrended trajectories is linear. Both the More >