Baran Hekimoğlu^*

Energy Engineering, Vol.120, No.7, pp. 1515-1540, 2023, DOI:10.32604/ee.2023.029024 - 04 May 2023

Abstract Two novel improved variants of reptile search algorithm (RSA), RSA with opposition-based learning (ORSA) and hybrid ORSA with pattern search (ORSAPS), are proposed to determine the proportional, integral, and derivative (PID) controller parameters of an automatic voltage regulator (AVR) system using a novel objective function with augmented flexibility. In the proposed algorithms, the opposition-based learning technique improves the global search abilities of the original RSA algorithm, while the hybridization with the pattern search (PS) algorithm improves the local search abilities. Both algorithms are compared with the original RSA algorithm and have shown to be highly… More > Graphic Abstract

Xinyi Zhang, Zimeng Yu, Pingfang Yang^*

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1665-1679, 2023, DOI:10.32604/phyton.2023.029482 - 11 April 2023

Abstract Sacred lotus (Nelumbo nucifera) is a typical aquatic plant, belonging to basal eudicot plant, which is ideal for genome and genetic evolutionary study. Understanding lotus gene diversity is important for the study of molecular genetics and breeding. In this research, public RNA-seq data and the annotated reference genome were used to identify the genes in lotus. A total of 26,819 consensus and 1,081 novel genes were identified. Meanwhile, a comprehensive analysis of gene alternative splicing events was conducted, and a total of 19,983 “internal” alternative splicing (AS) events and 14,070 “complete” AS events were detected in… More >

Hassam Tahir¹, Muhammad Shahbaz Khan¹, Fawad Ahmed², Abdullah M. Albarrak³, Sultan Noman Qasem³, Jawad Ahmad^4,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3517-3535, 2023, DOI:10.32604/cmc.2023.035410 - 31 March 2023

Abstract The COVID-19 outbreak began in December 2019 and was declared a global health emergency by the World Health Organization. The four most dominating variants are Beta, Gamma, Delta, and Omicron. After the administration of vaccine doses, an eminent decline in new cases has been observed. The COVID-19 vaccine induces neutralizing antibodies and T-cells in our bodies. However, strong variants like Delta and Omicron tend to escape these neutralizing antibodies elicited by COVID-19 vaccination. Therefore, it is indispensable to study, analyze and most importantly, predict the response of SARS-CoV-2-derived t-cell epitopes against Covid variants in vaccinated… More >

Cherith Somerville^1,2, Kelsey Kalbfleisch^1,2, Roozbeh Manshaei^1,2, Qiliang Ding^1,2, John B.A. Okello^1,2,3, Rachel Silver⁴, David Chitayat^2,4, Varsha Thakur⁵, Olivier Villemain^5,6,7, Rebekah Jobling^1,2,8,*

Congenital Heart Disease, Vol.18, No.2, pp. 213-218, 2023, DOI:10.32604/chd.2023.023042 - 15 March 2023

Abstract We report a three-year-old male child who presented with congenital valvular defects, right ventricular malformation, and initial developmental delay. Genome sequencing showed rare deleterious biallelic missense variants in PLD1. In his parents’ second pregnancy, echocardiogram at 13 weeks gestation revealed right-sided cardiac malformations resembling the clinical presentation of the family’s first child. Targeted DNA analysis showed that the fetus carried the same biallelic PLD1 variants as their older sibling. This case helps to further delineate the clinical spectrum of PLD1-related defects and highlights the value of both genome sequencing in congenital heart disease and early fetal echocardiography More >

Ji-Yang Zuo^1,2, Huan-Xin Chen^1,2, Zhi-Gang Liu^1,2, Qin Yang^1,2, Guo-Wei He^1,2,*

Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451 - 09 January 2023

Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first… More > Graphic Abstract

Ahmed M. Alghamdi^1,*, Khalid Hamid², Muhammad Waseem Iqbal³, M. Usman Ashraf⁴, Abdullah Alshahrani⁵, Adel Alshamrani⁶

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3795-3810, 2023, DOI:10.32604/cmc.2023.033976 - 31 October 2022

Abstract In various fields, different networks are used, most of the time not of a single kind; but rather a mix of at least two networks. These kinds of networks are called bridge networks which are utilized in interconnection networks of PC, portable networks, spine of internet, networks engaged with advanced mechanics, power generation interconnection, bio-informatics and substance intensify structures. Any number that can be entirely calculated by a graph is called graph invariants. Countless mathematical graph invariants have been portrayed and utilized for connection investigation during the latest twenty years. Nevertheless, no trustworthy evaluation has… More >

MINGZHAO LI¹, QIAN ZHANG², WENBIN HUANG¹, SHIYING ZHANG¹, NAN JIANG², XIAOSHUAI HUANG^3,*, FENG CHEN^2,*

BIOCELL, Vol.47, No.1, pp. 205-214, 2023, DOI:10.32604/biocell.2022.022572 - 26 September 2022

Abstract Cancer progression involves the sonic hedgehog (SHH) pathway, in which the receptor PTCH1 actives the downstream pathways. Dysfunction of PTCH1 can lead to nevoid basal cell carcinoma Syndrome (NBCCs) including neoplastic disease and congenital disorder. To evaluate the relationship between PTCH1 and cancer, we applied the CRISPR/Cas9 system to knock out PTCH1 in oral nontumorous epithelial cells (GMSM-K). Then we screened six PTCH1 variants associated with cleft lip/palate (CL/P), one of the congenital disorders in NBCCs, and generated PTCH1 variant and wild-type recombinant PTCH1^−/− GMSM-K cell lines. Transcriptome sequencing was conducted in these cell lines. The… More >

Khalid Hamid¹, Muhammad Waseem Iqbal^2,*, Muhammad Usman Ashraf³, Ahmed Mohammed Alghamdi⁴, Adel A. Bahaddad⁵, Khalid Ali Almarhabi⁶

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 363-378, 2023, DOI:10.32604/cmc.2023.032271 - 22 September 2022

Abstract Due to a tremendous increase in mobile traffic, mobile operators have started to restructure their networks to offload their traffic. New research directions will lead to fundamental changes in the design of future Fifth-generation (5G) cellular networks. For the formal reason, the study solves the physical network of the mobile base station for the prediction of the best characteristics to develop an enhanced network with the help of graph theory. Any number that can be uniquely calculated by a graph is known as a graph invariant. During the last two decades, innumerable numerical graph invariants… More >

M. Ryan Farrell, Lawrence T. Zhang, Alex J. Vanni

Canadian Journal of Urology, Vol.29, No.1, pp. 11027-11031, 2022

Abstract Duplicated anterior urethras are a rare congenital anomaly that is exceedingly uncommon among adult patients, as surgical correction is often completed during childhood. We present the case of a 33-year-old man with uncorrected duplicated anterior urethras and urinary retention due to severe urethral stricture disease involving both of his uncorrected duplicated anterior urethras. This report highlights an operative management strategy for reconstruction to create a single, unobstructed urethra that terminates in an orthotopic meatus. Further, we provide an overview of the anatomic variants of urethral duplication. More >

Khalid Hamid¹, Muhammad Waseem Iqbal^2,*, Erssa Arif¹, Yasir Mahmood^3,4, Ahmad Salman Khan³, Nazri Kama⁴, Azri Azmi⁴, Atif Ikram^5,6

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5423-5440, 2022, DOI:10.32604/cmc.2022.030927 - 28 July 2022

Abstract Any number that can be uniquely determined by a graph is called graph invariants. During the most recent twenty years’ innumerable numerical graph invariants have been described and used for correlation analysis. In the fast and advanced environment of manufacturing of networks and other products which used different networks, no dependable assessment has been embraced to choose, how much these invariants are connected with a network graph or molecular graph. In this paper, it will talk about three distinct variations of bridge networks with great capability of expectation in the field of computer science, chemistry,… More >