Gang Yuan, Jingzi Quan, Dongfang Dong, Qunying Wang

Oncology Research, Vol.26, No.7, pp. 1037-1046, 2018, DOI:10.3727/096504017X15144748428127

Abstract Gastric carcinoma (GC) remains the second leading cause of cancer-related deaths worldwide. Good biomarkers are of paramount importance for GC therapy. This study aimed to assess the role of long noncoding RNA (lncRNA) CAT104 in GC. We found that CAT104 was highly expressed in human GC NCI-N87, SGC7901, BGC823, BGC803, and AGS cells. Suppression of CAT104 decreased NCI-N87 cell viability, migration, and invasion, but promoted apoptosis. CAT104 knockdown enhanced the expression of microRNA- 381 (miR-381) expression in NCI-N87 cells. miR-381 participated in the regulatory effects of CAT104 on NCI-N87 cell viability, migration, invasion, and apoptosis. More >

Kun Peng¹, Aike Qiao^1,*, Makoto Ohta², Narendra Kurnia Putra², Xinyang Cui¹, Yongliang Mu³, Hitomi Anzai²

CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.1, pp. 17-28, 2018, DOI:10.31614/cmes.2018.04113

Abstract Biodegradable zinc alloy stents are a prospective solution for complications caused by the incompatibility between artery and permanent stents. However, insufficient scaffolding has limited the clinical application of biodegradable zinc alloy stents. Therefore, in this study, a new stent concept was designed to improve the scaffolding. The mechanical performances of the new and a traditional design stent were investigated and compared using finite element analysis (FEA). The new and traditional design stent were expanded to the intended radial displacement of 0.24 mm under the expansion pressure of 0.58 MPa and 0.45 MPa, respectively. Then, a More >

Zhongwei Wang, Yali Wang, Hongtao Ren, Yingying Jin, Ya Guo

Oncology Research, Vol.25, No.4, pp. 571-577, 2017, DOI:10.3727/97818823455816X14760478220149

Abstract Zinc and ring finger 3 (ZNRF3), which belongs to the E3 ubiquitin ligase family, is involved in the progression and development of cancer. However, the expression and function of ZNRF3 in human nasopharyngeal carcinoma (NPC) remain unclear. Thus, the aim of this study was to investigate the role of ZNRF3 in human NPC. Our results showed that ZNRF3 was downregulated in NPC cell lines. Restoration of ZNRF3 significantly inhibited the proliferation of NPC cells and tumor xenograft growth in vivo. In addition, overexpression of ZNRF3 suppressed migration and invasion, as well as attenuated the epithelial–mesenchymal More >

F. Luzi¹, E. Fortunati^1*, A. Jiménez², D. Puglia¹, A. Chiralt², L. Torre¹

Journal of Renewable Materials, Vol.5, No.2, pp. 103-115, 2017, DOI:10.7569/JRM.2016.634135

Abstract Poly(lactic acid) (PLA) based nanocomposites reinforced with 1 wt% of surfactant-modified cellulose nanocrystals (s-CNC) extracted from Posidonia oceanica plant waste and zinc oxide nanoparticles (ZnO NPs) at different concentrations (0.1 and 0.5 wt%) were prepared by solvent casting process. Their thermal, morphological, optical, mechanical and water vapor permeability properties were investigated. Tensile testing showed increased values for strength and deformation at break in PLA based formulations reinforced with s-CNC and ZnO NPs as a consequence of better nanofiller dispersion compared to binary films reinforced only with ZnO NPs. Moreover, the effect of s-CNC and ZnO More >

Qian Li, Jing Jin, Jianghui Liu, Liqun Wang, Yutong He

Oncology Research, Vol.24, No.3, pp. 205-214, 2016, DOI:10.3727/096504016X14648701447896

Abstract We recently found that SLC39A5 (ZIP5), a zinc transporter, is overexpressed in esophageal cancer. Downregulation of ZIP5 inhibited the proliferation, migration, and invasion of the esophageal cancer cell line KYSE170 in vitro. In this study, we found that downregulation of SLC39A5 (ZIP5) by interference resulted in a significant reduction in esophageal cancer tumor volume and weight in vivo. COX2 (cyclooxygenase 2) expression was decreased and E-cadherin expression was increased in the KYSE170K xenografts, which was caused by the downregulation of ZIP5. However, we did not find that the downregulation of ZIP5 caused a change in More >