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  • Open Access

    ARTICLE

    Gene expression profiling of HepG2 cells after treatment with black tea polyphenols

    Jie Zhong1,#, Li Deng2,#, Yu Jiang3, Lianhong Zou3, Huabing Yuan4, Shuang-xiang Tan1,*

    BIOCELL, Vol.42, No.3, pp. 99-104, 2018, DOI:10.32604/biocell.2018.04915

    Abstract This study aimed to determine the effects of black tea polyphenols on gene expression in hepatocellular cancer cells. The total RNA from HepG2 hepatocellular cancer cells treated with black tea polyphenols was subjected to Human 14K cDNA microarray analysis. Real-time PCR and Western blot analysis were conducted to verify microarray data. Black tea polyphenols treatment at the dose of 20 mg/L, 40 mg/L or 80 mg/L for one to three days inhibited the growth of HepG2 cells in a dose and time dependent manner. A total of 48 genes showed more than two-fold change… More >

  • Open Access

    ARTICLE

    Hydrothermal preparation of TiO2-Ag nanoparticles and its antimicrobial performance against human pathogenic microbial cells in water

    Mahmoud MOUSTAFA1, 2, Saad ALAMRI1, Mohamed ELNOUBY3, Tarek TAHA4, M. A. ABU-SAIED5, Ali SHATI1, Mohamed AL-KAHTANI1, Sulaiman ALRUMMAN1

    BIOCELL, Vol.42, No.3, pp. 93-98, 2018, DOI:10.32604/biocell.2018.07014

    Abstract Water contaminated with pathogenic microbes is considered as one of the most common routes for transmitting diseases in human beings. Different methods have been applied for the decontamination of microbes in contaminated water. In the current study, an easy to do hydrothermal method has been used for the preparation of TiO2-Ag nanoparticles. The obtained material was characterised using a scanning electron microscope (SEM) and fourier transform infra-red spectroscopy (FTIR). The morphological appearance of the obtained nanoparticles was in the shape of a sphere with a size range of 60-90 nm. The antimicrobial activity of the prepared More >

  • Open Access

    EDITORIAL

    Editorial – Should we eliminate hands-on laboratories in undergraduate curricula?

    Raj Singh

    Sound & Vibration, Vol.52, No.1, pp. 1-1, 2018, DOI:10.32604/sv.2018.03601

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    The impact of paralog genes: detection of copy number variation in spinal muscle atrophy patients

    Sergio LAURITO1, 2, Juan A. CUETO1, 3, Jimena PEREZ1, María ROQUÉ1, 2

    BIOCELL, Vol.42, No.3, pp. 87-92, 2018, DOI:10.32604/biocell.2018.07016

    Abstract Spinal muscular atrophy (SMA) is caused by dysfunction of the alpha motor neurons of the spinal cord. It is an autosomal recessive disease associated to the SMN1 gene, located in the subtelomeric region of 5q13. A paralog SMN2 gene is located at the centromeric region of the same chromosome, which apparently originated by an ancestral inverted duplication occurring only in humans. The exon sequence differs in two nucleotides in exon 7 and exon 8, which leads to an SMN2 transcript that lacks exon 7 and results in a truncated protein. Part (10%) of the SMN2… More >

  • Open Access

    ARTICLE

    Spontaneous running wheel improves neuroprotection efficacy of ischemic postconditioning in mice following ischemia/reperfusion injury

    Hong YE1,6,#, WeiWei Wang2,#, Yu Ding3,#, XiaoLei Liu4,#, WenJI Jia1, WeiLi Luo1, HuiJuan Fan1, HongQun Zhou1, Jin Wang1, JianLong Ju1, DongMing Zhou7, TianHao Bao5,1,*, YuHong Zhu1,*

    BIOCELL, Vol.42, No.3, pp. 79-86, 2018, DOI:10.32604/biocell.2018.04615

    Abstract Ischemic postconditioning (IP) has been shown to provide protection for ischemia/reperfusion (IR) injury, but its efficacy is limited. In this study we hypothesized that spontaneous running wheel (RW) could improve neuroprotection efficacy of IP for IR. We established mouse models of IR and showed that compared to Sham group, IR group had obvious brain infract and neurological dysfunction. In IR+IP group, brain infract and neurological dysfunction improved compared to IR group. However, in IR+IP+RW group brain infract and neurological dysfunction improved much better. TUNEL assay showed that IP but not RW significantly reduced the number… More >

  • Open Access

    REVIEW

    Adipose-derived mesenchymal stem/stromal cells: from the lab bench to the basic concepts for clinical translation

    Yesica Romina FRONTINI-LÓPEZ1, Aldana Daniela GOJANOVICH1, Diego MASONE1,2, Diego Martín BUSTOS1,3, Marina UHART1

    BIOCELL, Vol.42, No.3, pp. 67-78, 2018, DOI:10.32604/biocell.2018.07013

    Abstract In the last years, much work has shown that the most effective repair system of the body is represented by stem cells, which are defined as undifferentiated precursors that own unlimited or prolonged self-renewal ability, which also have the potential to transform themselves into various cell types through differentiation.All tissues that form the body contain many different types of somatic cells, along with stem cells that are called ‘mesenchymal stem (or stromal) cells’ (MSC). In certain circumstances, some of these MSC migrate to injured tissues to replace dead cells or to undergo differentiation to repair… More >

  • Open Access

    ARTICLE

    Lightweight Biobased Polyurethane Nanocomposite Foams Reinforced with Pineapple Leaf Nanofibers (PLNFs)

    Xiaojian Zhou1,2, Hui Wang1, Jun Zhang2, Zhifeng Zheng1, Guanben Du1,2,*

    Journal of Renewable Materials, Vol.6, No.1, pp. 68-74, 2018, DOI:10.7569/JRM.2017.634150

    Abstract Pineapple leaf nanofibers (PLNFs) extracted from pineapple leaf fiber were used for reinforcing biobased polyurethane foam (BPU). The dispersion performance of PLNF in the foaming mixture system, nanocomposite foaming behavior, cell morphology, cell size, density, compressive strength and dimensional stability were investigated. The viscosity of the mixtures increased with increasing the PLNF content. The addition of a tiny amount of PLNF did not influence the exothermic temperature of the foam system, but reduced the expansion and gel time of the nanocomposite foams. This reduced time was found to increase the production efficiency. Scanning electron More >

  • Open Access

    ARTICLE

    Effects of precipitation changes on the dynamics of sparse elm woodland in Northeastern China

    Yi TANG1,*, Carlos Alberto BUSSO2

    BIOCELL, Vol.42, No.2, pp. 61-66, 2018, DOI:10.32604/biocell.2018.07015

    Abstract Elm (Ulmus pumila L.) is the dominant tree species in the sparse elm woodland, the original vegetation in the Horqin Sandy Land. The effects of changes in precipitation on U. pumila trees have not been fully studied. We determined a dynamic model by considering the five stages in the U. pumila life cycle, i.e. seed, seedling, and juvenile, mature and over-mature tree stages. The effects of changes in precipitation on population density and age structure were then evaluated. Population density, after averaging all study developmental morphology stages, ranged from 16.67 individuals/m2 to 25.01 individuals/m2 under More >

  • Open Access

    EDITORIAL

    Preface: Innovations and Current Trends in Computational Cardiovascular Modeling and Beyond: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications

    Dalin Tang1,2,*, Zhiyong Li1

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 109-113, 2018, DOI:10.31614/cmes.2018.04201

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Associations between CD133, CK19 and G2/M in cirrhotic HCV (genotype-4) patients with or without accompanying tumor

    Hoda M. EL-EMSHATY1, Entsar A. SAAD2, Mona S. GOUIDA3, Zahraa R. ELSHAHAWY1,2

    BIOCELL, Vol.42, No.2, pp. 55-60, 2018, DOI:10.32604/biocell.2018.07009

    Abstract Hepatitis C virus (HCV)-cirrhotic patients have the highest threat of developing hepatocellular carcinoma (HCC) and may be at risk of extra hepatic cancer. The present study was designed to investigate CD133 and CK19 in HCV (genotype-4)-cirrhotic patients with/without HCC or extra hepatic cancer, to assess the degree of their correlation with cell cycle abnormalities and finally to assess the role of their combination as diagnostic tool for discrimination of cirrhotic patients with HCC from those with extra hepatic cancer. The study included 77 HCV-cirrhotic patients and 20 healthy non-disease control group. Patients were categorized… More >

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