Fuzhou Tang¹, Jin Chen¹, Shichao Zhang¹, Zuquan Hu¹, Lina Liu¹, Long Li¹, Yan Ouyang¹, Zhu Zeng^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 40-41, 2019, DOI:10.32604/mcb.2019.07082

Abstract As potent antigen presenting cells, dendritic cells (DCs) are utilized to deliver the signals essential for the initiation of immune responses. The motility of DCs is crucial for migration of immature DCs (imDCs) in peripheral tissue and the interaction between mature DCs (mDCs) and naïve T cells in the secondary lymph node. From biomechanical viewpoint, the deformability of cells is necessary for their motility. Deformation of cells can be divided into active deformation (e.g. chemotaxis) and passive deformation (e.g. migration under shear stress of blood flow). However, there is no detailed study on the deformability More >

Ken-ichi Tsubota^1,2,*, Yuya Kodama¹, Hiroyoshi Aoki², Yutaka Yamagata²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 38-39, 2019, DOI:10.32604/mcb.2019.07285

Abstract We measured a blood flow in a polydimethysiloxane micro channel to reflect the complex geometry of a microvascular network. A flow rate was compared between two working fluids: water and blood. The measured flow rate reflected the bifurcation effects on the apparent viscosity determined by hematocrit, as well as the effects of the surrounding flow channels as bypasses. More >

Peng Jing¹, Xiaolong Wang¹, Shigeho Noda², Xiaobo Gong^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 36-37, 2019, DOI:10.32604/mcb.2019.07111

Abstract The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. The moving behavior and stress distribution of circulating tumor cells under different geometry and flow conditions are important basis for studying the adhesion between circulating tumor cells and vessel walls. In the present work, the motion and deformation of circulating tumor cells in capillary tubes are numerically studied using the immersed boundary method (IBM). The membrane stress distribution of CTCs in confined tubes are investigated with under vessel diameters, hematocrit (Ht) values and capillary numbers (Ca). More >

Peirong Jiang¹, Zhensen Chen², Daniel S. Hippe², Hiroko Watase³, Bin Sun¹, Ruolan Lin¹, Zheting Yang¹, Yunjing Xue^1,*, Xihai Zhao^4,*, Chun Yuan^2,4

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 34-35, 2019, DOI:10.32604/mcb.2019.07394

Abstract This article has no abstract. More >

Navid Mohammad Mirzaei¹, Pak-Wing Fok^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 32-33, 2019, DOI:10.32604/mcb.2019.07088

Abstract Atherosclerosis is a disease considered to be one of the leading causes of death. Understanding the behavior and dynamics of the vessel wall before and after atherosclerosis has been a motivation for many studies. We investigate this phenomenon as a combination of mechanical deformation of the vessel wall along with cell and chemical dynamics that occur within. We consider the vessel wall as a growing hyperelastic material with three layers; intima,media and adventitia. Each of these layers have a different set of mechanical properties [1]. To describe tissue growth, we use morphoelasticity as the mathematical… More >

Caining Zhang¹, Huaguang Li², Xiaoya Guo³, David Molony⁴, Xiaopeng Guo², Habib Samady⁴, Don P. Giddens^4,5, Lambros Athanasiou⁶, Rencan Nie^2,*, Jinde Cao^3,*, Dalin Tang^1,*,7

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 31-31, 2019, DOI:10.32604/mcb.2019.06983

Abstract Cardiovascular diseases are closely associated with deteriorating atherosclerotic plaques. Optical coherence tomography (OCT) is a recently developed intravascular imaging technique with high resolution approximately 10 microns and could provide accurate quantification of coronary plaque morphology. However, tissue segmentation of OCT images in clinic is still mainly performed manually by physicians which is time consuming and subjective. To overcome these limitations, two automatic segmentation methods for intracoronary OCT image based on support vector machine (SVM) and convolutional neural network (CNN) were performed to identify the plaque region and characterize plaque components. In vivo IVUS and OCT… More >

Dominique P. Pioletti^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 29-30, 2019, DOI:10.32604/mcb.2019.07050

Abstract From a mechanical point of view, articular cartilage can be considered as a viscoelastic porous material. Its dissipation capabilities are therefore central for its functional behavior. Based on this observation, we focused our studies of dissipative aspects in cartilage either from a biomechanical or mechanobiological point of view. In particular, we capitalized on the new obtained insight of dissipative behavior or sources in materials for the development of functional biomaterials for cartilage tissue engineering. We pioneered in proposing dissipation as a mechanobiological variable for cartilage tissue engineering [1]. As can be observed on Fig. 1,… More >

Rui Lv¹, Liang Wang¹, Dalin Tang^1,*,2

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 27-28, 2019, DOI:10.32604/mcb.2019.06829

Abstract Medical imaging and image-based computational modeling have been used by many researchers in recent years to quantify atherosclerotic plaque morphological and biomechanical characteristics and predict the coronary plaque growth and rupture processes. However, it has been hard to validate model predictions due to imaging resolution limitation, lack of clinical events and plaque rupture data. This article reviews recent advances in coronary plaque research over the past decade, including medical imaging techniques represented by intravascular ultrasound (IVUS) and optical coherence tomography (OCT), computational modeling and their applications in plaque progression and vulnerability analyses and predictions. The… More >

Biyue Liu^1,*, Dalin Tang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 25-26, 2019, DOI:10.32604/mcb.2019.06825

Abstract The blood flow and mass transport pattern of low-density lipoprotein (LDL) in a right coronary artery with two stenoses are studied. Computations were carried out under physiological conditions. Our results show a strong correlation between wall shear stress (WSS) and distribution patterns of LDL. More >

Liang Wang¹, Haibo Jia², Luping He², Rui Lv¹, Xiaoya Guo³, Chun Yang^4,5, Don P. Giddens^6,7, Habib Samady⁶, Akiko Maehara⁸, Gary S. Mintz⁸, Dalin Tang^1,*,5

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 23-24, 2019, DOI:10.32604/mcb.2019.07522

Abstract Plaque erosion, one of the primary causes for coronary thrombosis, is responsible for about one third of the patients with acute coronary syndrome (ACS) [1]. Histological studies characterized the eroded plaque as a plaque with following morphological features: 1) plaque intima having direct contact with intraluminal thrombus due to the absence of endothelium or endothelial injury; 2) without rupture in the fibrous cap; 3) abundance of proteoglycans and smooth muscle cells on the luminal surface under the thrombus [2]. These characteristics has been applied in in vivo diagnosis of plaque erosion using optical coherence tomography… More >