Reham Reda^{1, *}

FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.3, pp. 171-185, 2019, DOI:10.32604/fdmp.2019.03923

Abstract Constrained groove pressing (CGP) is a severe plastic deformation (SPD) technique used as a strengthening method for sheet metal. In the current work, an optimal/cost-saving design for CGP dies was attained using the stress analysis tool in SolidWorks Simulation Xpress wizard. This study examined low-cost and widely industrially applied aluminium materials, i.e., pure 1050 Al and 5052 Al alloy. Each material was subjected to three passes of the CGP process using a 150 tons capacity press. For both materials, inter-pass annealing treatment was undertaken before the third pass. The effect of the number of CGP… More >

Manoochehr MESSRIPOUR¹, Azadeh MESRIPOUR²

BIOCELL, Vol.43, No.1, pp. 37-40, 2019, DOI:10.32604/biocell.2019.05865

Abstract DNA damage and the enzyme poly (ADP-ribose) polymerase (PARP) associated with the pathogenesis of numerous age-related neurodegenerative disorders. Astrocytes play crucial roles in both support metabolic functions and cell viability of the brain. PARP regulates DNA damage and repair in the brain cells. In this study PARP activity and DNA strand break were investigated in the astrocytes isolated from young and aged rat brain. Three and 30-month-old rats were killed by decapitation and brains were removed onto an ice cooled glass plate. Astrocytes were isolated by sucrose density gradient centrifugation and glutamine synthetase (GS) served… More >

Odin RAMÍREZ-FERNÁNDEZ^1,2,3,*, Ludovika CACOPARDO¹, Benjamín LEON-MANCILLA², Joana COSTA¹

BIOCELL, Vol.43, No.1, pp. 29-36, 2019, DOI:10.32604/biocell.2019.04790

Abstract We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy More >

Nesrine EBRAHIM¹, Eman EHSAN², Eman Abd EL GHANY², Dina SABRY³, Ashraf SHAMAA⁴

BIOCELL, Vol.43, No.1, pp. 21-28, 2019, DOI:10.32604/biocell.2019.06111

Abstract The neonatal hypoxic–ischemic encephalopathy (HIE) is an important cause of neurological morbidity and mortality in neonates. Cell therapy is considered a promising method for treating severe neurological disorders such as this one. Stem cells have the capacity for self-renewal and differentiation into certain cell lineages. The present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells (BMSCs) administration for the attenuation of experimentally induced HIE in neonatal rats. Sixty neonatal rats were divided randomly into four groups. Group 1: control group. Group 2: rats were exposed to… More >

Ana Laura CIMADOR^1,#, Emeli Luciana GALANTE^1,#, Lucila Ibel MUÑOZ^1,#, Patricia Silvia ROMANO^2,3, Antonella Denisse LOSINNO^1,2, María Cristina VANRELL^1,2,3

BIOCELL, Vol.43, No.1, pp. 13-20, 2019, DOI:10.32604/biocell.2019.07018

Abstract Trypanosoma rangeli and T. cruzi are both parasitic unicellular species that infect humans. Unlike T. cruzi, the causative agent of Chagas disease, T. rangeli is an infective and non-pathogenic parasite for humans, but pathogenic for vectors from the Rhodnius genus. Because both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of T. rangeli in mammalian cells, we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on it. We found that T. rangeli exhibits a cycle of… More >

Wen LI, Junli YANG, Dong ZHOU, Jinghui ZHANG, Qingcui ZHUO

BIOCELL, Vol.43, No.1, pp. 7-12, 2019, DOI:10.32604/biocell.2019.04763

Abstract The efficacy and safety of ganglioside in the treatment of neonates who suffer from hypoxic–ischemic encephalopathy (HIE) needs to be fully evaluated. We searched the following databases: PubMed, ScienceDirect, LISTA, CNKI, Chinese biomedical literature database and Wanfang digital journals of full-text database to determine the inclusion and exclusion criteria of papers and a total of 12 papers were included after quality evaluation. Then we conducted the meta-analysis with RevMan5.0 software. The results showed that compared with the control group, the abnormal rate declined in the ganglioside-treated group (relative risk (RR)=0.27, 95% confidence interval (CI)= 0.05– More >

Jesus Sebastian DISTEL¹, Walter BERON¹, Rodolfo Matias ORTIZ FLORES^1,2

BIOCELL, Vol.43, No.1, pp. 1-6, 2019, DOI:10.32604/biocell.2019.07021

Abstract Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever. In this brief review, we describe how recently described mechanisms help our understanding of C. burnetii invasion and its survival in the host cell by the formation of a replicative niche: the Coxiella-containing vacuole. We describe the actin-associated proteins involved in the internalization of C. burnetii, and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole. More >

Kazunori Shinohara^{1, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.3, pp. 599-647, 2019, DOI:10.31614/cmes.2019.04472

Abstract According to the wave power rule, the second derivative of a function x(t) with respect to the variable t is equal to negative n times the function x(t) raised to the power of 2n-1. Solving the ordinary differential equations numerically results in waves appearing in the figures. The ordinary differential equation is very simple; however, waves, including the regular amplitude and period, are drawn in the figure. In this study, the function for obtaining the wave is called the leaf function. Based on the leaf function, the exact solutions for the undamped and unforced Duffing equations… More >

Yanxin Wang^{1, *}, Li Zhu¹, Zhi Wang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 339-350, 2019, DOI:10.31614/cmes.2019.04575

Abstract An Euler wavelets method is proposed to solve a class of nonlinear variable order fractional differential equations in this paper. The properties of Euler wavelets and their operational matrix together with a family of piecewise functions are first presented. Then they are utilized to reduce the problem to the solution of a nonlinear system of algebraic equations. And the convergence of the Euler wavelets basis is given. The method is computationally attractive and some numerical examples are provided to illustrate its high accuracy. More >

Lei Peng^1,2, Zhiqiang Feng^1,2,*, Pierre Joli², Christine Renaud²

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.1, pp. 111-137, 2019, DOI:10.31614/cmes.2018.04556

Abstract In order to investigate the mechanical behavior of systems with complex architecture and a large number of contacting bodies, a finite element software, named LiToTac, has been developed by using the object-oriented programming technique. This software, with an interactive graphical user interface, is able to handle highly non-linear problems including multiple contacts and large deformation. More importantly, the contact detection based on a hybrid three-stages methodology can be performed automatically, which is more efficient than the common strategies of pre-defining contact zones in commercial FEM software like ANSYS, ABAQUS, etc. In addition, the contact solver More >